Catalog No.
Product Name
Application
Product Information
Citations
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TxA2 Synthase/Receptor Inhibitor
Picotamide monohydrate is a dual inhibitor of thromboxane A2 (TxA2) synthase and its receptor, exhibiting significant antiplatelet activity. This compound has been shown to reduce microalbuminuria and inhibit the progression of carotid plaques in diabetic models. Picotamide monohydrate serves as a valuable tool for investigating both acute and chronic cardiovascular diseases in research settings. -
TBXA2R Antagonist
Domitroban is a thromboxane A2 receptor (TBXA2R) antagonist that effectively inhibits platelet aggregation. This compound is valuable for research focused on cardiovascular diseases, particularly in the context of thrombosis. Its antagonistic action on TBXA2R makes it an essential tool for studying platelet-related disorders and developing therapeutics for cardiovascular conditions. -
Prostaglandin E2 Inhibitor
Seprilose is a potent inhibitor of prostaglandin E2 synthesis, acting primarily by targeting the relevant enzymatic pathways involved in its production. This compound demonstrates significant anti-inflammatory activity, making it valuable for research applications focused on inflammation and related disorders. Seprilose can be utilized in studies examining the role of prostaglandins in various physiological and pathological processes. -
Prostaglandin E1 Metabolite
Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1, acting as a ligand for prostanoid receptors. It plays a significant role in various biological processes, including mediating inflammation and regulating vascular functions. PGB1 is widely used in research to explore its physiological effects and potential therapeutic applications in cardiovascular and inflammatory diseases. -
Thromboxane Synthase Inhibitor
Imitrodast is a selective thromboxane synthase inhibitor, effectively blocking the conversion of arachidonic acid to thromboxane A2. This compound demonstrates significant activity in modulating bronchoconstriction and possesses potential applications in research related to respiratory disorders and cardiovascular diseases. Its mechanism may help elucidate the role of thromboxane in various pathological conditions. -
TXA2 Receptor Antagonist
KT2-962 is a thromboxane A2 (TXA2) receptor antagonist and a potent hydroxyl radical scavenger (IC50=500 nM). This compound has been shown to significantly reduce myocardial infarct size and the incidence of ventricular fibrillation. In a canine model of ischemia/reperfusion, KT2-962 demonstrated notable cardioprotective effects, making it valuable for research into myocardial ischemia-reperfusion injury and TXA2-mediated vascular diseases. -
PTGER2 Agonist
15(S)-Fluprostenol is a potent agonist of the PTGER2 receptor. It has been shown to decrease the expression of Oviductal glycoprotein 1 (OVGP1), indicating its potential role in regulating reproductive processes. This compound is useful in research applications related to prostaglandin signaling pathways and reproductive biology studies. -
Prostaglandin Analog
(15R)-Bimatoprost is a prostaglandin analog that primarily targets the prostaglandin receptor pathways. This compound is utilized in the research of glaucoma and ocular hypertension, providing valuable insights into their mechanisms and treatment options. As an isomer of Bimatoprost, (15R)-Bimatoprost features an inverted (β) hydroxyl group at C-15, which may contribute to its unique biological activities. -
Antiulcer Compound
Spizofurone is an anti-ulcer compound that enhances gastric mucosal blood flow, demonstrating significant oral bioactivity. It shares a mechanism of action similar to PGE2, functioning through both local and systemic pathways to promote ulcer healing by improving blood supply to the gastric mucosa. This compound is valuable for research into the strategies for treating and managing gastric ulcers. -
Thromboxane Synthase Inhibitor
Rolafagrel is a selective inhibitor of thromboxane synthase, a key enzyme involved in the synthesis of thromboxane A2, which plays a pivotal role in platelet aggregation and vascular contraction. This compound has significant implications in cardiovascular research, facilitating the study of thromboxane-mediated pathways and their contribution to various cardiovascular disorders. Its use may aid in the development of therapeutic strategies targeting thromboxane-related conditions. -
EP3 Antagonist
