Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and flexibility, thereby improving the efficacy of targeted protein degradation. It is suitable for various research applications, particularly in the study of targeted therapies and cellular protein regulation. -
PROTAC Linker
Sulfo DBCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. This compound facilitates targeted degradation of proteins by connecting E3 ubiquitin ligases to specific proteins of interest. Its application in PROTAC development enhances selectivity and efficacy in degradation pathways, supporting research in targeted protein modulation and therapeutic interventions. -
PROTAC Linker
endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. This compound features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It plays a crucial role in the development of targeted protein degradation strategies and is suitable for applications in drug discovery and chemical biology research. -
PROTAC Linker
Biotin-PEG4-amide-Alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique properties facilitate targeted protein degradation research, making it a valuable tool for bioconjugation and drug discovery applications. -
PROTAC Linker
DBCO-PEG4-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs. It features a dibenzocyclooctyne (DBCO) moiety, enabling reaction via strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for the development of targeted protein degradation strategies, facilitating precise modular assembly in therapeutic research applications. -
PROTAC Linker
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. Featuring a bicyclo[6.1.0]nonyne (BCN) group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its robust click chemistry properties make it suitable for applications in protein degradation research and therapeutic development. -
PROTAC Linkers
TCO-PEG8-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted degradation of proteins thought unsuitable for classical small-molecule approaches. It is a valuable tool for researchers investigating protein regulation, cellular signaling pathways, and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker featuring an alkyne group, facilitating the synthesis of PROTACs. This compound serves as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the design of bifunctional molecules allows for enhanced targeted degradation of proteins, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linker
DBCO-PEG4-Desthiobiotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a DBCO moiety that facilitates efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for developing targeted protein degradation tools, enabling researchers to investigate protein function and cellular pathways through controlled protein turnover. -
PROTAC Linker
Tetrazine-Ph-NHS ester is a key PROTAC linker utilized in the synthesis of protein-targeting chimeras. This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO)-modified entities. Its application is vital for the development of targeted protein degradation strategies in chemical biology research, enabling the selective modulation of protein levels within cells. -
PROTAC Linker
TCO-amine (hydrochloride) is an alkyl chain-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains a TCO moiety, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. TCO-amine (hydrochloride) serves as a crucial tool in targeted protein degradation research, facilitating the development of novel therapeutic agents. -
PROTAC Linker
exo BCN-O-PNB is a versatile alkyl/ether-based PROTAC linker designed for the synthesis of PROTAC molecules. As a click chemistry reagent, it features a BCN group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This mechanism facilitates the creation of stable and efficient bifunctional molecules, aiding in targeted protein degradation research applications. -
PROTAC Linkers
Oleic-DBCO is a versatile PROTAC linker featuring an alkyl chain structure. It serves as a click chemistry reagent, incorporating a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property makes Oleic-DBCO valuable for the synthesis of targeted protein degradation compounds in chemical biology research, enabling the study of protein function and drug development. -
PROTAC Linkers
DBCO-PEG1-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It facilitates the development of targeted protein degradation strategies, making it valuable in research applications focused on therapeutic interventions targeting specific proteins. -
PROTAC Linker
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties make it suitable for applications in cellular proteomic studies and drug discovery, highlighting its utility in targeted protein degradation research. -
PROTAC Linkers
N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based linker designed for the synthesis of PROTACs. This reagent features a DBCO group that allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances labeling and purification processes, making it valuable in target protein degradation studies and other biochemical applications. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linkers
