Catalog No.
Product Name
Application
Product Information
Citations
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Cy5 Derivative
Sulfo-Cy5-tetrazine is a Cy5 derivative featuring a tetrazine moiety that serves as a potent click chemistry reagent. This compound exhibits fluorescence properties similar to Cy5, with excitation/emission maxima at 633/647 nm. Sulfo-Cy5-tetrazine is optimized for use in biochemical applications requiring selective labeling, enabling the visualization of biomolecules through inverse electron demand Diels-Alder reactions with trans-cyclooctene (TCO) functionalized partners. This reagent is ideal for use in various biological research contexts, including molecular imaging and assay development. -
Red Fluorescent Dye
Janelia Fluor® 646, Tetrazine is a red fluorescent dye characterized by its tetrazine moiety. This compound serves as a versatile click chemistry reagent, enabling efficient labeling through inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing molecules. Its robust fluorescent properties make JF646, Tetrazine suitable for applications in cellular imaging, facilitating the visualization of dynamic biological processes in live cells. -
Near-Infrared Fluorescent Dye
Cyanine5.5 alkyne chloride is a near-infrared fluorescent dye that exhibits excitation at 678 nm and emission at 694 nm. This alkynyl-modified compound is particularly effective for click chemistry applications, enabling efficient labeling through reactions with azides. Its properties make it suitable for a variety of biological research applications, including imaging and tracking in live cells and tissues. -
Dye Reagent
DBCO-PEG12-TCO is a dual-functional click chemistry reagent featuring both DBCO and TCO moieties. The DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, while the TCO moiety is capable of engaging in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing compounds. This reagent is suitable for applications in bioconjugation, drug discovery, and the development of functionalized biomolecules in chemical biology research. -
BG-JQ1 Intermediate
BG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways. -
Dye
Alkyne MegaStokes dye 608 is a versatile fluorescent dye that enables effective labeling and visualization of biological samples. This dye is crucial for observing cell structures, tracking biomolecules, and evaluating various cellular functions. It can distinguish cell types, detect biomolecules, and study tissue pathology, making it valuable for both basic scientific research and clinical diagnostics. Additionally, Alkyne MegaStokes dye 608 finds applications in functional textile processing, food pigments, and dye-sensitized solar cells. -
Dye
Alkyne MegaStokes dye 735 is a multifunctional dye that serves as a critical tool for biological experiments. It facilitates the observation and analysis of cellular structures, tracking of biomolecules, and evaluation of cell functions. This dye is valuable for distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms. Its diverse applications extend from fundamental scientific research to clinical diagnostics and emerging fields such as functional textiles and dye-sensitized solar cells. -
Click Chemistry Reagent
Trisulfo-Cy5-Alkyne is a versatile click chemistry reagent featuring an alkyne group suitable for copper-catalyzed reactions. This compound exhibits near-infrared (NIR) fluorescence, making it ideal for biological imaging applications. Trisulfo-Cy5-Alkyne is primarily used in the conjugation of biomolecules, facilitating studies in cellular localization and molecular interactions within complex biological systems. -
Click Chemistry Reagent
Trisulfo-Cy5.5-Alkyne is a click chemistry reagent featuring an azide functional group, enabling its use in copper-catalyzed click reactions. This compound exhibits near-infrared (NIR) fluorescence, making it a valuable tool for various biological imaging applications. It is particularly useful for labeling biomolecules in live-cell studies, facilitating the visualization of cellular processes and interactions. -
Fluorescence Dye
Sulfo-Cy3-Tetrazine is a water-soluble cyanine fluorescence dye that features a tetrazine group for click chemistry applications. It functions through an inverse electron demand [4+2] cycloaddition reaction with trans-cyclooctene or other strained olefins, facilitating specific labeling and detection of biomolecules. This reagent is ideal for various applications in fluorescence microscopy, imaging, and other biological assays requiring precise and efficient molecular tagging. -
Click Chemistry Reagent
