Catalog No.
Product Name
Application
Product Information
Citations
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EP4 Receptor Antagonist
BGC-20-1531 hydrochloride is a potent and selective antagonist of the prostanoid EP4 receptor, exhibiting a pKb of 7.6. This compound is primarily utilized in research related to migraine headaches, where modulation of the EP4 receptor may influence pain pathways and inflammatory processes. Its specificity makes it a valuable tool for investigating the roles of prostanoid signaling in various biological contexts. -
TP Agonist
AGN192093 is a selective thromboxane A2 receptor (TP) agonist, demonstrating an EC50 of 1.3 nM. This compound exhibits potent activity in modulating vascular responses and is useful for studies related to cardiovascular physiology and pathology. AGN192093 serves as a valuable tool for investigating the role of thromboxane A2 in various biological processes and disease models. -
Prostaglandin Receptor Antagonist
AL-3138 (11-Deoxy-16-fluoro PGF2α) functions as a prostaglandin receptor antagonist, specifically targeting the FP receptor. It effectively inhibits inositol phosphate production mediated by the FP prostaglandin receptor. This compound is valuable for research applications focused on prostaglandin signaling pathways and their implications in various physiological and pathological processes. -
Latanoprost Derivative
Latanoprost amide is a derivative of the F-prostaglandin (FP) receptor agonist, Latanoprost. It primarily acts on the FP receptor, demonstrating significant activity in reducing intraocular pressure. This compound is valuable in pharmacological research related to glaucoma and ocular hypertension, aiding in the development of new therapies targeting similar mechanisms. -
Prostaglandin Receptor
16-Phenoxy tetranor prostaglandin F2α is a metabolically stable analog that selectively binds to the FP receptor. This compound demonstrates significantly enhanced affinity for the FP receptor on ovine luteal cells, exhibiting a 440% increase compared to PGF2α. Its robust interaction profile makes it a valuable tool for investigating prostaglandin signaling pathways and their role in reproductive biology and endocrine functions. -
Thromboxane Inhibitor
BM567 is a potent thromboxane A2 receptor (TXR) antagonist and thromboxane A2 synthase (TXS) inhibitor, with IC50 values of 1.1 nM and 12 nM, respectively. This sulfonylurea compound demonstrates significant antithrombogenic activity, making it a valuable tool for studying thromboxane signaling pathways in various biological contexts. Its application extends to research on cardiovascular diseases and the role of thromboxane in platelet aggregation and vasoconstriction. -
PGI2 Agonist
FR-181877 is a selective PGI2 agonist that enhances prostacyclin signaling. It exhibits significant inhibitory activity on ADP-induced human platelet aggregation, with an IC50 value of 0.081 μM. This compound is valuable for research focusing on cardiovascular biology and hemostasis, offering insights into platelet function and potential therapeutic applications in thrombotic disorders. -
Prostaglandin Derivative
13(R),14(R)-epoxy Fluprostenol isopropyl ester is a Prostaglandin derivative that exhibits potent activity by acting on the FP receptors. This compound is primarily used in research to study its role in reproductive biology and vascular function. Its unique chemical structure allows for exploration in various pharmacological applications, particularly in the development of therapeutics targeting prostaglandin pathways. -
Thromboxane A2 Receptor Inhibitor
Samixogrel is a potent thromboxane A2 receptor inhibitor that modulates thromboxane synthesis. Its mechanism of action involves blocking the thromboxane A2 signaling pathway, which is crucial for platelet aggregation and vascular constriction. This compound is primarily utilized in research related to cardiovascular disease and thrombotic disorders, providing valuable insights into the role of thromboxane A2 in pathophysiological processes. -
Crth2 Antagonist
CRTh2 antagonist 3 is a potent antagonist of the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTh2). This compound enhances the activity of phosphoinositide-dependent kinase-1 (PDK1) towards a short peptide substrate, exhibiting an EC50 of 2 μM and a Kd of 8.4 μM. Its potential applications include research into cardiovascular inflammation and the modulation of Th2-mediated responses. -
