DBCO-PEG3-TCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), featuring a 3-unit polyethylene glycol (PEG) spacer. This reagent facilitates click chemistry through its dibenzocyclooctyne (DBCO) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized compounds. Additionally, the TCO group supports inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules, making DBCO-PEG3-TCO a versatile tool for advancing ADC development in therapeutic research.
DBCO-PEG3-TCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), featuring a 3-unit polyethylene glycol (PEG) spacer. This reagent facilitates click chemistry through its dibenzocyclooctyne (DBCO) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized compounds. Additionally, the TCO group supports inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules, making DBCO-PEG3-TCO a versatile tool for advancing ADC development in therapeutic research.
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