Click Chemistry

Mal-PEG4-bis-PEG3-DBCO is a cleavable linker designed for use in antibody-drug conjugates (ADCs), facilitating targeted delivery of therapeutics. This reagent features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for efficient conjugation. Its PEGylated structure enhances solubility and provides stability in biological applications, making it suitable for ADC development and related research endeavors.

Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent that features an azide group, facilitating bioorthogonal reactions. It contains a methyltetrazine moiety and two carboxylic acid groups, enabling stable covalent bonding with TCO-containing compounds through inverse-electron demand Diels-Alder cycloaddition. This reaction occurs rapidly and with high selectivity, avoiding the need for copper catalysis or elevated temperatures. Additionally, the PEG linker enhances water solubility, while the terminal carboxylic acid can react with primary amines in the presence of coupling agents to form stable amide bonds, making it suitable for various research applications in chemical biology.

DBCO-PEG3 acetic-EVCit-PAB is a cleavable ADC linker that features a three-unit polyethylene glycol (PEG) chain. This compound facilitates the construction of antibody-drug conjugates (ADCs) by employing click chemistry through its dibenzocyclooctyne (DBCO) moiety, which engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG3 acetic-EVCit-PAB is integral in enhancing the specificity and efficacy of therapeutic agents in targeted cancer treatments, making it a valuable tool for bioconjugation research.

DBCO-PEG4-alkyne is a non-cleavable linker designed for antibody-drug conjugates (ADCs), featuring a 4-unit polyethylene glycol (PEG) chain. This compound serves as a versatile click chemistry reagent, incorporating an alkyne functional group that enables the efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in ADC synthesis facilitates the stable conjugation of therapeutic agents, enhancing the efficacy and selectivity of targeted cancer treatments.

Bromoacetamide-PEG4-DBCO is an efficient ADC linker that facilitates the synthesis of antibody-drug conjugates. This compound features a bromoacetamide moiety for selective labeling and a DBCO group for click chemistry applications. It is ideal for enhancing the therapeutic efficacy of targeted cancer treatments by enabling stable conjugation to antibodies. This linker is suitable for a variety of research applications focused on drug delivery systems and cancer therapeutics.

BCN-PEG4-HyNic is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, featuring a four-unit polyethylene glycol (PEG) spacer. Its primary mechanism involves click chemistry, specifically through the strain-promoted alkyne-azide cycloaddition (SPAAC) reaction, which facilitates the conjugation of azide-containing biomolecules. This reagent is ideal for researchers developing targeted therapeutics, enabling enhanced delivery and reduced systemic toxicity of cytotoxic drugs in cancer therapy.

beta-Glc-TEG-Alkyne is an alkyne-containing click chemistry reagent that facilitates the formation of covalent bonds through the copper-catalyzed azide-alkyne cycloaddition (CuAAC) mechanism. This compound exhibits significant utility in biochemical research for labeling biomolecules, studying cellular interactions, and developing bioconjugates. Its unique properties make it a valuable tool for applications in chemical biology and biopharmaceutical development.

Biotin-PEG(4)-SS-Alkyne is an alkyne-containing click chemistry reagent that facilitates bioconjugation via a bioorthogonal reaction. This compound features a biotin moiety, enabling the labeling and detection of biomolecules in various biochemical assays. Its primary applications include studying protein interactions, cellular imaging, and the development of targeted therapies, providing a valuable tool in biochemical research.

Diazido-methyltetrazine tri-arm is a versatile ADC linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective conjugation of cytotoxic agents to antibodies, enhancing therapeutic efficacy while minimizing off-target effects. Its structural features allow for efficient formation of stable linkages, making it suitable for various applications in ADC development and cancer research.

DBCO-PEG2-C2-acid is an efficient ADC linker that facilitates the synthesis of Antibody-Drug Conjugates (ADCs). This compound utilizes the DBCO (dibenzocyclooctyne) chemistry for site-specific conjugation, enhancing the stability and efficacy of the resulting ADCs. It is essential for researchers focused on developing targeted therapies in oncology and other therapeutic areas, allowing for improved drug delivery and minimized off-target effects.

TCO-GK-PEG4-NHS ester is an ADC linker that facilitates the synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d, which exhibits high affinity and immunoreactivity for the HER2 target. This compound features a TCO group that participates in inverse electron demand Diels-Alder (iEDDA) click chemistry reactions with tetrazine-containing molecules, allowing for precise bioconjugation applications in targeted therapies. It is suitable for research involving antibody-drug conjugates and the development of advanced molecular imaging techniques.

