Catalog No.
Product Name
Application
Product Information
Citations
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Bifunctional Chelating Agent
Deferoxamine-DBCO is a bifunctional chelating agent that effectively binds to radioactive metals, such as 89Zr, via its deferoxamine (DFO) structure for radiolabeling applications. Additionally, it facilitates metal-free Huisgen cycloaddition reactions with azide-containing biomolecules, including siRNA and monoclonal antibodies, through its dibenzocyclooctyne (DBCO) moiety under bioorthogonal conditions. This reagent combines robust metal-chelating capabilities with specific bioorthogonal reactivity, making it suitable for targeted radioactive imaging studies in oncology research. -
Bifunctional Chelator
BCN-NODAGA is a bifunctional chelator that effectively binds to radionuclides, facilitating the formation of radionuclide conjugates (RDCs). This compound allows for targeted delivery to biomolecules, making it a valuable tool for medical imaging applications and therapeutic strategies. Its ability to form stable complexes enhances its utility in radiopharmaceutical development for diagnostics and treatment in oncology and other diseases. -
Bifunctional Chelator
BCN-DOTA is a bifunctional chelator that features a cyclooctyne linkage, allowing for the efficient radiolabeling with zirconium-89. This compound serves as a versatile radionuclide-labeled drug conjugate (RDC) designed for targeting specific biomolecules, cells, or tissues in vivo. BCN-DOTA is applicable in various research fields, including theranostics, molecular imaging, and targeted radiotherapy, enabling precise delivery and tracking of therapeutic agents. -
Bifunctional Chelator
BCN-DOTA-GA is a bifunctional chelator characterized by a cyclooctyne linkage and DOTA moiety. This reagent allows for efficient labeling with radioactive zirconium-89, enabling its use as a radionuclide-labeled drug conjugate (RDC). BCN-DOTA-GA is suitable for targeted applications in molecular imaging and radiotherapy, facilitating precise interactions with specific biomolecules, cells, or tissues in various research settings. -
Fluorochrome Dye
Coumarin-PEG3-TCO is a fluorochrome dye that incorporates three PEG units to enhance solubility and stability. Its TCO group facilitates an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-bearing molecules, making it ideal for bioorthogonal labeling applications. This reagent is particularly useful in fluorescence microscopy and tracking cellular processes in live cells. -
Fluorochrome Dye
Coumarin-PEG2-TCO is a fluorescent dye that features a coumarin backbone modified with two PEG units. It utilizes a trans-cyclooctene (TCO) group to engage in an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing compounds. This compound is valuable in biological imaging applications and has potential uses in the development of targeted fluorescent probes for live-cell imaging and other bioconjugation strategies. -
Protein Label
diSulfo-Cy3 alkyne is a water-soluble dye that functions as a Click Chemistry reagent featuring an alkyne group. With absorption and emission characteristics comparable to those of the Cy3 fluorophore, it is suitable for precise labeling of proteins and other biological structures in aqueous environments. This compound is valuable for applications in fluorescence microscopy and bioconjugation studies, enhancing visualization and tracking of target biomolecules in diverse biological research. -
Dye
Sulfo-Cy5-TCO is a water-soluble fluorescent dye that incorporates a trans-cyclooctene (TCO) moiety, facilitating rapid and efficient click chemistry reactions with tetrazines and methyltetrazines. This reagent is designed for use in bioconjugation applications, offering high reactivity and speed that enhances labeling efficiency in various biological experiments. Its unique properties make Sulfo-Cy5-TCO valuable for researchers in fields such as cellular imaging, biomolecule tracking, and targeted drug delivery. -
Azide-Labelled Probe
Cy5 DBCO chloride is a DBCO-based probe designed for applications involving azide-labeled biomolecules. It facilitates copper-free "Click Chemistry" through strain-promoted alkyne-azide cycloaddition (SPAAC), enabling efficient imaging of azide-modified targets. This reagent is particularly valuable for studies involving bioorthogonal labeling and tracking of biomolecules in various research applications, including cellular visualization and bioimaging. -
Alkyne Modified BODIPY TMR-X
BODIPY TMR-X alkyne is an alkyne-modified fluorescent dye that exhibits strong orange fluorescence. It is designed to react with azides through the copper-catalyzed click reaction, enabling specific labeling and tracking in biological systems. With its stable properties across various pH conditions, BODIPY TMR-X alkyne is suitable for a range of applications in live-cell imaging, chemical biology, and other research requiring fluorescent tagging and detection. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
Dye
Dde Biotin-PEG4-TAMRA-PEG4 Alkyne is a dye derivative of TAMRA designed for fluorescent applications, featuring a cleavable biotin moiety. This compound contains alkyne groups that facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its use in a variety of conjugation strategies. It is ideal for research applications involving biomolecular labeling and tracking in cellular and molecular studies. -
Dye