Pip-alkyne-Ph-COOCH3 is a versatile PROTAC linker designed for the synthesis of PROTAC ARD-266. This compound features an alkyne group, facilitating its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc). It plays a critical role in forming stable linkages between target proteins and E3 ligases, supporting research in targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Carboxyrhodamine 110-PEG4-alkyne is a PEG (polyethylene glycol)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the effective conjugation of target proteins to an E3 ligase for selective degradation. This compound is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies. Its properties enable precise modulation of biological activity in various cellular contexts. -
PROTAC Linkers
Boc-Pip-alkyne-Ph-COOH is a PROTAC linker designed for use in the synthesis of targeted protein degraders. It facilitates the development of PROTACs, including ARD-266, which effectively promotes degradation of the androgen receptor in AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, exhibiting DC50 values of 0.2-1 nM. This compound features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it essential for click chemistry applications in chemical biology research. -
PROTAC Linker
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based linker specifically designed for PROTAC synthesis. This compound features a TCO moiety that facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules, enabling effective targeting and degradation of proteins. It is widely used in chemical biology to create novel therapeutics and to study protein interactions and degradation pathways. -
PROTAC Linker
Cbz-NH-PEG-alkyne is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the selective degradation of target proteins through the recruitment of E3 ubiquitin ligases, enabling targeted therapeutic applications in cancer and other diseases. Its unique alkyne group allows for efficient conjugation and modification, making it an essential reagent for chemical biology researchers investigating targeted protein degradation. -
PROTAC Linker
Alkyne-PEG4-I is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its alkyne functionality facilitates the formation of stable covalent bonds, enabling efficient engagement of target proteins for degradation. This linker is integral for researchers investigating targeted protein degradation pathways and developing novel therapeutic agents. -
PROTAC Linker
Azide-PEG12-Tos is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Azide-PEG12-Tos is valuable for researchers working on targeted protein degradation and other bioconjugation applications. -
PROTAC Linker
Ts-PEG3-O-C-alkynes-TBS is a linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to the ubiquitin-proteasome system, enabling selective protein degradation. It serves as a pivotal component in PROTAC development, enhancing the efficacy of targeted protein modulation for various research applications, including cancer biology and therapeutic discovery. -
PROTAC Linker
DBCO-PEG5-GGG-NH2 is a versatile PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound efficiently connects target proteins with E3 ligases, enabling the modulation of protein degradation pathways. Its application in synthetic biology allows researchers to explore targeted protein degradation strategies for therapeutic interventions. -
PROTAC Linker
m-PEG5-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of protein ligands to E3 ligases, enhancing the targeted degradation of specific proteins within the cell. m-PEG5-Hydrazide is essential for researchers aiming to develop novel therapeutic strategies through targeted protein modulation and degradation. -
PROTAC Linker
TCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems. -
PROTAC Linker
1-Isothiocyanato-PEG3-azide is a versatile PEG-based PROTAC linker that facilitates the synthesis of proteolysis targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with entities possessing DBCO or BCN groups. Its utility in conjugation chemistry supports various applications in chemical biology and drug development. -
PROTAC Linker
TBS-PEG4-O-alkyne is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of protein ligands to an E3 ubiquitin ligase, allowing for targeted degradation of specific proteins. Its key biological activity lies in enhancing the solubility and bioavailability of PROTACs, making it an essential component in targeted protein degradation research. TBS-PEG4-O-alkyne is widely utilized in pharmacological studies and drug discovery applications. -
PROTAC Linker
(S,R,S)-Ahpc-PEG6-azide is a click chemistry PROTAC linker that integrates an E3 ligase ligand and a PEG6 arm, facilitating the advancement of PROTAC research and discovery. The hydrophilic PEG spacer enhances solubility in aqueous environments, making it suitable for various biological applications. The presence of the azide functionality allows for efficient click chemistry reactions with alkyne, DBCO, or BCN molecules, thereby enabling versatile conjugation strategies in drug development. -
PROTAC linker
endo-BCN-PEG3-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by enabling targeted protein degradation. This compound features a bicyclononyne (BCN) group, which allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its applications extend to the development of advanced therapeutic modalities in chemical biology and drug discovery. -
PROTAC Linker
m-PEG6-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase ligands to target proteins by providing a flexible and hydrophilic spacer. Its unique structure enhances the solubility and stability of PROTACs, making it an essential tool for studies focused on targeted protein degradation and drug discovery applications. -
PROTAC Linker
