15(R)-15-Methyl prostaglandin D2 is a metabolically stable synthetic analog of PGD2 that selectively targets the CRTH2/DP2 receptor. This compound is known for its potent biological activities, including the regulation of eosinophil functions such as CD11b expression, actin polymerization, and chemotaxis, with EC50 values of 1.4, 3.8, and 1.7 nM, respectively. Its efficacy in these activities is significantly greater compared to natural PGD2. Additionally, 15(R)-15-Methyl prostaglandin D2 shows minimal action on the DP1 receptor, making it a valuable tool for research in immunology and inflammation studies.
15(R)-15-Methyl prostaglandin D2 is a metabolically stable synthetic analog of PGD2 that selectively targets the CRTH2/DP2 receptor. This compound is known for its potent biological activities, including the regulation of eosinophil functions such as CD11b expression, actin polymerization, and chemotaxis, with EC50 values of 1.4, 3.8, and 1.7 nM, respectively. Its efficacy in these activities is significantly greater compared to natural PGD2. Additionally, 15(R)-15-Methyl prostaglandin D2 shows minimal action on the DP1 receptor, making it a valuable tool for research in immunology and inflammation studies.
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