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent characterized by a methyltetrazine functionality. This compound serves as a fluorophore linker for trans-cyclooctene-based labeling applications, facilitating the visual tracking of biomolecules. It exhibits excellent stability at physiological pH and demonstrates high reactivity towards cyclooctene, making it suitable for a variety of biological and biochemical research applications, including target identification and protein labeling. -
Click Chemistry Reagent
Sulfo-Cy3-Methyltetrazine is a click chemistry reagent characterized by its methyltetrazine functionality and a water-soluble fluorescent dye. It exhibits excellent stability under physiological pH conditions, making it suitable for various biological applications. This reagent effectively couples with trans-cyclooctene and shows a high reactivity towards cyclooctene, enabling precise labeling and detection in live-cell imaging and other bioorthogonal applications. -
Fluorescent Probe
Alkyne-probe 1 is a fluorescent probe designed for click chemistry applications. Featuring an alkyne group, this reagent is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its ability to facilitate efficient labeling makes it a valuable tool for studying biomolecular interactions and visualizing cellular processes in various research applications. -
Fluorescent Dye
Coumarin-PEG2-endoBCN is a fluorescent dye that incorporates a coumarin fluorophore, functioning as a versatile click chemistry reagent. It exhibits strong fluorescence properties, making it suitable for various biological imaging applications. This compound can be utilized in the labeling of biomolecules, facilitating studies in cellular dynamics and molecular interactions. -
OXPHOS Inhibitor
Cyanine5 alkyne is a fluorescent dye that functions as an OXPHOS inhibitor, targeting mitochondrial respiration. This compound is primarily utilized in click chemistry applications, allowing for the labeling of azide-containing proteins and analysis of post-translational modifications, including glycosylation. Additionally, Cyanine5 alkyne has demonstrated potential to inhibit the growth of cancer stem cells, making it a valuable tool in cancer research and cellular biology studies. -
NIR Fluorescent Dye
Cyanine7 DBCO is a near-infrared fluorescent dye that acts as an efficient bio-orthogonal quencher. It is generated through the covalent linkage of the Cy7 fluorescent dye and the dibenzocyclooctyne (DBCO) moiety. In biochemical applications, Cyanine7 DBCO significantly decreases the fluorescence of N3-Cy5-COOH by 90% within 90 minutes, with observable signal reduction occurring as quickly as 2-5 minutes. This reagent is ideal for deep tissue imaging and advancing receptor-targeted therapeutic strategies in chemical research. -
Fluorochrome Dye
Cy5-PEG3-endo-BCN is a fluorochrome dye that features the Cyanine 5 (Cy5) structure with three polyethylene glycol (PEG) units. This compound includes the hydrophilic bidentate macrocyclic ligand endo-BCN, enabling the synthesis of macrocyclic complexes. In the context of click chemistry, endo-BCN readily reacts with azide-containing molecules to form stable triazole linkages without the need for catalytic conditions, making it a valuable tool for bioconjugation and labeling applications in chemical biology and biomedical research. -
Alkyne BODIPY
BODIPY-X-Alkyne is an alkyne-modified BODIPY derivative that exhibits strong fluorescence with excitation and emission maxima at 526 nm and 540 nm, respectively. This compound is specifically designed to undergo copper-catalyzed click reactions with azides, enabling versatile applications in bioconjugation and labeling studies. BODIPY-X-Alkyne is ideal for researchers investigating cellular imaging, biomolecular interactions, and the development of novel fluorescent probes. -
BODIPY Fluorophore
BODIPY FL alkyne is a bioorthogonal labeling reagent that targets azide groups on intracellular glycoconjugates through strain-promoted azide-alkyne cycloaddition (SPAAC). This alkyne-containing BODIPY fluorophore exhibits low toxicity and minimal non-specific reactivity, making it ideal for fluorescent bioimaging applications. BODIPY FL alkyne enables site-specific conjugation with proteins, such as IL-33, and supports positive cross-linking with probes for dual labeling studies. Its high specificity and low background interference make it valuable for researching conditions like asthma, atopic dermatitis, and inflammatory bowel disease. -
Fluorochrome Dye
Coumarin-C2-exo-BCN is a fluorochrome dye derivative of coumarin that features the lipophilic bidentate macrocyclic ligand exo-BCN. This compound enables the formation of macrocyclic complexes and plays a significant role in click chemistry, where it reacts with azide-containing molecules to produce stable triazoles without the need for catalysts. Coumarin-C2-exo-BCN is valuable in biological imaging and tracking applications, facilitating the study of molecular interactions and dynamics in various research contexts. -
