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Fig. 1 · Structure
Cat. No.
A20389
CAS No.
1821143-79-6
Formula
C18H13NO
Mol. Weight
259.3

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DMU2105

Cat. No. A20389 CAS 1821143-79-6

CYP1B1 inhibitor

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.

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Biological Activity

Target & Activity

Target Activity Value
CYP1B1 IC50 10 nM
CYP1A1 IC50 742 nM

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 IC50 0.004 μM Inhibition of human liver CYP1B1 expressed in HEK293 cells using CEC as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay [PMID: 28222316]
HEK293 IC50 0.053 μM Inhibition of human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate addition measured after 60 mins by fluorescence assay [PMID: 28222316]
HEK293 EC50 1 μM Inhibition of human CYP1B1 expressed in HEK293 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin EC50 at 0.02 uM by MTT assay (Rvb = 61 +/- 8 uM) [PMID: 28222316]
HEK293 EC50 8.5 μM Potentiation of cisplatin-induced cytotoxicity against HEK293 cells by measuring cisplatin EC50 at 10 times CYP1B1 inhibitory IC50 by MTT assay (Rvb = 8.7 +/- 0.7 uM) [PMID: 28222316]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1821143-79-6
Applications CYP1B1 inhibitor
Formula C18H13NO
Molecular Weight 259.3
SMILES
O=C(C1=CC=CN=C1)/C=C/C2=CC=C3C=CC=CC3=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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