Fig. 1 · Structure
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15(R)-15-Methyl prostaglandin D2
PGD2 Analog
15(R)-15-Methyl prostaglandin D2 is a metabolically stable synthetic analog of PGD2 that selectively targets the CRTH2/DP2 receptor. This compound is known for its potent biological activities, including the regulation of eosinophil functions such as CD11b expression, actin polymerization, and chemotaxis, with EC50 values of 1.4, 3.8, and 1.7 nM, respectively. Its efficacy in these activities is significantly greater compared to natural PGD2. Additionally, 15(R)-15-Methyl prostaglandin D2 shows minimal action on the DP1 receptor, making it a valuable tool for research in immunology and inflammation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 210978-26-0 |
| Applications | PGD2 Analog |
| Formula | C21H34O5 |
| Molecular Weight | 366.49 |
| Synonyms | 15(R)-15-Methyl PGD2 |
| SMILES | CCCCC[C@@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\CCCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.