Fig. 1 · Structure
Documents & Downloads
FR-181877
PGI2 Agonist
FR-181877 is a selective PGI2 agonist that enhances prostacyclin signaling. It exhibits significant inhibitory activity on ADP-induced human platelet aggregation, with an IC50 value of 0.081 μM. This compound is valuable for research focusing on cardiovascular biology and hemostasis, offering insights into platelet function and potential therapeutic applications in thrombotic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 172936-99-1 |
| Applications | PGI2 Agonist |
| Formula | C30H28N2O4 |
| Molecular Weight | 480.55 |
| SMILES | OC(COC1=C(CC2)C(C[C@H]2CN(C(C=C3)=O)N=C3C(C4=CC=CC=C4)C5=CC=CC=C5)=CC=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.