TAMRA-PEG4-methyltetrazine is a fluorescent dye derivative that features a tetrazine moiety for selective labeling applications. The presence of four polyethylene glycol (PEG) units enhances solubility and stability. This compound is designed to undergo inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners, making it suitable for bioconjugation and imaging studies in chemical biology research. -
Dye
TAMRA-PEG4-Alkyne is a fluorescent dye derivative of TAMRA that incorporates four PEG units, enhancing its solubility and biocompatibility. This compound features alkyne functional groups, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. Its unique properties make it valuable for various biological applications, including the labeling of biomolecules and the study of cellular processes through fluorescence imaging. -
Fluorescent Dye
TAMRA DBCO, 5-isomer is a fluorescent dye derivative of tetramethylrhodamine (TMR) featuring a dibenzocyclooctyne (DBCO) moiety. It enables rapid and efficient labeling of azide-containing biomolecules through a sterically promoted azide-alkyne cycloaddition (SPAAC) reaction, eliminating the need for copper catalysts. This compound is suitable for a wide range of applications, including the labeling of proteins, peptides, and nucleic acids, facilitating advanced studies in biochemistry and cellular imaging. -
Fluorescent Dye
OG 488 alkyne is a highly sensitive green-fluorescent dye designed for imaging azide-labeled biomolecules. It participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) to create a stable triazole linkage. This reagent is valuable for visualizing biomolecular interactions and dynamics, making it suitable for various applications in cellular imaging and bioconjugation studies. -
Fluorescent Dye
BP Fluor 488 TCO is a fluorescent dye that participates in the inverse-electron demand Diels-Alder cycloaddition reaction, reacting rapidly and selectively with tetrazines to form stable covalent linkages. This biocompatible reaction occurs without the need for copper catalysts or elevated temperatures, exhibiting an exceptionally high reaction rate constant (k > 800 M-1 s-1). BP Fluor 488 TCO is ideal for applications in bioorthogonal labeling, visualization, and tracking of biomolecules in live cells and various biological studies. -
Fluorescent Dye
ROX alkyne, 6-isomer is an alkyne derivative of the red-emitting fluorescent dye ROX (Rhodamine X, Rhodamine 101), known for its high quantum yield. This compound is particularly useful for fluorescent labeling of azide-containing biomolecules through copper-catalyzed click chemistry. Its applications include quantitative PCR and microscopy, making it an essential reagent for advanced imaging and detection in biochemical research. -
Fluorescent Dye
Cy7 alkyne chloride is a fluorescent dye derivative of Cyanine 7 (Cy7) featuring an alkyne functional group, with an excitation/emission wavelength of 740/770 nm. This reagent can undergo click chemistry reactions with azide-containing molecules, enabling the formation of stable covalent bonds. It is widely utilized in fluorescence imaging, bioconjugation applications, and cellular labeling studies, making it a valuable tool for researchers in bioorthogonal chemistry and related fields. -
click chemistry
FAM alkyne, 6-isomer is a click chemistry reagent designed for specific applications in 1,3-dipolar cycloaddition reactions with azido-labeled compounds. It facilitates the efficient formation of stably linked conjugates, making it a vital tool for bioconjugation studies and labeling in biological research. This compound is suitable for various applications, including imaging, drug delivery, and the development of biosensors. -
Azide Reaction Probe
Cyanine5 DBCO hexafluorophosphate is an azide-reactive probe designed for copper-free "click" reactions, enabling the selective imaging of azide-labeled biomolecules. This near-infrared fluorescent dye exhibits low toxicity to cells, making it suitable for both in vitro and in vivo applications without compromising the physiological functions of non-target cells. Its optimal excitation and emission wavelengths (Ex=635 nm, Em=650-700 nm) facilitate efficient cellular labeling and tracking, providing valuable insights in biological research. -
ADC Linker
DBCO-PEG3-TCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), featuring a 3-unit polyethylene glycol (PEG) spacer. This reagent facilitates click chemistry through its dibenzocyclooctyne (DBCO) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized compounds. Additionally, the TCO group supports inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules, making DBCO-PEG3-TCO a versatile tool for advancing ADC development in therapeutic research. -
Alkyne-conjugated Benzylguanine
Alkyne-SNAP is an alkyne-conjugated benzylguanine that serves as a reactive probe for SNAP-tag fusion proteins. The benzylguanine component enables irreversible and covalent labeling, facilitating the study of protein dynamics and interactions. This reagent is particularly valuable for applications involving click chemistry, allowing the introduction of further functional groups for bioconjugation and subsequent analyses in various biological research contexts. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NH-Boc is a versatile PROTAC linker featuring a cleavable structure designed for the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound utilizes a DBCO moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its PEG4 spacer enhances solubility and stability, making it suitable for various biological applications in drug development and therapeutic research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-amine is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of payloads such as MMAE to antibodies, enhancing targeted delivery to cancer cells. It has demonstrated compelling biological activities, with EC50 values of 280 nM and 22 nM for DBCO-VCpAB MMAE and DBCO-TRX MMAE, respectively, in SKBR3 cells, making it a valuable tool for researchers investigating targeted therapies. -
