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AubipyOMe

Catalog No.: A71718
Endogenous Metabolite
AubipyOMe is a selective inhibitor of tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme implicated in osteoclast and macrophage activity. It exhibits IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b, effectively inhibiting TRAP activity in murine macrophage extracts and human lung tissue. This compound is valuable for studying bone resorption and macrophage function in various biological contexts.
AubipyOMe 1221591-26-9 Endogenous Metabolite
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5mg
$265.00
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10mg
$435.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAubipyOMe is a selective inhibitor of tartrate-resistant acid phosphatase (TRAP/ACP5), a metalloenzyme implicated in osteoclast and macrophage activity. It exhibits IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b, effectively inhibiting TRAP activity in murine macrophage extracts and human lung tissue. This compound is valuable for studying bone resorption and macrophage function in various biological contexts.
Product Information
Catalog NumA71718
FormulaC12H12AuCl2F6N2O2P
Molecular Weight629.07
CAS Number1221591-26-9
SMILES[F-][P+5]([F-])([F-])([F-])([F-])[F-].[Cl-][Au+3]1([N]2=CC=C(C=C2C3=[N]1C=CC(OC)=C3)OC)[Cl-]
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Metabolism > Endogenous Metabolite