MI 63 is a potent p53 activator that functions by inhibiting the MDM2 protein with a Ki of 3 nM. This compound effectively reduces the proliferation of embryonic rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) cells, demonstrating an IC50 value of 0.58 μM in RH36 cells. Additionally, MI 63 promotes apoptosis in both ERMS and ARMS, making it a valuable tool for research in cancer biology and therapeutic development targeting p53 pathways.
MI 63 is a potent p53 activator that functions by inhibiting the MDM2 protein with a Ki of 3 nM. This compound effectively reduces the proliferation of embryonic rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS) cells, demonstrating an IC50 value of 0.58 μM in RH36 cells. Additionally, MI 63 promotes apoptosis in both ERMS and ARMS, making it a valuable tool for research in cancer biology and therapeutic development targeting p53 pathways.
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