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Nocistatin(human)

Catalog No.: A63223
Pain Reliever
Nocistatin (human) is a peptide that acts as a potent pain reliever by blocking nociceptin-induced allodynia and hyperalgesia. Its ability to attenuate pain evoked by prostaglandin E2 positions Nocistatin as a valuable reagent for research in pain management and nociceptive signaling pathways. This compound is relevant for studies aimed at understanding pain mechanisms and developing therapeutic strategies for pain relief.
Nocistatin(human) 212609-11-5 Pain Reliever
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Size Price Stock Qty
1mg
$345.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNocistatin (human) is a peptide that acts as a potent pain reliever by blocking nociceptin-induced allodynia and hyperalgesia. Its ability to attenuate pain evoked by prostaglandin E2 positions Nocistatin as a valuable reagent for research in pain management and nociceptive signaling pathways. This compound is relevant for studies aimed at understanding pain mechanisms and developing therapeutic strategies for pain relief.
Product Information
Catalog NumA63223
FormulaC149H238N42O53S3
Molecular Weight3561.93
CAS Number212609-11-5
SequenceMet-Pro-Arg-Val-Arg-Ser-Leu-Phe-Gln-Glu-Gln-Glu-Glu-Pro-Glu-Pro-Gly-Met-Glu-Glu-Ala-Gly-Glu-Met-Glu-Gln-Lys-Gln-Leu-Gln
Sequence shorteningMPRVRSLFQEQEEPEPGMEEAGEMEQKQLQ
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CCSC)N)=O)CCC2)CCCNC(=N)N)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)CO)=O)CC(C)C)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)(=O)N3[C@H](C(N[C@H](C(=O)N4[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCCN)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCSC)=O)CCC(O)=O)=O)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCSC)=O)=O)CCC4)CCC(O)=O)=O)CCC3
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GPCR/G Protein > Prostanoid Receptors