Fig. 1 · Structure
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Protoporphyrin IX (disodium)
Cat. No.
A71827
CAS
50865-01-5
Endogenous Metabolite,Cancer Inhibitor
Protoporphyrin IX (disodium) is a key metabolite in the heme biosynthetic pathway, functioning primarily as a radiation sensitizer. It enhances the generation of reactive oxygen species (ROS) even under hypoxic conditions, thereby inducing DNA damage. This compound also serves as a photosensitizer, undergoing photodegradation when exposed to light. Notably, Protoporphyrin IX (disodium) accumulates in tumor cells following administration of 5-aminolevulinic acid (5-ALA) and demonstrates selective efficacy against basal cell carcinoma when activated at a wavelength of 405 nm. Its properties make it a valuable candidate for research into sonodynamic and photodynamic therapies for various cancers, including bladder cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 50865-01-5 |
| Applications | Endogenous Metabolite,Cancer Inhibitor |
| Formula | C34H32N4Na2O4 |
| Molecular Weight | 606.62 |
| Synonyms | PPIX (disodium) |
| SMILES | O=C(O[Na])CCC1=C2/C=C3C(CCC(O[Na])=O)=C(C)C(/C=C(N/4)/C(C)=C(C=C)C4=C\C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.