Fig. 1 · Structure
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EP3 antagonist 4
EP3 Antagonist
EP3 Antagonist 4 is a selective antagonist of the EP3 receptor, exhibiting a Ki value of 2 nM for human EP3. It demonstrates low in vivo clearance and high oral bioavailability, as evidenced by pharmacokinetic studies in rats. This compound is primarily utilized in the research of beta cell dysfunction in diabetes, contributing to our understanding of metabolic disorders and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2408297-80-1 |
| Applications | EP3 Antagonist |
| Formula | C22H20Cl3FN4O3S2 |
| Molecular Weight | 577.91 |
| SMILES | O=S(NC(NC/C(F)=C1CCCC(C=N2)=C\1N2CC3=C(C=C(C=C3)Cl)Cl)=O)(C4=CC(C)=C(S4)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.