Cytochrome P450

Cat. No.

A10279

CAS No.

1155361-11-7

Cytochrome P450 14a-demethylase inhibitor 1m

Cat. No.

A10280

CAS No.

1155361-12-8

Cytochrome P450 14a-demethylase inhibitor 1n

Cat. No.

A10446

CAS No.

52-86-8

Haloperidol

Synonyms: Haldol

Haloperidol (Haldol) is an antipsychotic and butyrophenone.

Cat. No.

A10498

CAS No.

65277-42-1

Ketoconazole

Synonyms: Nizoral; Extina; Xolegel; Kuric

As an antifungal, ketoconazole is structurally similar to imidazole, and interferes with the fungal synthesis of ergosterol, a constituent of fungal cell membranes, as well as certain enzymes.

Cat. No.

A10578

CAS No.

298-81-7

Methoxsalen

Synonyms: Xanthotoxin; Metoxaleno; Dltasoralen; Meladinine; Uvadex; Oxsoralen

Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450).

Cat. No.

A10688

CAS No.

82571-53-7

Ozagrel (OKY-046)

Synonyms: OKY-046

Ozagrel is a potent and selective thromboxane A2 synthetase inhibitor with an IC50 of 4 nM.

Cat. No.

A10744

CAS No.

171228-49-2

Posaconazole

Synonyms: Noxafil

Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14α demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.

Cat. No.

A10853

CAS No.

67920-52-9

Sodium Danshensu

Sodium danshensu is a sodium salt of danshensu from the widely used Chinese herb Danshen (Salvia miltiorrhiza Bunge). In vitro and in vivo studies revealed that danshensu possessed diverse pharmacological effects, including relaxation of coronary artery, anticoagulation, protection of myocardial ischemia-reperfusion injury, and antiarrhythmia activities

Cat. No.

A10978

CAS No.

137234-62-9

Voriconazole

Synonyms: Vfend; Pfizer

Voriconazole (Vfend) is a triazole antifungal agent that is available as a lyophilized powder for solution for intravenous infusion.

Cat. No.

A11044

CAS No.

566939-85-3

Orteronel (TAK-700)

Synonyms: TAK700

TAK-700 (Orteronel) is an oral, non-steroidal androgen synthesis inhibitor that selectively inhibits the 17,20 lyase enzyme.

Cat. No.

A11058

CAS No.

154229-18-2

Abiraterone Acetate (CB7630)

Synonyms: CB-7630

Abiraterone acetate (CB7630) is an orally active acetate ester of the steroidal compound Abiraterone with antiandrogen activity. Abiraterone inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1).

Cat. No.

A11138

CAS No.

851983-85-2

Galeterone (TOK-001)

Synonyms: VN/124-1; TOK-001

TOK-001 (Galeterone) is both an androgen receptor antagonist and CYP17A1 inhibitor.

Cat. No.

A11277

CAS No.

1004316-88-4

Cobicistat (GS-9350)

Synonyms: GS9350

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

Cat. No.

A11409

CAS No.

427-51-0

Cyproterone acetate

Cyproterone acetate is a synthetic derivative of 17-hydroxyprogesterone, and acts as an androgen receptor antagonist as well as a weak progesterone receptor agonist with weak progestational and glucocorticoid activity.

Cat. No.

A11481

CAS No.

187164-19-8

Luliconazole

Synonyms: NND 502; Lulicon

Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.

Cat. No.

A11835

CAS No.

25122-46-7

Clobetasol propionate

Clobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.

Cat. No.

A11977

CAS No.

24144-92-1

TMS

Synonyms: E)-2,3',4,5'-tetramethoxystilbene

TMS is a potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50= 6 nM). 5N/A- and 520-fold selective over P450 1A1 and 1A2 respectively.

Cat. No.

A12303

CAS No.

486-60-2

Bergaptol

Synonyms: 5-Hydroxypsoralen; 4-Hydroxybergapten

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.

Cat. No.

A12544

CAS No.

1390637-82-7

CYP3cide (PF 4981517)

Synonyms: PF4981517

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

Cat. No.

A12622

CAS No.

2093317-51-0

CYP17-IN-1

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM.

Cat. No.

A13113

CAS No.

870093-23-5

Talarozole R enantiomer

Synonyms: R115866; Rambazole

Talarozole R enantiomer inhibits the metabolism of retinoic acid by blocking the cytochrome P450 enzyme isoform CYP26, a retinoic acid hydroxylase.

Cat. No.

A13361

CAS No.

1614-12-6

ABT

Synonyms: 1-Aminobenzotriazole

ABT (1-Aminobenzotriazole )is a suicide substrate for (CYP)cytochrome P-450 and chloroperoxidase.

Cat. No.

A13365

CAS No.

117620-77-6

3-Cyano-7-ethoxycoumarin

Synonyms: 7-Ethoxycoumarin-3-carbonitrile

3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. It is a fluorescent probe useful in microsomal dealkylase studies.

Cat. No.

A13366

CAS No.

50-12-4

Mephenytoin

Mephenytoin is a CYP2C19 substrate. Anticonvulsant.

Cat. No.

A13367

CAS No.

5725-89-3

Methoxyresorufin

Synonyms: Resorufin methyl ether

Methoxyresorufin is a fluorometric substrate for cytochrome P450 linked enzymes.