Azide Reactive Probe
Cyanine3 DBCO hexafluorophosphate is an azide-reactive probe designed for bioconjugation applications through copper-free "click" chemistry. It enables selective and efficient labeling of azide-functionalized biomolecules, making it an invaluable tool for imaging and analyzing cellular processes. This reagent is particularly useful in studies involving bioorthogonal chemistry and can facilitate the visualization of complex biomolecular interactions. -
Fluorochrome Dye
Coumarin-C2-TCO is a fluorochrome dye that incorporates a TCO group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-tagged molecules. This reactivity allows for specific and efficient labeling in various biological applications, including live cell imaging and protein tagging. The versatility of Coumarin-C2-TCO makes it a valuable tool for studying dynamic cellular processes and enhancing fluorescent assay sensitivity. -
Fluorochrome Dye
Cy3-PEG2-endo-BCN is a fluorochrome dye derived from Cyanine 3 (Cy3) that incorporates two polyethylene glycol (PEG) units and the bidentate macrocyclic ligand endo-BCN. This structure enables its use in click chemistry, allowing it to react efficiently with azide-containing molecules to form stable triazole linkages without the need for catalysts. Cy3-PEG2-endo-BCN is ideal for various biological applications, including fluorescence labeling and imaging, facilitating the study of cellular processes and molecular interactions. -
Click Chemistry Reagent
Cy3 methyltetrazine is a click chemistry reagent that features methyltetrazine building blocks, known for its high reactivity towards cyclooctene. This tetrazine-modified fluorescent probe enables the analysis of protein phosphorylation both in solution and within living cells, making it a valuable tool for various biological research applications. Its unique properties facilitate targeted labeling and visualization in the study of protein dynamics and cellular processes. -
Click Chemistry Reagent
DiSulfo-Cy5 alkyne is a click chemistry reagent featuring a fluorescent dye. It enables efficient labeling of biomolecules through the copper-catalyzed azide-alkyne cycloaddition reaction. This compound is particularly useful in applications such as live-cell imaging, bioconjugation, and the development of fluorescent biosensors. Its strong fluorescence properties enhance the visibility of targeted structures in diverse biological research settings. -
Azide Reaction Probe
Cyanine 5 DBCO is an azide-reactive probe that facilitates copper-free "click" reactions for the imaging of azide-labeled biomolecules. This near-infrared (NIR) fluorescent dye exhibits low toxicity and does not adversely affect the physiological functions of non-target cells. With excitation at 635 nm and emissions ranging from 650 to 700 nm, Cyanine 5 DBCO is suitable for labeling and tracking cells in both in vitro and in vivo research applications. -
Fluorescent Dye
5-TAMRA-DBCO is a fluorescent dye featuring a 5-TAMRA core conjugated to a dibenzocyclooctyne (DBCO) moiety. This compound enables efficient copper-free click chemistry reactions with azide-functionalized biomolecules, facilitating precise bioconjugation. With emission and excitation wavelengths of 541 nm and 567 nm, respectively, 5-TAMRA-DBCO is ideal for labeling proteins, peptides, and nucleic acids, making it a valuable tool for various biological imaging and analysis applications. -
Fluorescent Dye
5-FITC-Tetrazine is a fluorescent dye that integrates fluorescein isothiocyanate (FITC) with tetrazine chemistry, enabling targeted labeling and imaging applications. This reagent offers enhanced fluorescent properties, making it suitable for a variety of biological assays, including live-cell imaging and fluorescence microscopy. Its stability and compatibility with diverse biomolecules make it a valuable tool for researchers in the field of cellular biology and biochemistry. -
Dye
Alkyne cyanine dye 718 is a multifunctional dye primarily utilized for fluorescence labeling in biological research. This dye enables researchers to visualize and analyze cellular structures, monitor biomolecular interactions, and distinguish between different cell types. Its versatility extends to applications in tissue pathology studies, microbial detection, and a variety of diagnostics in both basic and clinical research. Additionally, Alkyne cyanine dye 718 is relevant in innovative fields such as functional textiles, food coloring, and dye-sensitized solar cells. -
ADC Linker
