EP2 receptor agonist 2 (compound 18a) is a highly selective G protein-biased agonist of the EP2 receptor, demonstrating an EC50 of 13 nM for hEP2G protein activation and minimal interaction with the β-arrestin pathway (EC50 > 10000 nM). This compound exhibits remarkable selectivity for the EP2 receptor, with EC50 values greater than 10000 nM for hEP1, hEP3, hEP4, hIP, and hFP. It serves as a valuable tool for research in inflammation and pain pathways, facilitating studies on EP2 receptor signaling and its therapeutic potential.
EP2 receptor agonist 2 (compound 18a) is a highly selective G protein-biased agonist of the EP2 receptor, demonstrating an EC50 of 13 nM for hEP2G protein activation and minimal interaction with the β-arrestin pathway (EC50 > 10000 nM). This compound exhibits remarkable selectivity for the EP2 receptor, with EC50 values greater than 10000 nM for hEP1, hEP3, hEP4, hIP, and hFP. It serves as a valuable tool for research in inflammation and pain pathways, facilitating studies on EP2 receptor signaling and its therapeutic potential.
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