ADC Linker
BCN-exo-PEG3-maleimide is an ADC linker featuring three PEG units and a bidentate macrocyclic ligand, BCN. It facilitates the formation of stable triazole structures through click chemistry with azide-containing molecules, eliminating the need for catalysts. The maleimide moiety is designed to degrade in aqueous conditions, making it suitable for various drug delivery applications and enhancing the efficacy of antibody-drug conjugates (ADCs) in targeted therapy research. -
PROTAC Linkers
DBCO-N-bis(PEG4-NHS ester) is a bifunctional polyethylene glycol (PEG) linker featuring two NHS ester groups and a dibenzocyclooctyne (DBCO) moiety. This reagent facilitates protein modification and labeling, enhancing bioconjugation applications. As a click chemistry tool, DBCO-N-bis(PEG4-NHS ester) enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable for constructing PROTAC molecules and other bioorthogonal conjugates in various biochemical research settings. -
ADC Linker
bis-PEG2-endo-BCN is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a cyclooctyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling precise conjugation. Its implementation in ADC development enhances targeted delivery of therapeutics, making it valuable for research applications in oncology and drug development. -
Click Chemical Agent
DBCO-PEG24-acid is a click chemistry reagent that incorporates a dibenzocyclooctyne (DBCO) group linked to a hydrophilic polyethylene glycol (PEG) chain. This compound facilitates copper-free click reactions, leveraging the high energy associated with the DBCO moiety for efficient bioconjugation. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amines in the presence of coupling agents such as EDC or HATU. It is a valuable tool in bioconjugation studies and the development of drug delivery systems. -
ADC linker
DBCO-NHS Ester 3 is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. DBCO-NHS Ester 3 is utilized in various applications involving targeted drug delivery and bioconjugation strategies in chemical biology and therapeutic development. -
ADC Linker
Gly-Gly-Gly-PEG4-methyltetrazine is a cleavable polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). It features a tetrazine moiety that facilitates rapid and selective conjugation through an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives. This compound enhances the stability and efficacy of ADCs, making it valuable for targeted delivery of therapeutics in cancer research and other applications in bioconjugation. -
Click Chemistry Intermediate
DBCO-C3-Acid is a versatile Click Chemistry intermediate that serves as a key component in the development of antibody-drug conjugate (ADC) linkers. Its chemical structure facilitates efficient conjugation processes, enabling precise attachment of cytotoxic agents to antibodies. This reagent is essential for advancing research in targeted cancer therapeutics and improving drug delivery systems. -
ADC Linker
Aminooxy-PEG2-BCN is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This reagent features a BCN (cyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique structure enables efficient conjugation in the development of targeted therapeutics, enhancing both delivery and efficacy of payloads in cancer research and other biomedical applications. -
ADC Linker
Mal-bis-PEG3-DBCO is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, functioning through the efficient coupling of DBCO and azide moieties. This reagent incorporates a 3-unit polyethylene glycol (PEG) chain, enhancing solubility and biocompatibility. Its mechanism relies on strain-promoted alkyne-azide cycloaddition (SPAAC), making it ideal for precise conjugation applications in targeted drug delivery and cancer therapeutics research. -
PROTAC Linker
PC Alkyne-PEG4-NHS ester is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). Functioning as a PROTAC linker, this reagent features an alkyne group and participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Its unique structure enhances the specificity and efficiency of conjugating azide-containing molecules, making it valuable for various chemical biology applications, including targeted drug delivery and proteolysis targeting chimera (PROTAC) development. -
PROTAC Linker
TCO-PEG4-DBCO is a versatile PROTAC linker known for its ability to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds, while the TCO component allows for inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine derivatives. TCO-PEG4-DBCO finds applications in the development of antibody-drug conjugates (ADCs), enhancing the precision and efficacy of targeted therapeutics. Its unique chemical properties make it a valuable tool for researchers in chemical biology and drug development. -
ADC Linker
Mal-PEG2-bis-PEG3-BCN is a cleavable linker designed for use in antibody-drug conjugates (ADCs). Featuring a BCN moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enhancing conjugation efficiency. This reagent is ideal for the development of targeted therapies in cancer research and other applications requiring precise drug delivery mechanisms. -
ADC Linker
