Fig. 1 · Structure
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GW 848687X
EP1 Receptor Antagonist
GW 848687X is a selective antagonist of the prostaglandin EP1 receptor, primarily involved in the modulation of inflammatory pain. This orally active compound demonstrates significant bioavailability, achieving 54% in rats and 53% in dogs. With a half-life of 2 hours, GW 848687X exhibits potential in both acute and chronic pain management research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 612831-24-0 |
| Applications | EP1 Receptor Antagonist |
| Formula | C24H18ClF2NO3 |
| Molecular Weight | 441.85 |
| SMILES | O=C(C1=CC=CC(C2=C(CCC2)C3=C(OCC4=CC=C(C=C4F)F)C=CC(Cl)=C3)=N1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.