Cervical Dilator
Meteneprost potassium is a cervical dilator that primarily acts by stimulating uterine contractions and facilitating the dilation of the cervical canal. This agent is utilized in obstetric applications, particularly for the induction of labor and cervical preparation prior to surgical procedures. Its efficacy in promoting cervical ripening makes it a valuable reagent in reproductive health research. -
EP2 Receptor Agonist
EP2 receptor agonist 2 (compound 18a) is a highly selective G protein-biased agonist of the EP2 receptor, demonstrating an EC50 of 13 nM for hEP2G protein activation and minimal interaction with the β-arrestin pathway (EC50 > 10000 nM). This compound exhibits remarkable selectivity for the EP2 receptor, with EC50 values greater than 10000 nM for hEP1, hEP3, hEP4, hIP, and hFP. It serves as a valuable tool for research in inflammation and pain pathways, facilitating studies on EP2 receptor signaling and its therapeutic potential. -
IP receptor Agonist
IP receptor agonist 1 is an orally active agonist of the I prostanoid receptor, exhibiting a potent IC50 of 0.15 μM for the inhibition of ADP-induced platelet aggregation in rabbit platelet-rich plasma. This compound is relevant for research applications focused on pulmonary arterial hypertension, offering insights into the modulation of platelet function and vascular health. -
PGF2α Analogue
Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α that functions primarily as a potent intraocular pressure (IOP) lowering agent. The N-ethyl amide modification enhances its efficacy compared to the parent compound, making it useful in research related to ocular health and glaucoma treatment. This compound is valuable for studies focused on the pharmacological modulation of IOP and the underlying mechanisms of action related to prostaglandin receptors. -
TP Agonist
8-iso-15-keto Prostaglandin F2α is a partial agonist targeting the Thromboxane receptor (TP). It demonstrates notable vasoconstrictive activity with a pD2 value of 5.8. Additionally, at elevated concentrations, this compound can induce mild relaxation effects in rat aorta rings, making it relevant for studies in vascular biology and related research applications. -
Prostacyclin Analogue
Nileprost is a prostacyclin analogue that functions as a mixed-type agonist for both PGI2 and PGE2 receptors. It demonstrates significant biological activity in promoting vasodilation and inhibiting platelet aggregation. Nileprost is primarily utilized in research involving acute myocardial ischemia, providing valuable insights into cardiovascular function and pathophysiology. -
DP/EP partial agonist
AL-6598 is a partial agonist of the prostaglandin DP and EP receptors. This compound is known to effectively reduce intraocular pressure, making it valuable for research related to glaucoma and ocular health. Investigations utilizing AL-6598 can provide insights into the mechanisms of intraocular pressure regulation and potential therapeutic strategies for glaucoma management. -
EP2/EP3 Receptors Agonist
11-Deoxy-16,16-dimethyl-PGE2 is an analog of Prostaglandin E2 that functions as an agonist of the EP2 and EP3 receptors. This compound exhibits protective effects against nephrotoxicity-induced damage in proximal renal tubular epithelial cells, primarily through its antioxidative properties. Its research applications include studies on renal protection, oxidative stress response, and receptor signaling pathways associated with kidney function. -
PGF2α Antagonist
Prostaglandin F2α dimethyl amide is an antagonist of Prostaglandin F2α, effectively inhibiting its biological activity. At a concentration of 3.2 μg/mL, it blocks up to 50% of PGF2α-induced contractions in the colon of gerbils (Meriones unguiculatus). This compound is valuable for research applications focused on gastrointestinal motility and prostaglandin signaling pathways. -
EP1 Receptor Antagonist
GW 848687X is a selective antagonist of the prostaglandin EP1 receptor, primarily involved in the modulation of inflammatory pain. This orally active compound demonstrates significant bioavailability, achieving 54% in rats and 53% in dogs. With a half-life of 2 hours, GW 848687X exhibits potential in both acute and chronic pain management research applications. -
Prostaglandin 2 Isosteric Analogue