DBCO-S-S-acid is a cleavable linker designed for the construction of antibody-drug conjugates (ADCs). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for selective and efficient conjugation. This reagent is essential in bioconjugation strategies aimed at enhancing targeted therapeutic delivery in cancer research and other therapeutic applications.

Me-Tetrazine-Me-Ph-amide-Lys(Boc)-Lys-N3 is an innovative ADC linker that facilitates the construction of antibody-drug conjugates (ADCs). This reagent provides a robust mechanism for site-specific conjugation, enhancing the therapeutic efficacy of ADCs. It is particularly useful in research applications focused on targeted cancer therapies and precision medicine.

BCN-exo-PEG2-maleimide is an ADC linker characterized by the presence of two PEG units and a bidentate macrocyclic ligand, BCN. This compound facilitates the formation of stable triazole linkages through click chemistry by reacting with azide-containing molecules, and operates without the need for catalysts. Its maleimide group is hydrolytically labile in aqueous environments, making it suitable for applications in drug delivery and bioconjugation studies.

BCN-HS-PEG2-bis(PNP) is a p-nitrophenyl-containing linker intermediate designed for use in antibody-drug conjugate (ADC) applications. It facilitates the conjugation of cytotoxins with peptide linkers, thereby enabling the formation of stable Drug-Linker Conjugates. BCN-HS-PEG2-bis(PNP) has demonstrated efficacy in coupling with vc-PABC-MMAE, making it a valuable reagent in ADC development for targeted cancer therapies.

DBCO-NHCO-PEG4-acid is a PEG-based linker designed for application in antibody-drug conjugates (ADCs) and PROTAC synthesis. This linker features a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC), facilitating selective conjugation with azide-containing molecules. Its chemical properties make it ideal for developing targeted therapeutics that can modulate protein levels in biological research, enhancing experimental outcomes in drug discovery and development.

Sulfo DBCO-PEG3-acid is a click chemistry reagent featuring an azide group that facilitates copper-free Click Chemistry reactions through its DBCO moiety. The compound's hydrophilic PEG linker and sulfonate group enhance solubility in aqueous environments, making it suitable for biological applications. The terminal carboxylic acid reacts with primary amine groups in the presence of coupling agents such as EDC or HATU, generating stable amide bonds for bioconjugation studies. This reagent is intended for research purposes only.

Endo-BCN-Fmoc-L-Lysine is a specialized linker featuring the bidentate macrocyclic ligand endo-BCN, designed for use in antibody-drug conjugate (ADC) applications. This compound facilitates the synthesis of macrocyclic complexes and participates in click chemistry, where it can react with azide-containing molecules to form stable triazoles without the need for catalysts. Its properties make it particularly valuable in bioconjugation and therapeutic development research.

Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent featuring a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds through an Inverse-Electron-Demand Diels-Alder reaction with TCO-containing substrates, eliminating the need for Cu-catalysis or elevated temperatures. It is primarily utilized in bioconjugation applications, enhancing the specificity and efficiency of labeling procedures in biological research.

Alkyne-SS-COOH is an alkyne-functionalized reagent designed for click chemistry applications. This compound facilitates the formation of covalent bonds in a variety of biochemical contexts, enabling applications such as protein labeling, bioconjugation, and cellular imaging. Its versatile reactivity makes it a valuable tool for researchers in chemical biology and materials science.

Alkyne-Val-Cit-PAB-OH is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates the selective release of drug payloads within target cells, enhancing therapeutic efficacy while minimizing off-target effects. Its hydrophilic properties and favorable stability make it suitable for various ADC applications, including cancer therapy and targeted drug delivery research.

Sulfo DBCO-TFP Ester is a water-soluble click chemistry reagent that features a sulfo group. This compound facilitates the efficient and straightforward conjugation of sulfo-DBCO moieties to amine-containing biomolecules. Its applications include labeling, drug delivery, and the development of bioconjugates in various biochemical and biomedical research fields.

BCN-exo-PEG2-NH2 is an ADC linker featuring two polyethylene glycol (PEG) units. This compound incorporates the hydrophilic bidentate macrocyclic ligand, BCN, facilitating the formation of macrocyclic complexes. In click chemistry applications, BCN efficiently reacts with azide-containing molecules, yielding stable triazoles without the need for catalysts, making it valuable for antibody-drug conjugate (ADC) development and other bioconjugation strategies.

BCN-endo-PEG7-NH2 is a bifunctional ADC linker featuring a 7-unit PEG spacer and the lipophilic macrocyclic ligand endo-BCN. This compound enables efficient conjugation through click chemistry, allowing stable triazole formation with azide-containing molecules without the need for catalysts. BCN-endo-PEG7-NH2 is suitable for applications in antibody-drug conjugate (ADC) development and other bioconjugation techniques, facilitating targeted delivery and enhancing therapeutic efficacy in chemical biology research.