H2N-PEG4-Hydrazide is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing target degradation through the ubiquitin-proteasome system. H2N-PEG4-Hydrazide is essential for researchers exploring targeted protein degradation approaches in drug discovery and development. -
PROTAC Linkers
DBCO-PEG5-DBCO is a PEG-based linker specifically designed for synthesizing PROTACs. Featuring a dibenzocyclooctyne (DBCO) moiety, this reagent enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its versatility makes it an invaluable tool in the development of targeted protein degradation strategies, facilitating research into novel therapeutic approaches in various biological systems. -
PROTAC Linker
Sulfo DBCO-amine is a versatile PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for efficient and selective conjugation. Its application in chemical biology is crucial for developing targeted protein degraders, thereby advancing research in protein modulation and therapeutic intervention. -
PROTAC linker
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based linker designed for PROTAC synthesis, functioning primarily through click chemistry. Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent enhances the development of targeted protein degradation strategies, proving valuable in various biochemical applications and studies aimed at modulating protein levels within cellular systems. -
PROTAC Linkers
TCO-PEG9-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of targeting moieties and E3 ligase recruiting units, enabling the effective degradation of selected proteins. This linker is particularly valuable in chemical biology and drug discovery research, where targeted protein degradation mechanisms are being explored for therapeutic development. -
PROTAC Linker
DBCO-PEG4-alcohol is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. Featuring a DBCO group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in the development of targeted protein degradation strategies underscores its significance in chemical biology and therapeutic research. -
PROTAC Linkers
DBCO-PEG12-Maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, enabling efficient and selective conjugation. This chemical reagent is valuable in targeted protein degradation studies and the development of novel therapeutic strategies. -
PROTAC Linker
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation and offers significant potential for therapeutic research in various diseases. -
PROTAC Linkers
5-endo-BCN-pentanoic acid is a versatile PROTAC linker featuring a BCN group, which enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This alkyl chain-based linker facilitates the synthesis of PROTACs, enhancing targeted protein degradation and enabling innovative therapeutic strategies. Its applications span various biological research areas, allowing for precise manipulation of protein interactions to study cellular processes. -
PROTAC linker
DSPE-PEG4-DBCO is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs. This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. As a versatile click chemistry reagent, DSPE-PEG4-DBCO facilitates the construction of bifunctional probes for targeted protein degradation studies and other applications in chemical biology. -
PROTAC Linkers
DBCO-NHCO-PEG6-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the conjugation of biotin for enhanced target protein degradation. This reagent is ideal for applications in chemical biology and drug discovery, particularly in the development of advanced therapeutic modalities. -
PROTAC Linker
PC DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs, functioning as a critical component in targeted protein degradation. This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized molecules. It serves as a valuable tool in chemical biology for developing novel therapeutic strategies by enabling the creation of bifunctional compounds that can modulate protein interactions. -
PROTAC Linkers
DBCO-NHCO-PEG2-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO (dibenzocyclooctyne) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted degradation of specific proteins, enhancing research in pharmacology and therapeutic discovery. -
PROTAC Linkers
TCO-PEG6-amine is a PEG-derived linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules to selectively degrade target proteins via the ubiquitin-proteasome system. Its unique structure enables effective conjugation with other moieties, contributing to research applications in targeted protein degradation and molecular biochemistry. -
PROTAC Linker
Diazo Biotin-PEG3-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its applications extend to the development of targeted protein degradation methods, facilitating the exploration of protein interactions and degradation pathways in chemical biology research. -
PROTAC Linker
DBCO-PEG3-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features a DBCO group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its application in the development of bifunctional degraders positions DBCO-PEG3-amine as a valuable tool in chemical biology research, particularly for targeted protein degradation studies. -
PROTAC Linkers
DNP-PEG4-DBCO is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound serves as a click chemistry reagent, featuring a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for developing targeted protein degradation strategies in various biological research applications.