11-Deoxy-11-methylene PGD2 is a chemically stable isosteric analogue of Prostaglandin D2, featuring an exocyclic methylene group in place of the 11-keto group. This compound has been shown to significantly stimulate fat storage, even in the presence of Indomethacin, highlighting its potential role in lipid metabolism research. It is a valuable tool for investigating the effects of prostaglandin analogues on adipogenesis and other metabolic processes. -
Prostaglandin Receptor Control
15(R)-15-Methyl prostaglandin F2α methyl ester is a 15-methyl substituted prostaglandin analog that acts primarily on prostaglandin receptors. This compound exhibits potential biological activities, including modulation of smooth muscle contraction and vascular responses. Its applications extend to reproductive biology, where it may assist in understanding mechanisms of labor induction and regulation of uterine dynamics. -
TXA2/Prostaglandin Receptor Antagonist
L-670596 is a selective thromboxane A2 receptor and prostaglandin receptor antagonist. This compound effectively inhibits bronchoconstriction induced by arachidonic acid and U-44069 in guinea pig models. Additionally, L-670596 reduces platelet aggregation triggered by U-44069 in human platelet-rich plasma, making it a valuable reagent for studies in cardiovascular and respiratory physiology. -
EP4 Receptor Antagonist
ER-819762 is a selective antagonist of the prostaglandin E2 (PGE2) EP4 receptor, demonstrating an EC50 value of 70 nM in human EP4 receptor assays. This compound is primarily employed in research related to rheumatoid arthritis, making it a valuable tool for investigating the role of EP4 signaling in inflammatory processes and potential therapeutic interventions. -
EP2 Receptor Agonist
ONO-8815Ly is a selective agonist of the EP2 receptor. It demonstrates the ability to inhibit spontaneous uterine contractility, making it a valuable tool for investigating mechanisms related to uterine dynamics. This compound is useful in research applications focused on reproductive biology and potential therapeutic avenues for uterine disorders. -
Prostaglandin Receptor Inhibitor
15(S)-Latanoprost is a potent agonist of prostaglandin receptors, exhibiting reduced activity compared to its parent compound, latanoprost. In a binding assay utilizing cat iris sphincter muscle, 15(S)-latanoprost demonstrated an IC50 value of 24 nM. Furthermore, administration of 3 μg of 15(S)-latanoprost resulted in a measurable decrease in intraocular pressure (IOP) by 1 mmHg in normotensive cynomolgus monkeys. This compound is valuable for research into ocular conditions and the modulation of intraocular pressure. -
Thromboxane Synthetase Inhibitor
Dazmegrel is a thromboxane synthetase inhibitor that effectively reduces the synthesis of Thromboxane A2 (TXA2), demonstrating antiplatelet and vasodilator properties. This compound is valuable in research focused on thrombosis and the modulation of platelet aggregation, making it a useful tool for studying cardiovascular diseases and related therapeutic interventions. -
EP1 Antagonist
GSK-269984B is a potent antagonist of the EP1 receptor, a key target in modulating prostaglandin signaling pathways. This compound exhibits significant anti-inflammatory properties and is primarily utilized in research related to inflammatory pain mechanisms. Its ability to inhibit EP1 receptor activity makes it a valuable tool for exploring therapeutic strategies in pain management and related conditions. -
PGI2 Analog
6α-Prostaglandin I1 is an analogue of prostacyclin I2 (PGI2) that exhibits enhanced stability in aqueous environments due to its resistance to hydrolysis. This compound primarily targets the prostacyclin receptor, playing a crucial role in mediating anti-inflammatory and vasodilatory effects. It is utilized in research applications focusing on cardiovascular health, vascular biology, and the investigation of prostaglandin pathways. -
TXA₂ Modulator
BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator that functions through specific inhibition of thromboxane synthase (TxAS) and antagonism of thromboxane receptors (TP). With an IC50 of 1.3 nM, it effectively inhibits platelet aggregation induced by arachidonic acid or TXA₂ analogues without affecting cyclooxygenase enzymes (COX-1/COX-2), thus preserving other prostaglandin syntheses. BM-573 also demonstrates a significant inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle. This compound is valuable for research applications in atherosclerosis, myocardial infarction, pulmonary hypertension, and shock. -