EP3 Antagonist 4 is a selective antagonist of the EP3 receptor, exhibiting a Ki value of 2 nM for human EP3. It demonstrates low in vivo clearance and high oral bioavailability, as evidenced by pharmacokinetic studies in rats. This compound is primarily utilized in the research of beta cell dysfunction in diabetes, contributing to our understanding of metabolic disorders and potential therapeutic interventions. -
Endogenous Hormone
Prostaglandin F2α alcohol methyl ether is a G protein-coupled receptor that acts as an analog of the endogenous hormone prostaglandin F2α. This compound exhibits significant biological activity in pain modulation, potentially serving as a nociceptive mediator in the spinal cord. It is applicable in research exploring reproductive biology, particularly in the context of luteinizing hormone function and associated signaling pathways. -
Antihypertensive Agent
15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester is a PGE2 analogue exhibiting antihypertensive properties. This compound functions primarily by modulating vascular tone and promoting vasodilation, making it a valuable tool in cardiovascular disease research. Its utility in studying mechanisms of hypertension and potential therapeutic effects on related disorders further underscores its significance in the field of cardiovascular pharmacology. -
Prostaglandin Receptor Control
15-OH Tafluprost is a synthetic analog of prostaglandin F2α (PGF2α) that targets prostaglandin receptors to modulate vascular responses. It effectively alleviates endothelin-1 (ET-1)-induced impairments in optic nerve head (ONH) blood flow and counteracts contraction of isolated ciliary artery segments. This compound is pertinent for investigating mechanisms of intraocular pressure regulation and potential therapeutic approaches for glaucoma-related vascular dysfunction. -
DP2 Receptor Inhibitor
CRTh2 antagonist 4 is a selective inhibitor of the DP2 receptor, displaying an IC50 value of 212 nM and a binding affinity with a Ki of 37 nM. This compound is useful in the investigation of TH2 lymphocyte-related pathways and has potential applications in understanding and treating severe allergic diseases. -
Prostaglandin Receptor Agonist
Δ17-6-keto Prostaglandin F1α is a prostaglandin receptor agonist derived from the cyclooxygenase pathway of eicosapentaenoic acid (EPA). This compound is known to exhibit key biological activity, potentially influencing inflammatory responses and vascular dynamics. Research suggests that Δ17-6-keto PGF1α, along with other 3-series COX products from EPA, may play a role in mitigating the risk of glaucoma, particularly in populations with diets rich in marine sources of EPA. -
EP4 Receptor Agonist
EP4 Receptor Agonist 1 is a selective agonist for the EP4 receptor, demonstrating a human pEC50 value of 6.3. This compound is pivotal for studying the physiological roles of EP4 in various biological processes. Research applications include exploring mechanisms related to inflammation, pain modulation, and potential therapeutic avenues for diseases where EP4 signaling is implicated. -
Thromboxane Synthase Inhibitor
Imitrodast sodium is a potent thromboxane synthase inhibitor. This compound plays a significant role in research related to bronchoconstriction and its associated pathways. Its ability to inhibit thromboxane production offers insights into the mechanisms of allergic reactions and pulmonary function, making it valuable for studies focused on respiratory health and related conditions. -
Pain Reliever
Nocistatin (human) is a peptide that acts as a potent pain reliever by blocking nociceptin-induced allodynia and hyperalgesia. Its ability to attenuate pain evoked by prostaglandin E2 positions Nocistatin as a valuable reagent for research in pain management and nociceptive signaling pathways. This compound is relevant for studies aimed at understanding pain mechanisms and developing therapeutic strategies for pain relief. -
Vasoconstrictor
ent-8-iso Prostaglandin F2α is a potent vasoconstrictor primarily targeting porcine retinal and cerebral microvessels. It exhibits EC50 values of 30.6 nM and 53.5 nM, respectively, demonstrating its effectiveness in modulating vascular tone. This compound is useful for research applications involving vascular biology, neurovascular function, and studies of ocular physiology. -
EP2 Antagonist
