Catalog No.
Product Name
Application
Product Information
Citations
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Fluorescent Dye
Coumarin-PEG2-endoBCN is a fluorescent dye that incorporates a coumarin fluorophore, functioning as a versatile click chemistry reagent. It exhibits strong fluorescence properties, making it suitable for various biological imaging applications. This compound can be utilized in the labeling of biomolecules, facilitating studies in cellular dynamics and molecular interactions. -
OXPHOS Inhibitor
Cyanine5 alkyne is a fluorescent dye that functions as an OXPHOS inhibitor, targeting mitochondrial respiration. This compound is primarily utilized in click chemistry applications, allowing for the labeling of azide-containing proteins and analysis of post-translational modifications, including glycosylation. Additionally, Cyanine5 alkyne has demonstrated potential to inhibit the growth of cancer stem cells, making it a valuable tool in cancer research and cellular biology studies. -
NIR Fluorescent Dye
Cyanine7 DBCO is a near-infrared fluorescent dye that acts as an efficient bio-orthogonal quencher. It is generated through the covalent linkage of the Cy7 fluorescent dye and the dibenzocyclooctyne (DBCO) moiety. In biochemical applications, Cyanine7 DBCO significantly decreases the fluorescence of N3-Cy5-COOH by 90% within 90 minutes, with observable signal reduction occurring as quickly as 2-5 minutes. This reagent is ideal for deep tissue imaging and advancing receptor-targeted therapeutic strategies in chemical research. -
Fluorochrome Dye
Cy5-PEG3-endo-BCN is a fluorochrome dye that features the Cyanine 5 (Cy5) structure with three polyethylene glycol (PEG) units. This compound includes the hydrophilic bidentate macrocyclic ligand endo-BCN, enabling the synthesis of macrocyclic complexes. In the context of click chemistry, endo-BCN readily reacts with azide-containing molecules to form stable triazole linkages without the need for catalytic conditions, making it a valuable tool for bioconjugation and labeling applications in chemical biology and biomedical research. -
Alkyne BODIPY
BODIPY-X-Alkyne is an alkyne-modified BODIPY derivative that exhibits strong fluorescence with excitation and emission maxima at 526 nm and 540 nm, respectively. This compound is specifically designed to undergo copper-catalyzed click reactions with azides, enabling versatile applications in bioconjugation and labeling studies. BODIPY-X-Alkyne is ideal for researchers investigating cellular imaging, biomolecular interactions, and the development of novel fluorescent probes. -
BODIPY Fluorophore
BODIPY FL alkyne is a bioorthogonal labeling reagent that targets azide groups on intracellular glycoconjugates through strain-promoted azide-alkyne cycloaddition (SPAAC). This alkyne-containing BODIPY fluorophore exhibits low toxicity and minimal non-specific reactivity, making it ideal for fluorescent bioimaging applications. BODIPY FL alkyne enables site-specific conjugation with proteins, such as IL-33, and supports positive cross-linking with probes for dual labeling studies. Its high specificity and low background interference make it valuable for researching conditions like asthma, atopic dermatitis, and inflammatory bowel disease. -
Fluorochrome Dye
Coumarin-C2-exo-BCN is a fluorochrome dye derivative of coumarin that features the lipophilic bidentate macrocyclic ligand exo-BCN. This compound enables the formation of macrocyclic complexes and plays a significant role in click chemistry, where it reacts with azide-containing molecules to produce stable triazoles without the need for catalysts. Coumarin-C2-exo-BCN is valuable in biological imaging and tracking applications, facilitating the study of molecular interactions and dynamics in various research contexts. -
Azide Reactive Probe
Cyanine3 DBCO hexafluorophosphate is an azide-reactive probe designed for bioconjugation applications through copper-free "click" chemistry. It enables selective and efficient labeling of azide-functionalized biomolecules, making it an invaluable tool for imaging and analyzing cellular processes. This reagent is particularly useful in studies involving bioorthogonal chemistry and can facilitate the visualization of complex biomolecular interactions. -
Fluorochrome Dye
Coumarin-C2-TCO is a fluorochrome dye that incorporates a TCO group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-tagged molecules. This reactivity allows for specific and efficient labeling in various biological applications, including live cell imaging and protein tagging. The versatility of Coumarin-C2-TCO makes it a valuable tool for studying dynamic cellular processes and enhancing fluorescent assay sensitivity. -
