ONO 3708

Catalog No.: A63230
TXA2/PGH2 Receptor Antagonist
ONO 3708 is a selective antagonist of the TXA2/PGH2 receptor, effectively inhibiting the binding of U46619 to human platelets with an IC50 value of 38 nM. This compound is valuable for research into platelet activation and thrombus formation, making it applicable in studies focused on cardiovascular diseases and coagulation processes. Its specificity allows for detailed investigation of TXA2 signaling pathways and their implications in various physiological and pathological conditions.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionONO 3708 is a selective antagonist of the TXA2/PGH2 receptor, effectively inhibiting the binding of U46619 to human platelets with an IC50 value of 38 nM. This compound is valuable for research into platelet activation and thrombus formation, making it applicable in studies focused on cardiovascular diseases and coagulation processes. Its specificity allows for detailed investigation of TXA2 signaling pathways and their implications in various physiological and pathological conditions.
Product Information
Catalog NumA63230
FormulaC23H37NO4
Molecular Weight391.54
CAS Number102191-05-9
SMILESOC(CCC/C=C\C[C@H]1[C@H](C2)C(C)([C@H]2C[C@@H]1NC([C@@H](C3CCCC3)O)=O)C)=O
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