TG11-77 hydrochloride is a highly selective antagonist of the EP2 receptor, demonstrating potent inhibition with a KB value of 9.7 nM. This compound effectively blocks PGE2-induced activation of the human EP2 receptor, leading to significant anti-inflammatory effects. TG11-77 hydrochloride has also been shown to reduce delayed mortality and mitigate memory deficits, making it a valuable tool for research in neuroinflammation and related therapeutic areas. -
Prostaglandin Lactone
PGF2α 1,9-lactone is a stable prostaglandin lactone that demonstrates resistance to hydrolysis by plasma esterases. This compound is critical in studies examining the pharmacological effects of prostaglandins and their roles in various biological processes. PGF2α 1,9-lactone is utilized in research focused on reproductive biology, cardiovascular function, and inflammation, providing valuable insights into prostaglandin signaling pathways. -
FP Receptor Agonist
Cloprostenol isopropyl ester is a potent FP receptor agonist, exhibiting a dissociation constant (Ki) of 28 nM. This compound serves as a prostaglandin F2α analog and is a valuable intermediate for synthesizing (+)-Cloprostenol. Its biological activity makes it suitable for research applications in reproductive biology and studies involving prostaglandin signaling pathways. -
Metabolite
Dinorprostaglandin E1 (dinor-PGE1) is a key metabolite of prostaglandin E1 and prostaglandin E. It primarily exerts its biological activity by inhibiting glycogenolysis stimulated by glucagon, epinephrine, and isoproterenol, particularly in hepatocytes. This compound is important for research applications focused on metabolic regulation and the signaling pathways influenced by prostaglandins. -
TXA2/PGH2 Receptor Antagonist
ONO 3708 is a selective antagonist of the TXA2/PGH2 receptor, effectively inhibiting the binding of U46619 to human platelets with an IC50 value of 38 nM. This compound is valuable for research into platelet activation and thrombus formation, making it applicable in studies focused on cardiovascular diseases and coagulation processes. Its specificity allows for detailed investigation of TXA2 signaling pathways and their implications in various physiological and pathological conditions. -
Thromboxane B2 Metabolite
2,3-Dinor thromboxane B1 is a key urinary metabolite of Thromboxane B2, functioning as a biomarker in thromboxane biosynthesis pathways. This compound is important for studying platelet activation and vascular physiology, as it is involved in various cardiovascular and inflammatory responses. Research applications include the investigation of thromboxane signaling and its implications in thromboembolic disorders. -
Prostaglandin Derivative
15(R)-Prostaglandin E2 is a prostaglandin derivative that modulates various physiological processes through its interaction with prostaglandin receptors. It exhibits significant biological activity including anti-inflammatory effects and the regulation of blood flow. This compound is utilized in research focused on inflammation, vascular biology, and the mechanisms underlying pain and fever responses. -
TXA2 Receptor Inhibitor
BM-531 is a dual-action thromboxane receptor (TXA2) inhibitor that also functions as a thromboxane synthase inhibitor. This compound demonstrates significant anti-aggregatory effects on human citrated platelet-rich plasma, effectively inhibiting arachidonic acid-induced aggregation with an ED100 of 0.125 μM and U-46619-induced aggregation with an ED50 of 0.482 μM. Additionally, BM-531 is shown to inhibit contraction in porcine uterine smooth muscle induced by high potassium levels, making it a valuable tool for research in thrombosis and uterine contractility studies. -
Prostaglandin Analog
Latanoprost ethyl amide is a modified prostaglandin analog that serves as a selective ocular hypotensive agent. By altering the C-1 carboxyl group to an N-ethyl amide, this compound may offer an alternative delivery mechanism for prostaglandin activity. Recent studies reveal that Latanoprost ethyl amide can be converted to its active free acid form in bovine and human corneal tissue, albeit at a slower rate compared to traditional prostaglandin esters. This unique pharmacokinetic profile may enhance its therapeutic potential in the treatment of intraocular pressure-related conditions. -
EP4 Antagonist
TP-16 is a selective antagonist of the EP4 receptor, demonstrating an IC50 value of 2.1 nM. This compound effectively inhibits EP4-mediated signaling pathways, making it a valuable tool for investigating the role of EP4 in various physiological and pathological processes. TP-16 is particularly relevant for research in inflammation, pain, and cancer biology, providing insights into therapeutic interventions targeting the prostaglandin receptor system. -