Alkyne-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates stable attachment of cytotoxic agents to antibodies while enabling release in the target tissues or cells via specific enzymatic cleavage. Its properties make it suitable for research applications focused on enhancing the efficacy and selectivity of ADCs in cancer therapy and related studies.

DecarboxyBiotin-Alkyne is a click chemistry reagent featuring an azide group that facilitates bioconjugation reactions. This compound demonstrates high specificity and yield when used for labeling nucleic acids, lipids, and proteins. It is particularly valuable in diverse research applications, including cellular imaging and biomolecular interaction studies, allowing for efficient tagging and tracking of biomolecules.

Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne is a conjugated compound featuring Zanamivir, a potent neuraminidase inhibitor. This compound facilitates the study of viral infections through its unique linker structure, enabling enhanced application in biochemical and biophysical assays. Researchers can utilize Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne for exploring therapeutic strategies and mechanisms related to viral pathogenesis.

Alkyne-cRGD is an integrin ligand that facilitates targeted binding to integrin proteins. This compound is valuable in the study of protein degraders and can be utilized in copper-catalyzed azide-alkyne cycloaddition reactions for bioconjugation applications. Its ability to selectively interact with integrins makes it a key tool in cancer research and various therapeutic studies.

DBCO-PEG4-TAMRA is a PEG-conjugated TAMRA dye featuring a dibenzocyclooctyne (DBCO) moiety, facilitating efficient Click Chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for oligonucleotide labeling and is widely utilized in automated DNA sequencing applications. Its bioconjugation capabilities enhance the specificity and sensitivity of various research techniques, making it a valuable tool in molecular biology and biochemical studies.

TAMRA alkyne, 6-isomer serves as a versatile linker that enables the conjugation of TAMRA to various biomolecules. Its unique structure facilitates efficient labeling of proteins and nucleic acids, enhancing fluorescence detection and imaging applications. This reagent is essential for researchers utilizing fluorescence in assays, cellular imaging, and other applications requiring precise biomolecular visualization.

MTDB-Alkyne is an alkyne-functionalized reagent designed for click chemistry applications. It serves as a synthetic precursor for Proximity-Induced Nucleic Acid Degraders (PINAD), facilitating the targeted degradation of SARS-CoV-2 RNA. Its unique mechanism allows for effective RNA manipulation, making it a valuable tool in antiviral research and therapies aimed at combating COVID-19.

TCO-PEG3-Biotin is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, featuring a three-unit polyethylene glycol (PEG) backbone. This compound includes a trans-cyclooctene (TCO) moiety that facilitates click chemistry through an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG3-Biotin is valuable in conjugating biomolecules, enabling targeted drug delivery and enhancing therapeutic efficacy in various biological research applications.

PTAD-PEG4-alkyne is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This 4-unit polyethylene glycol (PEG) linker features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. Its unique properties facilitate the targeted delivery of therapeutic agents, making it a valuable tool in the development of ADCs for research applications in cancer therapeutics and other fields.

Bis-Mal-Lysine-PEG4-DBCO is a dibenzocyclooctyne (DBCO) linker designed for use in alkyne-azide cycloaddition (AOC) applications. This compound facilitates the synthesis of AOC drugs, enabling the targeted inhibition of DMPK gene expression. Its efficient coupling properties make it a valuable tool for research in gene regulation and therapeutic development.

TcO-ABX474 is a potent inhibitor of prostate-specific membrane antigen (PSMA), exhibiting a Kd value of 6.1 nM. It effectively inhibits the growth and metastasis of prostate cancer cells, making it a valuable tool for research in prostate cancer biology. This compound is suitable for studies investigating PSMA-mediated pathways and the development of targeted therapies for prostate cancer.

H-151 Alkyne is a selective inhibitor of STING (Stimulator of Interferon Genes). This compound demonstrates potential for modulating immune responses, making it valuable in the study of autoimmune diseases such as systemic lupus erythematosus and scleroderma, as well as autoinflammatory conditions. Its ability to interfere with STING pathways allows researchers to explore therapeutic strategies targeting these diseases.

Thiobis-β-Galactose-propyne serves as a versatile click chemistry reagent with an alkyne functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Primarily, it acts as a multivalent inhibitor of galectin-3 (Gal-3), a protein implicated in various metabolic processes associated with cancer progression. This compound is suitable for applications in biochemical research focused on galectin-3-related pathways and provides a valuable tool for the development of targeted therapeutic strategies.

diABZI-V/C-DBCO is a potent STING agonist with an EC50 of 1.47 nM. It activates the STING pathway to promote the production of type I interferons, particularly IFN-β, enhancing immune responses. This compound acts as a substrate for cathepsin B, leading to the release of active diABZI-amine through cathepsin B-mediated cleavage. In preclinical studies using an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO has been shown to elevate serum levels of IFN-β and increase the frequency of granzyme B+ CD8+ T cells, making it valuable for research in triple-negative breast cancer.

