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Cytochrome P450 (CYP) inhibitors act on heme enzymes that oxidize drugs, steroids and other lipophilic compounds. The name comes from the 450 nm absorption peak of a carbon monoxide-bound pigment, described in liver microsomes in 1964. Hepatic enzymes such as CYP3A4, CYP2C9 and CYP1A2 metabolize a large share of drugs and many environmental chemicals. Other members synthesize steroid hormones, among them CYP17A1, which is required for androgen production. The P450 system can also convert chemicals into toxic or carcinogenic metabolites, which links it closely to toxicology. Abiraterone inhibits CYP17A1, while clarithromycin and itraconazole serve as CYP3A4 inhibitors in drug-interaction studies. Alizarin is listed for its inhibition of enzymes in the CYP1 family.
Naringenin is a flavanone, a type of flavonoid, that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
Synonyms: SMT C1100; BMN 195; VOX-C1100
Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM .
Synonyms: (R)-Omeprazole; (+)-Omeprazole
(R)-Esomeprazole is an orally active modulator of cytochrome P450 enzymes, specifically targeting CYP2C19, CYP3A4, and CYP2C9. This compound is instrumental in studying metabolic processes and drug interactions, particularly in the context of digestive system diseases. Its ability to influence metabolic pathways makes it a valuable tool in pharmacological research.
Thienyldecyl Isothiocyanate serves as a cytochrome P450 modulator, demonstrating significant antiproliferative activity against cancer cells. This compound exerts its effects through the inhibition of cytochrome P450 enzymes and the induction of phase II detoxification enzymes, impacting xenobiotic metabolism. Thienyldecyl isothiocyanate is valuable for research in cancer biology and pharmacology, particularly in studies exploring enzyme modulation and its implications for drug metabolism and efficacy.
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