Fig. 1 · Structure
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CRCD2
Cat. No.
A71724
CAS
941185-83-7
Endogenous Metabolite
CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 941185-83-7 |
| Applications | Endogenous Metabolite |
| Formula | C17H16N4O2S |
| Molecular Weight | 340.40 |
| SMILES | O=C(C1=C(NC(C2=CC3=C(N=CN3)C=C2)=O)SC4=C1CCCC4)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.