CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia.
CRCD2 is a small molecule inhibitor of the nucleotidase NT5C2, enhancing the cytotoxic effects of 6-mercaptopurine. It effectively reverses resistance to 6-mercaptopurine caused by NT5C2 gene mutations or non-genetic mechanisms. When used in combination with 6-mercaptopurine, CRCD2 enhances cytotoxic activity in NT5C2 wild-type leukemia, indicating its potential as a therapeutic agent in the treatment of acute lymphoblastic leukemia.
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