VDR Agonist 1 is a nonsteroidal agonist of the Vitamin D receptor (VDR), exhibiting an IC50 of 690 nM in MCF-7 cells. This compound induces apoptosis by enhancing the expression of pro-apoptotic protein BAX while reducing anti-apoptotic protein Bcl-2 levels. Additionally, VDR Agonist 1 triggers cell cycle arrest through the up-regulation of cyclin-dependent kinase inhibitors p21 and p27, making it a valuable tool for studies related to cancer biology and therapeutic interventions targeting apoptotic pathways.
VDR Agonist 1 is a nonsteroidal agonist of the Vitamin D receptor (VDR), exhibiting an IC50 of 690 nM in MCF-7 cells. This compound induces apoptosis by enhancing the expression of pro-apoptotic protein BAX while reducing anti-apoptotic protein Bcl-2 levels. Additionally, VDR Agonist 1 triggers cell cycle arrest through the up-regulation of cyclin-dependent kinase inhibitors p21 and p27, making it a valuable tool for studies related to cancer biology and therapeutic interventions targeting apoptotic pathways.
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