TCO-SS-amine is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring a TCO group, this reagent facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules. Its selective and efficient coupling capabilities make TCO-SS-amine a valuable tool in ADC development, enabling targeted delivery of therapeutic agents in cancer research and drug discovery applications. -
Click Chemistry Reagent
ICG-alkyne is a click chemistry reagent characterized by the presence of an alkyne functional group, enabling efficient conjugation through the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. This reagent facilitates the labeling and visualization of biomolecules, making it a valuable tool in bioconjugation and imaging applications. Its utility spans various research fields, including chemical biology, biochemistry, and nanotechnology, where precise molecular interactions are essential for experimental outcomes. -
ADC Linker
Mal-Sulfo-DBCO is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. Featuring a DBCO moiety, it facilitates the efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with azide-containing compounds. This property makes Mal-Sulfo-DBCO valuable for precise conjugation in targeted drug delivery applications, enhancing therapeutic efficacy while minimizing off-target effects. -
Azide Compound
Hydroxy-PEG3-DBCO is a versatile click chemistry reagent featuring a DBCO moiety and a terminal hydroxyl group. This PEG-based linker enhances solubility for labeled molecules while enabling efficient reactions with various functional groups. DBCO facilitates copper-free click chemistry, making it suitable for a wide range of bioconjugation applications in chemical and biochemical research. Designed for use in laboratory research, this reagent provides a reliable tool for developing complex biological systems and materials. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NHS ester is a versatile linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG/alkyl/ether-based compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its cleavable nature enhances the functionality and targeting capabilities of therapeutic agents, making it essential for researchers involved in drug development and bioconjugation applications. -
ADC Linker
DBCO-PEG1-OH is an ADC linker designed for effective conjugation in antibody-drug conjugate (ADC) applications. This compound facilitates the synthesis of ADCs by providing a stable and efficient link between monoclonal antibodies and therapeutic agents. Its utility in ADC development supports research in targeted cancer therapies and drug delivery systems. -
ADC Linker
GDP-L-Fuc-PEG4-BCN is a cleavable linker designed for use in antibody-drug conjugates (ADCs). This linker facilitates the efficient conjugation of antibodies with cytotoxic drugs, enhancing targeted delivery to tumor cells. Its incorporation allows for controlled release of therapeutic agents upon internalization, making it suitable for cancer research and the development of innovative ADC therapeutics. -
Click Chemistry Reagent
Alkyne-PEG2-iodide is a click chemistry reagent featuring a terminal alkyne and an alkyl iodide moiety. This compound serves as a versatile tool for biomolecular labeling and conjugation due to its ability to undergo efficient cycloaddition reactions. It is particularly useful in various applications, including bioconjugation, proteomics, and the development of novel therapeutics. -
ADC Linker
PC Biotin-PEG3-alkyne is a cleavable antibody-drug conjugate (ADC) linker featuring a three-unit polyethylene glycol (PEG) chain. This linker incorporates an alkyne group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. It is designed for the synthesis of ADCs, facilitating targeted drug delivery in various biological research applications. -
PROTAC linker
Boc-gly-PEG3-endo-BCN is a cleavable PEG-based linker designed for targeted protein degradation applications through PROTAC technology. Its biocompatible structure facilitates the synthesis of antibody-drug conjugates (ADCs) by serving as a versatile linker. The presence of a bicyclo[6.1.0]nonyne (BCN) group allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, making it a valuable reagent for click chemistry in biological research. -
ADC Linker
DBCO-PEG3-C1-acid is an efficient ADC linker designed to facilitate strain-promoted azide-alkyne click reactions. This reagent serves as a powerful tool in the development of antibody-drug conjugates, enhancing target specificity and therapeutic efficacy. Its biocompatible PEG spacer provides solubility and flexibility, making it ideal for conjugating various cytotoxic agents for targeted cancer therapy applications. -
Azide Compound
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent featuring an azide group, designed for selective labeling of primary amine-containing biomolecules. The compound incorporates a PEG linker and a sulfo-NHS ester moiety, enhancing solubility in aqueous buffers, facilitating its utility in bioconjugation applications. It enables the covalent attachment of TCO moieties to proteins, antibodies, and other macromolecules, while participating in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing partners. This reagent is suitable for various research applications, including protein labeling and targeted drug delivery studies. -
ADC Linker
DBCO-PEG4-Val-Ala-PAB is a cleavable ADC linker that effectively targets Cathepsin B for linker cleavage. The incorporation of Val-Ala linkers facilitates the controlled release of therapeutic agents, enhancing the efficacy of antibody-drug conjugates (ADCs). The DBCO moiety enables efficient Click Chemistry reactions, while the PEG spacer enhances the aqueous solubility of the compound, making it suitable for various biochemical applications.
