Catalog No.
Product Name
Application
Product Information
Citations
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Azide Compound
Sulfo DBCO-PEG3-acid is a click chemistry reagent featuring an azide group that facilitates copper-free Click Chemistry reactions through its DBCO moiety. The compound's hydrophilic PEG linker and sulfonate group enhance solubility in aqueous environments, making it suitable for biological applications. The terminal carboxylic acid reacts with primary amine groups in the presence of coupling agents such as EDC or HATU, generating stable amide bonds for bioconjugation studies. This reagent is intended for research purposes only. -
ADC Linker
Endo-BCN-Fmoc-L-Lysine is a specialized linker featuring the bidentate macrocyclic ligand endo-BCN, designed for use in antibody-drug conjugate (ADC) applications. This compound facilitates the synthesis of macrocyclic complexes and participates in click chemistry, where it can react with azide-containing molecules to form stable triazoles without the need for catalysts. Its properties make it particularly valuable in bioconjugation and therapeutic development research. -
Methyltetrazine Compound
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent featuring a methyltetrazine moiety. This compound facilitates the formation of stable covalent bonds through an Inverse-Electron-Demand Diels-Alder reaction with TCO-containing substrates, eliminating the need for Cu-catalysis or elevated temperatures. It is primarily utilized in bioconjugation applications, enhancing the specificity and efficiency of labeling procedures in biological research. -
Alkyne Compound
Alkyne-SS-COOH is an alkyne-functionalized reagent designed for click chemistry applications. This compound facilitates the formation of covalent bonds in a variety of biochemical contexts, enabling applications such as protein labeling, bioconjugation, and cellular imaging. Its versatile reactivity makes it a valuable tool for researchers in chemical biology and materials science. -
ADC Linker
Alkyne-Val-Cit-PAB-OH is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates the selective release of drug payloads within target cells, enhancing therapeutic efficacy while minimizing off-target effects. Its hydrophilic properties and favorable stability make it suitable for various ADC applications, including cancer therapy and targeted drug delivery research. -
Click Chemistry Reagent
Sulfo DBCO-TFP Ester is a water-soluble click chemistry reagent that features a sulfo group. This compound facilitates the efficient and straightforward conjugation of sulfo-DBCO moieties to amine-containing biomolecules. Its applications include labeling, drug delivery, and the development of bioconjugates in various biochemical and biomedical research fields. -
ADC Linker
BCN-exo-PEG2-NH2 is an ADC linker featuring two polyethylene glycol (PEG) units. This compound incorporates the hydrophilic bidentate macrocyclic ligand, BCN, facilitating the formation of macrocyclic complexes. In click chemistry applications, BCN efficiently reacts with azide-containing molecules, yielding stable triazoles without the need for catalysts, making it valuable for antibody-drug conjugate (ADC) development and other bioconjugation strategies. -
ADC Linker
BCN-endo-PEG7-NH2 is a bifunctional ADC linker featuring a 7-unit PEG spacer and the lipophilic macrocyclic ligand endo-BCN. This compound enables efficient conjugation through click chemistry, allowing stable triazole formation with azide-containing molecules without the need for catalysts. BCN-endo-PEG7-NH2 is suitable for applications in antibody-drug conjugate (ADC) development and other bioconjugation techniques, facilitating targeted delivery and enhancing therapeutic efficacy in chemical biology research. -
ADC Linker
Alkyne-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates (ADCs). This compound facilitates stable attachment of cytotoxic agents to antibodies while enabling release in the target tissues or cells via specific enzymatic cleavage. Its properties make it suitable for research applications focused on enhancing the efficacy and selectivity of ADCs in cancer therapy and related studies. -
Azide Compound
DecarboxyBiotin-Alkyne is a click chemistry reagent featuring an azide group that facilitates bioconjugation reactions. This compound demonstrates high specificity and yield when used for labeling nucleic acids, lipids, and proteins. It is particularly valuable in diverse research applications, including cellular imaging and biomolecular interaction studies, allowing for efficient tagging and tracking of biomolecules. -
Fluorochrome Dye
Coumarin-PEG3-TCO is a fluorochrome dye that incorporates three PEG units to enhance solubility and stability. Its TCO group facilitates an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-bearing molecules, making it ideal for bioorthogonal labeling applications. This reagent is particularly useful in fluorescence microscopy and tracking cellular processes in live cells. -