Prostaglandin Receptor Control
Alprostadil sodium is a ligand for prostaglandin receptors, demonstrating Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in murine models, respectively. This compound effectively promotes vasodilation and inhibits platelet aggregation, rendering it a valuable tool for research into peripheral vascular disease and its associated pathophysiology. Alprostadil sodium's vasodilatory properties make it significant for exploring therapeutic strategies in vascular disorders. -
Prostaglandin Receptor
Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost, a potent prostaglandin F2α analogue that acts as an agonist at the FP prostanoid receptor. This compound exhibits key biological activity in lowering intraocular pressure (IOP) and is extensively utilized in research focused on glaucoma treatment and ocular hypertension. Its role in prostaglandin receptor interactions makes it valuable for studying related therapeutic applications. -
Bcl-2 Modulator, PCNA Modulator, Oxidative Stress Inducer
Proquinazid is a Bcl-2 and PCNA modulator that acts as an oxidative stress inducer. It is known to induce genotoxic effects and promote apoptosis by influencing the balance of pro-apoptotic and anti-apoptotic proteins. This compound is utilized in research applications focusing on cellular responses to DNA damage and apoptosis mechanisms. -
EP2 Receptor Agonist
EP2 receptor agonist 4 is a selective agonist targeting the EP2 receptor, exhibiting an EC50 of 43 nM. This compound is instrumental in studying the roles of EP2 receptor activation in various biological processes, including inflammation and pain modulation. Its specificity allows for detailed investigations into the receptor's function and potential therapeutic applications in related diseases. -
PGD2 Antagonist
S-5751 is an orally active antagonist of the prostaglandin D2 (PGD2) receptor. It effectively inhibits cAMP generation in platelet-rich plasma induced by PGD2 with an IC50 of 0.12 μM. S-5751 demonstrates anti-inflammatory properties and is particularly useful in asthma research, providing insights into the modulation of inflammatory pathways. -
Bronchoconstrictor
16,16-Dimethylprostaglandin F2α is a potent bronchoconstrictor and a stable analog of prostaglandin F2α. It exhibits comparable binding affinity to PGF2α, facilitating studies on its biological activity and mechanisms of action. This compound is commonly utilized in research related to respiratory physiology and pharmacological assessments of bronchial constriction. -
Endogenous Hormone
Prostaglandin D2-1-glyceryl ester is a bioactive lipid mediator that serves as an endogenous hormone. It plays a critical role in various physiological processes, including regulation of inflammation and modulation of immune responses. This compound is utilized in research applications focused on the study of prostaglandin signaling pathways and their implications in cardiovascular and neuroinflammatory diseases. -
Thromboxane Antagonist
L 655240 is a potent thromboxane antagonist that plays a crucial role in modulating cardiovascular responses. It has been demonstrated to reduce early ischemia and reperfusion-induced arrhythmias in canine models of coronary artery occlusion. Additionally, L 655240 is being investigated for its potential applications in cancer and autoimmune disorders, highlighting its importance in diverse areas of biomedical research. -
EP2-Receptor Agonist
AH13205 is a selective agonist of the prostanoid EP2 receptor. It elicites concentration-dependent relaxations in Carbachol-contracted trachea, demonstrating its potential as a bronchodilator. Additionally, AH13205 provides dose-dependent protection against Histamine-induced increases in respiratory rate, indicating its utility in respiratory research applications. -
TxA2 Antagonist
L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, exhibiting high selectivity and potency. The compound consists of two enantiomers: (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid, with an IC50 of 0.27 nM, and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid, with an IC50 of 124 nM. L-657926 is utilized in research focused on thromboxane signaling pathways, cardiovascular disease studies, and the modulation of related biological processes. -