Fluorochrome Dye
Cy3-PEG2-endo-BCN is a fluorochrome dye derived from Cyanine 3 (Cy3) that incorporates two polyethylene glycol (PEG) units and the bidentate macrocyclic ligand endo-BCN. This structure enables its use in click chemistry, allowing it to react efficiently with azide-containing molecules to form stable triazole linkages without the need for catalysts. Cy3-PEG2-endo-BCN is ideal for various biological applications, including fluorescence labeling and imaging, facilitating the study of cellular processes and molecular interactions. -
Click Chemistry Reagent
Cy3 methyltetrazine is a click chemistry reagent that features methyltetrazine building blocks, known for its high reactivity towards cyclooctene. This tetrazine-modified fluorescent probe enables the analysis of protein phosphorylation both in solution and within living cells, making it a valuable tool for various biological research applications. Its unique properties facilitate targeted labeling and visualization in the study of protein dynamics and cellular processes. -
Click Chemistry Reagent
DiSulfo-Cy5 alkyne is a click chemistry reagent featuring a fluorescent dye. It enables efficient labeling of biomolecules through the copper-catalyzed azide-alkyne cycloaddition reaction. This compound is particularly useful in applications such as live-cell imaging, bioconjugation, and the development of fluorescent biosensors. Its strong fluorescence properties enhance the visibility of targeted structures in diverse biological research settings. -
Azide Reaction Probe
Cyanine 5 DBCO is an azide-reactive probe that facilitates copper-free "click" reactions for the imaging of azide-labeled biomolecules. This near-infrared (NIR) fluorescent dye exhibits low toxicity and does not adversely affect the physiological functions of non-target cells. With excitation at 635 nm and emissions ranging from 650 to 700 nm, Cyanine 5 DBCO is suitable for labeling and tracking cells in both in vitro and in vivo research applications. -
Fluorescent Dye
5-TAMRA-DBCO is a fluorescent dye featuring a 5-TAMRA core conjugated to a dibenzocyclooctyne (DBCO) moiety. This compound enables efficient copper-free click chemistry reactions with azide-functionalized biomolecules, facilitating precise bioconjugation. With emission and excitation wavelengths of 541 nm and 567 nm, respectively, 5-TAMRA-DBCO is ideal for labeling proteins, peptides, and nucleic acids, making it a valuable tool for various biological imaging and analysis applications. -
Fluorescent Dye
5-FITC-Tetrazine is a fluorescent dye that integrates fluorescein isothiocyanate (FITC) with tetrazine chemistry, enabling targeted labeling and imaging applications. This reagent offers enhanced fluorescent properties, making it suitable for a variety of biological assays, including live-cell imaging and fluorescence microscopy. Its stability and compatibility with diverse biomolecules make it a valuable tool for researchers in the field of cellular biology and biochemistry. -
Dye
Alkyne cyanine dye 718 is a multifunctional dye primarily utilized for fluorescence labeling in biological research. This dye enables researchers to visualize and analyze cellular structures, monitor biomolecular interactions, and distinguish between different cell types. Its versatility extends to applications in tissue pathology studies, microbial detection, and a variety of diagnostics in both basic and clinical research. Additionally, Alkyne cyanine dye 718 is relevant in innovative fields such as functional textiles, food coloring, and dye-sensitized solar cells. -
Fluorochrome Dye
Coumarin-PEG3-TCO is a fluorochrome dye that incorporates three PEG units to enhance solubility and stability. Its TCO group facilitates an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-bearing molecules, making it ideal for bioorthogonal labeling applications. This reagent is particularly useful in fluorescence microscopy and tracking cellular processes in live cells. -
Fluorochrome Dye
Coumarin-PEG2-TCO is a fluorescent dye that features a coumarin backbone modified with two PEG units. It utilizes a trans-cyclooctene (TCO) group to engage in an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing compounds. This compound is valuable in biological imaging applications and has potential uses in the development of targeted fluorescent probes for live-cell imaging and other bioconjugation strategies. -
Protein Label