Prostacyclin Analog
OP-2507 is a prostacyclin analog that primarily targets prostacyclin receptors. It has been shown to elevate glucose levels in the brain of mice and mitigate energy metabolism disruptions under hypoxic conditions. Additionally, OP-2507 exerts protective effects on cyclic nucleotide levels in hypoxic brain tissue, specifically enhancing cyclic AMP while reducing cyclic GMP. This compound demonstrates potential in addressing brain hypoxia and associated edema. -
Cyclooxygenase Inhibitor
KC-764 is an orally active, reversible inhibitor of cyclooxygenase, preferentially targeting platelet cyclooxygenase. It effectively reduces platelet thromboxane A2 (TXA2) production and inhibits platelet aggregation, exhibiting IC50 values of 0.23 μM and 26 nM, respectively. This compound is valuable for research focused on antiplatelet therapy and the prevention of recurrence in ischemic stroke. -
TXA2 Inhibitor
(E/Z)-Ozagrel sodium is a selective thromboxane A2 (TXA2) synthase inhibitor, exhibiting an IC50 value of 11 nM. By inhibiting TXA2 production, it promotes vasodilation and exhibits anti-platelet aggregation and anti-inflammatory effects through increased prostacyclin (PGI2) levels. This reagent is valuable for research into ischemic stroke, asthma, and thromboembolic diseases. -
FP/TP Receptor Inhibitor
CAY10535 is an inhibitor of the FP and TP receptors, targeting key pathways involved in cardiovascular function. This compound demonstrates potential for elucidating the role of these receptors in cardiovascular disease pathology. It serves as a valuable tool for researchers investigating therapeutic interventions aimed at modulating prostanoid signaling in cardiovascular conditions. -
Carbacyclin Derivative
Carbaprostacyclin methyl ester is a methylated derivative of Carbacyclin, primarily targeting prostacyclin receptors. This compound exhibits potent vasodilatory effects and anti-platelet aggregation properties. It is utilized in cardiovascular research to investigate the modulation of blood flow and platelet function, making it essential for studies related to thrombotic disorders and vascular health. -
Prostaglandin Receptor
9-deoxy-9-methylene Prostaglandin E2 is a stable isosteric analog of Prostaglandin E2 (PGE2) targeting prostaglandin receptors. It exhibits similar biological activity to PGE2 while demonstrating a reduced side effect profile. Research indicates that 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in lowering blood pressure in rats and effectively stimulates colonic activity in gerbils as well as uterine contractions in primates, making it valuable for studies on cardiovascular and reproductive physiology. -
FP Antagonist
Prostaglandin F2α dimethyl amine is a derivative of Prostaglandin F2α that serves as an antagonist for the Prostaglandin F receptor (FP). This compound effectively inhibits the cardiovascular responses triggered by orexin and arachidonic acid, making it a valuable tool in cardiovascular research. Its ability to modulate FP activity positions it as a significant reagent for studies investigating prostaglandin-mediated signaling pathways and related physiological effects. -
PGD2 Metabolite
Tetranor-PGDM is a key urinary metabolite derived from prostaglandin D2 (PGD2) biosynthesis. It serves as an essential biomarker for studying PGD2 metabolism and its associated biological pathways. This compound is widely utilized in research applications aimed at understanding inflammatory responses, sleep regulation, and allergic reactions linked to PGD2 levels. -
Prostaglandin Receptor Inhibitor
Iso-Samixogrel is a potent prostaglandin receptor inhibitor, functioning as both a thromboxane A2 receptor blocker and a thromboxane synthetase inhibitor. This compound demonstrates significant antithrombotic activity by effectively preventing recurrent arterial thrombus formation and inhibiting collagen-induced platelet aggregation in ex vivo studies. Additionally, Iso-Samixogrel prolongs sublingual bleeding time, indicating its potential utility in the management of thrombotic disorders. -
Prostacyclin Receptor Agonist
AFP-07 free acid is a potent and selective agonist of the prostacyclin IP receptor, exhibiting a Ki value of 0.561 nM. This compound is used in research applications related to cardiovascular biology and inflammation, where it may help elucidate the role of prostacyclin signaling in various pathophysiological processes. Its specificity makes AFP-07 free acid a valuable tool for studying the therapeutic potential of prostacyclin modulation in disease models. -