Dinoprost Metabolite
Tetranor-PGFM is a primary urinary metabolite of Dinoprost, serving as an important biochemical marker. It plays a crucial role in the monitoring of prostaglandin F biosynthesis and is utilized in research related to reproductive biology and inflammation. Tetranor-PGFM can provide insights into prostaglandin metabolism and the physiological effects associated with its regulation. -
EP1/EP3 Receptor Agonist
19(R)-Hydroxy prostaglandin E1 is an agonist of the EP1 and EP3 receptor subtypes. This compound is primarily involved in smooth muscle contractility, making it significant in studies related to reproductive biology and smooth muscle physiology. Its biological activity supports research into various physiological and pathological processes influenced by prostaglandins. -
Cyclopentenone Analog
Prostaglandin A1 methyl ester is a cyclopentenone analog that functions primarily as a modulator of inflammatory processes. It exhibits significant biological activity as an inducer of apoptosis and a potent anti-inflammatory agent. This compound is widely used in research applications focused on inflammation, cancer biology, and the study of prostaglandin pathways. -
Prostaglandin E1 Analogue
Rioprostil is a potent prostaglandin E1 analogue, primarily targeting the regulation of gastric acid secretion. It exhibits significant antisecretory effects, along with anti-gastric lesion properties, making it valuable for studies focused on mucosal protection. This compound serves as an important reagent in gastrointestinal research, particularly in understanding the mechanisms underlying gastric mucosal defense. -
IP Agonists
FK-788 is a potent PGI(2) and IP receptor agonist, exhibiting significant anti-aggregation activity with an IC50 of 18 nM. It demonstrates a high binding affinity for the human recombinant IP receptor, characterized by a Ki value of 20 nM. This compound is valuable for research applications focused on studying platelet aggregation and vascular function. -
PGF1α Metabolite
13,14-Dihydro-15-keto PGF1α is a metabolite of PGF1α that acts as a potent agonist of the prostaglandin F receptor. This compound plays a significant role in the regulation of various physiological processes, including vasodilation and smooth muscle contraction. It is particularly useful in biochemical research for studying the effects of prostaglandins on cellular functions and their implications in cardiovascular and reproductive biology. -
EP3 Receptor Antagonist
EP3 antagonist 2 is a potent and selective antagonist of the EP3 receptor, exhibiting a strong binding affinity with a Ki value of 3.3 nM. This compound demonstrates significant antagonistic activity, with an IC50 of 30.8 nM, as determined by its ability to modulate cellular cAMP levels. EP3 antagonist 2 is suitable for research applications exploring the physiological roles of the EP3 receptor in various biological processes and potential therapeutic interventions. -
TXA2 Synthase/TP-Receptor Inhibitor
ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP receptor). It exhibits significant biological activity in preventing thrombus formation by modulating arachidonic acid metabolism. ICI D1542 is utilized in research applications focused on cardiovascular diseases and thrombotic disorders, providing insights into the role of TXA2 in vascular biology. -
Thromboxane Receptor Agonist
AGN 191976 is a selective agonist of the thromboxane A2 (TP) receptor, exhibiting EC50 values of 0.23 nM in rat aorta and 24 nM in human platelets. This compound demonstrates significant intraocular pressure-lowering effects in canine and primate models. AGN 191976 serves as a valuable tool for investigating vascular biology and elucidating the role of thromboxane A2 in vascular function and related pathophysiological processes. -
PGF2α Analogue
16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable analogue of PGF2α, featuring an ethyl amide moiety that enhances its stability. This compound exhibits key biological activities, including the modulation of smooth muscle contraction and potential roles in reproductive health research. It is valuable for studies focused on prostaglandin signaling pathways and their implications in various physiological and pathological processes.