diSulfo-Cy3 alkyne is a water-soluble dye that functions as a Click Chemistry reagent featuring an alkyne group. With absorption and emission characteristics comparable to those of the Cy3 fluorophore, it is suitable for precise labeling of proteins and other biological structures in aqueous environments. This compound is valuable for applications in fluorescence microscopy and bioconjugation studies, enhancing visualization and tracking of target biomolecules in diverse biological research. -
Dye
Sulfo-Cy5-TCO is a water-soluble fluorescent dye that incorporates a trans-cyclooctene (TCO) moiety, facilitating rapid and efficient click chemistry reactions with tetrazines and methyltetrazines. This reagent is designed for use in bioconjugation applications, offering high reactivity and speed that enhances labeling efficiency in various biological experiments. Its unique properties make Sulfo-Cy5-TCO valuable for researchers in fields such as cellular imaging, biomolecule tracking, and targeted drug delivery. -
Azide-Labelled Probe
Cy5 DBCO chloride is a DBCO-based probe designed for applications involving azide-labeled biomolecules. It facilitates copper-free "Click Chemistry" through strain-promoted alkyne-azide cycloaddition (SPAAC), enabling efficient imaging of azide-modified targets. This reagent is particularly valuable for studies involving bioorthogonal labeling and tracking of biomolecules in various research applications, including cellular visualization and bioimaging. -
Alkyne Modified BODIPY TMR-X
BODIPY TMR-X alkyne is an alkyne-modified fluorescent dye that exhibits strong orange fluorescence. It is designed to react with azides through the copper-catalyzed click reaction, enabling specific labeling and tracking in biological systems. With its stable properties across various pH conditions, BODIPY TMR-X alkyne is suitable for a range of applications in live-cell imaging, chemical biology, and other research requiring fluorescent tagging and detection. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
Dye
Dde Biotin-PEG4-TAMRA-PEG4 Alkyne is a dye derivative of TAMRA designed for fluorescent applications, featuring a cleavable biotin moiety. This compound contains alkyne groups that facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its use in a variety of conjugation strategies. It is ideal for research applications involving biomolecular labeling and tracking in cellular and molecular studies. -
Dye
TAMRA-PEG4-methyltetrazine is a fluorescent dye derivative that features a tetrazine moiety for selective labeling applications. The presence of four polyethylene glycol (PEG) units enhances solubility and stability. This compound is designed to undergo inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners, making it suitable for bioconjugation and imaging studies in chemical biology research. -
Dye
TAMRA-PEG4-Alkyne is a fluorescent dye derivative of TAMRA that incorporates four PEG units, enhancing its solubility and biocompatibility. This compound features alkyne functional groups, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. Its unique properties make it valuable for various biological applications, including the labeling of biomolecules and the study of cellular processes through fluorescence imaging. -
Fluorescent Dye
TAMRA DBCO, 5-isomer is a fluorescent dye derivative of tetramethylrhodamine (TMR) featuring a dibenzocyclooctyne (DBCO) moiety. It enables rapid and efficient labeling of azide-containing biomolecules through a sterically promoted azide-alkyne cycloaddition (SPAAC) reaction, eliminating the need for copper catalysts. This compound is suitable for a wide range of applications, including the labeling of proteins, peptides, and nucleic acids, facilitating advanced studies in biochemistry and cellular imaging. -
Fluorescent Dye
OG 488 alkyne is a highly sensitive green-fluorescent dye designed for imaging azide-labeled biomolecules. It participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) to create a stable triazole linkage. This reagent is valuable for visualizing biomolecular interactions and dynamics, making it suitable for various applications in cellular imaging and bioconjugation studies. -
Fluorescent Dye
BP Fluor 488 TCO is a fluorescent dye that participates in the inverse-electron demand Diels-Alder cycloaddition reaction, reacting rapidly and selectively with tetrazines to form stable covalent linkages. This biocompatible reaction occurs without the need for copper catalysts or elevated temperatures, exhibiting an exceptionally high reaction rate constant (k > 800 M-1 s-1). BP Fluor 488 TCO is ideal for applications in bioorthogonal labeling, visualization, and tracking of biomolecules in live cells and various biological studies. -