PGF2 Analog
20-ethyl Prostaglandin F2α is a synthetic analog of Prostaglandin F2α, functioning as a potent modulator of the prostaglandin pathway. It exhibits key biological activities, including contraction of smooth muscle and regulation of vascular tone. This compound is widely used in research applications related to reproductive biology, cardiovascular studies, and inflammation. -
EP3 Receptor Agonist
MB-28767 is an EP3 receptor agonist that specifically activates the prostaglandin E receptor subtype 3. This compound exhibits significant biological activity in modulating inflammatory responses and has potential applications in pain management and neuroprotection research. Its ability to influence various physiological processes makes it a valuable tool in studying EP3 receptor-related pathways in diverse biological systems. -
Prostaglandin Receptor
15(S)-15-methyl Prostaglandin D2 is a synthetic analog of PGD2 that targets prostaglandin receptors, offering enhanced metabolic stability. This compound is known to induce vasoconstriction and elevate systemic blood pressure while exhibiting significantly reduced inhibitory effects on ADP-induced platelet aggregation. Additionally, it demonstrates potent antifertility activity in hamsters, being 200-fold more effective than PGD2. It serves as a valuable tool for research into cardiovascular physiology and reproductive biology. -
Dinoprost Analog
PGF2α analogue-1 is a dinoprost analog featuring an acetylenic fluorobenzene substituent within the lower side chain. This compound is designed to selectively interact with prostaglandin receptors, exhibiting significant biological activity related to smooth muscle contraction and modulation of vascular tone. It serves as a valuable tool in research applications focused on reproductive biology, cardiovascular studies, and the exploration of inflammation pathways. -
TXA2 Inhibitor
Isbogrel is a selective inhibitor of thromboxane A2 (TXA2) synthase, demonstrating potent activity in reducing TXA2 generation in the bloodstream. With an ID50 value of 0.04 mg/kg, Isbogrel exhibits effective oral bioavailability. This compound is primarily utilized in research focused on cardiovascular diseases and thrombotic disorders, contributing to the understanding of TXA2's role in platelet aggregation and vascular functions. -
Antiprogestogen Drug
Gemeprost is an analogue of Prostaglandin E1 that functions as a potent antiprogestogen. This compound is primarily used in research related to second trimester abortion, influencing reproductive tissue by modulating progesterone activity. Its biological activity makes it a valuable tool for studies investigating reproductive health and associated therapies. -
PGI2 Agonist
FR181157 is an orally active prostacyclin (PGI2) agonist that exhibits favorable pharmacokinetic properties. It plays a crucial role in promoting vasodilation and inhibiting platelet aggregation, making it valuable for research in cardiovascular disorders and pulmonary hypertension. Its potent biological activity provides a useful tool for understanding the therapeutic potential of PGI2 modulation in various disease models. -
Derivative of PGA2
Prostaglandin A2 methyl ester is a methylated derivative of prostaglandin A2, known for its role in various physiological processes. This compound is used in research to study the effects of prostaglandins in inflammation, pain modulation, and reproductive functions. Its ability to mimic the biological activity of PGA2 makes it a valuable tool for exploring signaling pathways and potential therapeutic targets in related studies. -
C-8 Diastereomer of BW 245C
(8-epi)-BW 245C is the C-8 diastereomer of BW 245C, functioning as a selective agonist for the PGD2 receptor. This compound exhibits high affinity for its target, making it a valuable tool in studying PGD2-mediated signaling pathways. Its utility extends to research in areas such as inflammation, allergy responses, and sleep regulation, providing insights into the role of PGD2 in various biological processes. -
EP2 Receptor Antagonist
TG6-129 is a selective antagonist of the EP2 receptor, primarily involved in modulating inflammatory responses. This compound has been shown to reduce the expression of inflammatory factors induced by butaprost in P388D1 macrophages. TG6-129 is valuable for researchers studying inflammation and related signaling pathways.
