P53R3 is a potent p53 reactivator that restores sequence-specific DNA binding in p53 hotspot mutants, including p53R175H, p53R248W, and p53R273H. It induces p53-dependent antiproliferative effects with greater specificity than other compounds. P53R3 enhances the recruitment of both wild-type p53 and the p53M237I variant to various target gene promoters, and it significantly increases the mRNA, total protein, and cell surface expression of the death receptor 5 (DR5). This reagent is utilized in cancer research to explore the therapeutic potential of p53 reactivation.
P53R3 is a potent p53 reactivator that restores sequence-specific DNA binding in p53 hotspot mutants, including p53R175H, p53R248W, and p53R273H. It induces p53-dependent antiproliferative effects with greater specificity than other compounds. P53R3 enhances the recruitment of both wild-type p53 and the p53M237I variant to various target gene promoters, and it significantly increases the mRNA, total protein, and cell surface expression of the death receptor 5 (DR5). This reagent is utilized in cancer research to explore the therapeutic potential of p53 reactivation.
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