Fluorescent Dye
ROX alkyne, 6-isomer is an alkyne derivative of the red-emitting fluorescent dye ROX (Rhodamine X, Rhodamine 101), known for its high quantum yield. This compound is particularly useful for fluorescent labeling of azide-containing biomolecules through copper-catalyzed click chemistry. Its applications include quantitative PCR and microscopy, making it an essential reagent for advanced imaging and detection in biochemical research. -
Fluorescent Dye
Cy7 alkyne chloride is a fluorescent dye derivative of Cyanine 7 (Cy7) featuring an alkyne functional group, with an excitation/emission wavelength of 740/770 nm. This reagent can undergo click chemistry reactions with azide-containing molecules, enabling the formation of stable covalent bonds. It is widely utilized in fluorescence imaging, bioconjugation applications, and cellular labeling studies, making it a valuable tool for researchers in bioorthogonal chemistry and related fields. -
click chemistry
FAM alkyne, 6-isomer is a click chemistry reagent designed for specific applications in 1,3-dipolar cycloaddition reactions with azido-labeled compounds. It facilitates the efficient formation of stably linked conjugates, making it a vital tool for bioconjugation studies and labeling in biological research. This compound is suitable for various applications, including imaging, drug delivery, and the development of biosensors. -
Azide Reaction Probe
Cyanine5 DBCO hexafluorophosphate is an azide-reactive probe designed for copper-free "click" reactions, enabling the selective imaging of azide-labeled biomolecules. This near-infrared fluorescent dye exhibits low toxicity to cells, making it suitable for both in vitro and in vivo applications without compromising the physiological functions of non-target cells. Its optimal excitation and emission wavelengths (Ex=635 nm, Em=650-700 nm) facilitate efficient cellular labeling and tracking, providing valuable insights in biological research. -
ADC Linker
DBCO-PEG3-TCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), featuring a 3-unit polyethylene glycol (PEG) spacer. This reagent facilitates click chemistry through its dibenzocyclooctyne (DBCO) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized compounds. Additionally, the TCO group supports inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules, making DBCO-PEG3-TCO a versatile tool for advancing ADC development in therapeutic research. -
Alkyne-conjugated Benzylguanine
Alkyne-SNAP is an alkyne-conjugated benzylguanine that serves as a reactive probe for SNAP-tag fusion proteins. The benzylguanine component enables irreversible and covalent labeling, facilitating the study of protein dynamics and interactions. This reagent is particularly valuable for applications involving click chemistry, allowing the introduction of further functional groups for bioconjugation and subsequent analyses in various biological research contexts. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NH-Boc is a versatile PROTAC linker featuring a cleavable structure designed for the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound utilizes a DBCO moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its PEG4 spacer enhances solubility and stability, making it suitable for various biological applications in drug development and therapeutic research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-amine is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of payloads such as MMAE to antibodies, enhancing targeted delivery to cancer cells. It has demonstrated compelling biological activities, with EC50 values of 280 nM and 22 nM for DBCO-VCpAB MMAE and DBCO-TRX MMAE, respectively, in SKBR3 cells, making it a valuable tool for researchers investigating targeted therapies. -
ADC Linker
BCN-exo-PEG3-maleimide is an ADC linker featuring three PEG units and a bidentate macrocyclic ligand, BCN. It facilitates the formation of stable triazole structures through click chemistry with azide-containing molecules, eliminating the need for catalysts. The maleimide moiety is designed to degrade in aqueous conditions, making it suitable for various drug delivery applications and enhancing the efficacy of antibody-drug conjugates (ADCs) in targeted therapy research. -
PROTAC Linkers
DBCO-N-bis(PEG4-NHS ester) is a bifunctional polyethylene glycol (PEG) linker featuring two NHS ester groups and a dibenzocyclooctyne (DBCO) moiety. This reagent facilitates protein modification and labeling, enhancing bioconjugation applications. As a click chemistry tool, DBCO-N-bis(PEG4-NHS ester) enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable for constructing PROTAC molecules and other bioorthogonal conjugates in various biochemical research settings. -