BCN-linker-DXd 2 is a specialized ADC (antibody-drug conjugate) linker designed for targeted delivery of cytotoxic agents to cancer cells. This compound facilitates the conjugation of drugs to antibodies, enhancing specificity and reducing off-target effects in cancer therapy. It is applicable in research focused on ADC development and optimization for improved therapeutic efficacy against various types of tumors. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-MMAE is a conjugate designed for use in antibody-drug conjugate (ADC) synthesis, incorporating a drug-linker element. The DBCO component facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. The included MMAE moiety, a potent inhibitor of tubulin polymerization derived from dolastatin 10, exhibits significant mitotic inhibition. This reagent is ideal for advancing research in targeted cancer therapies by enabling the precise delivery of cytotoxic agents to tumor cells. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-GGFG-Dxd is a drug-linker conjugate targeting antibody-drug conjugates (ADCs) with potent antitumor activity derived from the DNA topoisomerase I inhibitor Dxd. This compound utilizes a cleavable linker, DBCO-PEG4-GGFG, which enhances selective delivery of the therapeutic agent. DBCO-PEG4-GGFG-Dxd serves as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it a valuable tool in bioconjugation applications. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-Val-Cit-PAB-MMAF is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs) that combines a cleavable PEG linker with the potent tubulin polymerization inhibitor MMAF. The DBCO moiety facilitates efficient synthesis through click chemistry, specifically strain-promoted alkyne-azide cycloaddition (SPAAC), allowing for precise conjugation to azide-containing biomolecules. This reagent is essential for enhancing the therapeutic efficacy of ADCs by enabling targeted delivery of cytotoxic agents. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-MMAF is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, utilizing MMAF as a potent tubulin polymerization inhibitor. The conjugate features a cleavable linker, DBCO-PEG4, which facilitates the selective release of MMAF within target cells. DBCO-PEG4-MMAF serves as a click chemistry reagent, containing a DBCO group that efficiently engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-modified molecules, making it a valuable tool for targeted therapeutics in cancer research. -
Drug-Linker Conjugates for ADC
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound features Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, linked to a cleavable DBCO-(PEG2-VC-PAB)2 linker. The DBCO group enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted delivery of cytotoxic agents. Its application is crucial for research in cancer therapeutics, particularly in enhancing the efficacy and selectivity of ADCs. -
Drug-Linker Conjugate For ADC
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a cleavable linker (TCO-PEG4-VC-PA) that facilitates the release of the potent tubulin inhibitor MMAE upon cellular internalization. TCO-PEG4-VC-PAB-MMAE incorporates a TCO group suitable for inverse electron demand Diels-Alder (iEDDA) reactions, enabling highly specific conjugation with tetrazine-containing molecules, thus enhancing therapeutic efficacy in targeted treatments. -
Drug-Linker Conjugate for ADC
DBCO-(PEG)3-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features Monomethyl auristatin E (MMAE) linked to a DBCO-(PEG)3-VC-PAB structure, facilitating targeted drug delivery in cancer research. As a click chemistry reagent, it utilizes a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable in bioconjugation applications. -
Drug-Linker Conjugate for ADC
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound combines the DBCO-PEG3-VC linker with Exatecan, a potent inhibitor of DNA topoisomerase I. Its structure facilitates targeted delivery of the cytotoxic agent to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects. Research applications include the development of ADCs for cancer treatment, providing a strategic tool for targeted therapy and molecular oncology studies. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-VA-PBD is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound utilizes the potent antitumor antibiotic Pyrrolobenzodiazepine (PBD), which is linked via a DBCO-PEG4-VA spacer. DBCO-PEG4-VA-PBD acts as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This functionality supports the development of targeted therapies for cancer treatment, enhancing the efficacy of ADCs. -
Drug-Linker Conjugates for ADC
endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable linker specifically designed for antibody-drug conjugates (ADCs), facilitating the targeted delivery of therapeutic agents. This compound features a 4-unit polyethylene glycol (PEG) chain and incorporates a BCN group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatility is highly applicable in the development of ADCs, enhancing the efficacy and specificity of cancer therapies. -
ADC Drug-Linker Conjugate
DBCO-Val-Cit-PAB-MMAE is an ADC drug-linker conjugate designed for the synthesis of antibody-drug conjugates (ADCs). It incorporates the tubulin inhibitor MMAE, which acts as a cytotoxic agent targeting rapidly dividing cells. The DBCO-Val-Cit-PAB linker features an electrophilic group, facilitating stable conjugation to antibodies and enhancing the therapeutic efficacy of ADCs in cancer research applications. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It combines the DBCO-PEG4-VC-PAB linker with the potent cytotoxin DMEA-PNU-159682, which includes active metabolites of nemorubicin. This compound leverages click chemistry, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 serves as an effective tool in targeted cancer therapy research and the development of innovative ADCs. -
Drug-Linker Conjugate for ADC
BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound incorporates a cleavable linker and the microtubule inhibitor MMAE, facilitating targeted delivery of cytotoxic agents to cancer cells. BCN-HS-PEG2(vcPABC-MMAE)2 is vital for researchers involved in the development and synthesis of ADCs, enhancing therapeutic efficacy while minimizing systemic toxicity. -
Drug-Linker Conjugate for ADC
DBCO-β-Glu-PEG12-Exatecan serves as a drug-linker conjugate specifically designed for antibody-drug conjugates (ADCs). This compound acts as a potent inhibitor of topoisomerase I, effectively disrupting DNA replication and transcription processes. Its unique structure allows for targeted delivery in therapeutic applications, making it suitable for research in cancer treatment and other malignancies. This reagent provides a valuable tool for the development and optimization of ADC formulations. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VA-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It features a potent tubulin inhibitor, MMAE, linked via a cleavable moiety, DBCO-PEG4-VA-PABC, facilitating targeted delivery to cancer cells. This conjugate is suitable for the synthesis of ADCs, demonstrating potential application in targeted cancer therapies by enhancing therapeutic efficacy while minimizing systemic toxicity. -
Anticancer Agent
DBCO-PEG3-GGFG-Exatecan is a drug-linker conjugate designed for use in antibody-drug conjugate (ADC) applications. This compound features the DBCO-PEG3-GGFG linker combined with Exatecan, a potent DNA topoisomerase I inhibitor. It is engineered to enhance the targeted delivery of cytotoxic agents to cancer cells, thereby improving therapeutic efficacy. DBCO-PEG3-GGFG-Exatecan is suited for research in cancer biology and the development of novel treatment strategies. -
Drug-Linker Conjugate
DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that incorporates the potent microtubulin inhibitor DM1, designed to facilitate antibody-drug conjugate (ADC) development. DM1, a maytansinoid, targets microtubules to inhibit cancer cell proliferation while minimizing systemic toxicity. The DBCO moiety in this compound allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing biomolecules, enabling efficient conjugation for targeted delivery in cancer research applications. -
Drug-linker Conjugate for ADC
DBCO-PEG3-Glu-VC-PABC-MMAF is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). It features the tubulin inhibitor MMAF linked through a cathepsin cleavable DBCO-PEG3-Glu-VC-PABC moiety, facilitating targeted delivery of the cytotoxic agent. This compound is valuable for research applications focusing on the development of ADCs, enabling studies on efficacy, mechanism of action, and therapeutic potential in cancer treatment. -
Click Reaction Agent
Mivebresib-alkyne functions as a Click Reaction Agent, facilitating the synthesis of BRD4-targeted PROTACs. This derivative of Mivebresib serves as an important tool for researchers investigating targeted protein degradation pathways and their potential therapeutic applications. Its unique alkyne functionality enables efficient conjugation reactions, enhancing the versatility of PROTAC development in chemical biology studies. -
Drug-linker Conjugate
DBCO-PEG3-Glu-Val-Cit-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound incorporates the potent tubulin inhibitor Monomethyl auristatin E (MMAE), facilitating targeted delivery in cancer therapeutics. Its structural features enable effective synthesis of dual-drug ADCs, enhancing cytotoxic efficacy while minimizing off-target effects.
