mutant p53 (R175H) Activator, Metal Ion Chelator, Zinc Ionophore
ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore that specifically targets the mutant p53 protein (R175H) with a binding affinity (Ka) of 27.4 nM. This compound effectively facilitates the transport of zinc ions across cellular membranes and restores zinc binding to zinc-deficient p53 mutants, which can reinstate the wild-type structure and function necessary for site-specific DNA binding. Additionally, ZMC2 generates reactive oxygen species (ROS), making it a valuable tool for cancer research applications.
ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore that specifically targets the mutant p53 protein (R175H) with a binding affinity (Ka) of 27.4 nM. This compound effectively facilitates the transport of zinc ions across cellular membranes and restores zinc binding to zinc-deficient p53 mutants, which can reinstate the wild-type structure and function necessary for site-specific DNA binding. Additionally, ZMC2 generates reactive oxygen species (ROS), making it a valuable tool for cancer research applications.
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