ADC Linker
bis-PEG2-endo-BCN is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a cyclooctyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling precise conjugation. Its implementation in ADC development enhances targeted delivery of therapeutics, making it valuable for research applications in oncology and drug development. -
Click Chemical Agent
DBCO-PEG24-acid is a click chemistry reagent that incorporates a dibenzocyclooctyne (DBCO) group linked to a hydrophilic polyethylene glycol (PEG) chain. This compound facilitates copper-free click reactions, leveraging the high energy associated with the DBCO moiety for efficient bioconjugation. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amines in the presence of coupling agents such as EDC or HATU. It is a valuable tool in bioconjugation studies and the development of drug delivery systems. -
ADC linker
DBCO-NHS Ester 3 is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. DBCO-NHS Ester 3 is utilized in various applications involving targeted drug delivery and bioconjugation strategies in chemical biology and therapeutic development. -
ADC Linker
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). It features a tetrazine moiety that facilitates rapid and selective conjugation through an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives. This compound enhances the stability and efficacy of ADCs, making it valuable for targeted delivery of therapeutics in cancer research and other applications in bioconjugation. -
Click Chemistry Intermediate
DBCO-C3-Acid is a versatile Click Chemistry intermediate that serves as a key component in the development of antibody-drug conjugate (ADC) linkers. Its chemical structure facilitates efficient conjugation processes, enabling precise attachment of cytotoxic agents to antibodies. This reagent is essential for advancing research in targeted cancer therapeutics and improving drug delivery systems. -
ADC Linker
Aminooxy-PEG2-BCN is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This reagent features a BCN (cyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique structure enables efficient conjugation in the development of targeted therapeutics, enhancing both delivery and efficacy of payloads in cancer research and other biomedical applications. -
ADC Linker
Mal-bis-PEG3-DBCO is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, functioning through the efficient coupling of DBCO and azide moieties. This reagent incorporates a 3-unit polyethylene glycol (PEG) chain, enhancing solubility and biocompatibility. Its mechanism relies on strain-promoted alkyne-azide cycloaddition (SPAAC), making it ideal for precise conjugation applications in targeted drug delivery and cancer therapeutics research. -
PROTAC Linker
PC Alkyne-PEG4-NHS ester is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Functioning as a PROTAC linker, this reagent features an alkyne group and participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its unique structure enhances the specificity and efficiency of conjugating azide-containing molecules, making it valuable for various chemical biology applications, including targeted drug delivery and proteolysis targeting chimera (PROTAC) development. -
PROTAC Linker
TCO-PEG4-DBCO is a versatile PROTAC linker known for its ability to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds, while the TCO component allows for inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine derivatives. TCO-PEG4-DBCO finds applications in the development of antibody-drug conjugates (ADCs), enhancing the precision and efficacy of targeted therapeutics. Its unique chemical properties make it a valuable tool for researchers in chemical biology and drug development. -
ADC Linker
Mal-PEG2-bis-PEG3-BCN is a cleavable linker designed for use in antibody-drug conjugates (ADCs). Featuring a BCN moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enhancing conjugation efficiency. This reagent is ideal for the development of targeted therapies in cancer research and other applications requiring precise drug delivery mechanisms. -
ADC Linker
TCO-SS-amine is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring a TCO group, this reagent facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules. Its selective and efficient coupling capabilities make TCO-SS-amine a valuable tool in ADC development, enabling targeted delivery of therapeutic agents in cancer research and drug discovery applications.
