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Mal-bis-PEG3-DBCO

Catalog No.: A42991
ADC Linker
Mal-bis-PEG3-DBCO is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, functioning through the efficient coupling of DBCO and azide moieties. This reagent incorporates a 3-unit polyethylene glycol (PEG) chain, enhancing solubility and biocompatibility. Its mechanism relies on strain-promoted alkyne-azide cycloaddition (SPAAC), making it ideal for precise conjugation applications in targeted drug delivery and cancer therapeutics research.
Mal-bis-PEG3-DBCO 2882973-12-6 ADC Linker
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Size Price Stock Qty
25mg
$840.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-bis-PEG3-DBCO is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, functioning through the efficient coupling of DBCO and azide moieties. This reagent incorporates a 3-unit polyethylene glycol (PEG) chain, enhancing solubility and biocompatibility. Its mechanism relies on strain-promoted alkyne-azide cycloaddition (SPAAC), making it ideal for precise conjugation applications in targeted drug delivery and cancer therapeutics research.
Product Information
Catalog NumA42991
FormulaC70H84N8O17
Molecular Weight1309.46
CAS Number2882973-12-6
SMILESO=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCNC(CCOCC(NC(CCN4C(C=CC4=O)=O)=O)COCCC(NCCOCCOCCOCCNC(CCC(N5C6=CC=CC=C6C#CC7=CC=CC=C7C5)=O)=O)=O)=O)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Antibody-drug Conjugates (ADC) > ADC Linker
Click Chemistry > DBCO