6-Alkyne-F-araNAD is an irreversible inhibitor of CD38, a critical enzyme involved in the regulation of cyclic ADP-ribose and NAD metabolism. This compound enhances the efficacy of fluorescent probes, such as SR101-F-araNMN, allowing for improved visualization of intracellular CD38 localization. It serves as a valuable tool in studies related to immune signaling and cellular response mechanisms.

Alkyne Cholesterol is a modified lipid featuring a terminal alkyne group, designed for click chemistry applications. This reagent facilitates highly specific conjugation reactions with azide-containing compounds in the presence of copper catalysts. Alkyne Cholesterol is instrumental for studying cellular cholesterol metabolism and localization, enabling detailed insights into lipid biology.

DSPE-PEG2000-TCO is a PEGylated derivative that functions as a coupling partner in click chemistry through a reverse electron-demand Diels-Alder reaction. This compound facilitates the formation of covalent linkages with tetrazine-modified biomolecules, enhancing the stability of lipid nanoparticles (LNPs) while promoting efficient mRNA encapsulation. It plays a critical role in the development of EGFR-targeted and APN-targeted mRNA-loaded LNPs, supporting receptor-mediated endocytosis, effective mRNA delivery, and intestinal epithelial transcytosis in various research applications.

Oleic acid alkyne is an oleic acid analog featuring a terminal acetylene group. This modification enables its use in click chemistry, facilitating chemical ligation reactions. It allows for the hydroxylation of oleic acid by a microsomal cytochrome P-450-dependent system (ω-OAH). Through these reactions, fluorescent or biotin-labeled variants can be synthesized, making it a valuable tool for studying oleic acid metabolism and biological activity in various research applications.

IA-Alkyne is a TRPC channel (TRPC) agonist that facilitates the investigation of respiratory infections through enhanced channel activity. This compound serves as a versatile chemical probe for quantitative profiling of cysteine reactivity, enabling isotopic tagging. Additionally, IA-Alkyne features an alkyne functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry applications in various biological research studies.

DMG-PEG(2k)-DBCO is a clickable PEG lipid featuring a DBCO moiety. This compound is primarily utilized in the formulation of lipid nanoparticles, facilitating effective drug delivery applications. Its biochemical properties enable efficient conjugation processes, making it valuable for various bioconjugation strategies in lipid-based formulations.

DSPE-alkyne is a phospholipid functioning as a click chemistry reagent, characterized by the presence of an alkyne group. This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. DSPE-alkyne is widely utilized in bioconjugation applications, facilitating the formation of stable links between biomolecules for advanced research in drug delivery and molecular imaging.

Arachidonic acid-alkyne is a ω-alkynyl lipid surrogate specifically designed for polyunsaturated fatty acid research. This compound demonstrates low oxidation rates, making it suitable for studies involving the tracking and analysis of polyunsaturated fatty acids in biological systems. Its unique chemical properties facilitate investigations into lipid metabolism and signaling pathways, expanding its utility in various biochemical and pharmacological applications.

Tetrazine-Ph-NHCO-C3-NHS ester serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a Tetrazine group that enables a selective inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules. It is instrumental in developing targeted protein degradation strategies in chemical research, enhancing the precision of therapeutic interventions.

DBCO-PEG3-NHS is a PROTAC linker featuring an alkynyl (DBCO) and N-hydroxysuccinimide (NHS) ester group, facilitating the chemical modification of proteins and antibodies. This reagent is instrumental in the synthesis of PROTACs, enhancing targeted protein degradation applications, as well as contributing to drug delivery systems and the development of biosensors and diagnostic assays. It allows for precise conjugation chemistry, enabling innovative research in therapeutic development and biomolecular interactions.

Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecular constructs. This compound features a tetrazine moiety that facilitates click chemistry via an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO) derivatives. Its biological activity allows for the selective recruitment of E3 ligases, making it a valuable tool for researchers studying protein regulation and degradation pathways. This reagent is essential for the development of innovative therapies utilizing PROTAC technology.

endo-BCN-PEG2-C2-NHS ester functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This linker is designed to enhance target specificity and efficacy in targeted protein degradation research. Its properties make it suitable for studies focusing on cellular signaling, protein homeostasis, and therapeutic interventions in various diseases.