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Biological Activity
Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.04 mL | 125.21 mL | 250.41 mL |
| 0.5 mM | 5.01 mL | 25.04 mL | 50.08 mL |
| 1 mM | 2.5 mL | 12.52 mL | 25.04 mL |
| 5 mM | 0.5 mL | 2.5 mL | 5.01 mL |
*The above data is based on the productmolecular weight 399.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A20996 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1610537-15-9 |
| Formula | C18H17F4N3O3 |
| M. Wt | 399.34 |
| Purity | >98% |
| Synonyms | VT-464, VT464, VT 464 |
| SMILES | FC(F)OC1=C(OC(F)F)C=C(C=CC([[email protected]](C2=CNN=N2)(C(C)C)O)=C3)C3=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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