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EP2 receptor agonist 2

EP2 Receptor Agonist

EP2 receptor agonist 2 (compound 18a) is a highly selective G protein-biased agonist of the EP2 receptor, demonstrating an EC50 of 13 nM for hEP2G protein activation and minimal interaction with the β-arrestin pathway (EC50 > 10000 nM). This compound exhibits remarkable selectivity for the EP2 receptor, with EC50 values greater than 10000 nM for hEP1, hEP3, hEP4, hIP, and hFP. It serves as a valuable tool for research in inflammation and pain pathways, facilitating studies on EP2 receptor signaling and its therapeutic potential.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	1807780-00-2
Applications	EP2 Receptor Agonist
Formula	C₁₉H₂₁NO₅S
Molecular Weight	375.44
SMILES	OC(C1=CSC([C@@H](CC2)O[C@](C[C@H]3O)([H])[C@@]2([H])[C@H]3COC4=CC=CC=C4)=N1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.