Fluorochrome Dye
Coumarin-PEG2-TCO is a fluorescent dye that features a coumarin backbone modified with two PEG units. It utilizes a trans-cyclooctene (TCO) group to engage in an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing compounds. This compound is valuable in biological imaging applications and has potential uses in the development of targeted fluorescent probes for live-cell imaging and other bioconjugation strategies. -
Protein Label
diSulfo-Cy3 alkyne is a water-soluble dye that functions as a Click Chemistry reagent featuring an alkyne group. With absorption and emission characteristics comparable to those of the Cy3 fluorophore, it is suitable for precise labeling of proteins and other biological structures in aqueous environments. This compound is valuable for applications in fluorescence microscopy and bioconjugation studies, enhancing visualization and tracking of target biomolecules in diverse biological research. -
Dye
Sulfo-Cy5-TCO is a water-soluble fluorescent dye that incorporates a trans-cyclooctene (TCO) moiety, facilitating rapid and efficient click chemistry reactions with tetrazines and methyltetrazines. This reagent is designed for use in bioconjugation applications, offering high reactivity and speed that enhances labeling efficiency in various biological experiments. Its unique properties make Sulfo-Cy5-TCO valuable for researchers in fields such as cellular imaging, biomolecule tracking, and targeted drug delivery. -
Azide-Labelled Probe
Cy5 DBCO chloride is a DBCO-based probe designed for applications involving azide-labeled biomolecules. It facilitates copper-free "Click Chemistry" through strain-promoted alkyne-azide cycloaddition (SPAAC), enabling efficient imaging of azide-modified targets. This reagent is particularly valuable for studies involving bioorthogonal labeling and tracking of biomolecules in various research applications, including cellular visualization and bioimaging. -
Alkyne Modified BODIPY TMR-X
BODIPY TMR-X alkyne is an alkyne-modified fluorescent dye that exhibits strong orange fluorescence. It is designed to react with azides through the copper-catalyzed click reaction, enabling specific labeling and tracking in biological systems. With its stable properties across various pH conditions, BODIPY TMR-X alkyne is suitable for a range of applications in live-cell imaging, chemical biology, and other research requiring fluorescent tagging and detection. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
Dye
Dde Biotin-PEG4-TAMRA-PEG4 Alkyne is a dye derivative of TAMRA designed for fluorescent applications, featuring a cleavable biotin moiety. This compound contains alkyne groups that facilitate copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling its use in a variety of conjugation strategies. It is ideal for research applications involving biomolecular labeling and tracking in cellular and molecular studies. -
Dye
TAMRA-PEG4-methyltetrazine is a fluorescent dye derivative that features a tetrazine moiety for selective labeling applications. The presence of four polyethylene glycol (PEG) units enhances solubility and stability. This compound is designed to undergo inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) partners, making it suitable for bioconjugation and imaging studies in chemical biology research. -
Dye
TAMRA-PEG4-Alkyne is a fluorescent dye derivative of TAMRA that incorporates four PEG units, enhancing its solubility and biocompatibility. This compound features alkyne functional groups, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. Its unique properties make it valuable for various biological applications, including the labeling of biomolecules and the study of cellular processes through fluorescence imaging. -
Fluorescent Dye
TAMRA DBCO, 5-isomer is a fluorescent dye derivative of tetramethylrhodamine (TMR) featuring a dibenzocyclooctyne (DBCO) moiety. It enables rapid and efficient labeling of azide-containing biomolecules through a sterically promoted azide-alkyne cycloaddition (SPAAC) reaction, eliminating the need for copper catalysts. This compound is suitable for a wide range of applications, including the labeling of proteins, peptides, and nucleic acids, facilitating advanced studies in biochemistry and cellular imaging. -
Fluorescent Dye
OG 488 alkyne is a highly sensitive green-fluorescent dye designed for imaging azide-labeled biomolecules. It participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) to create a stable triazole linkage. This reagent is valuable for visualizing biomolecular interactions and dynamics, making it suitable for various applications in cellular imaging and bioconjugation studies. -
Fluorescent Dye
BP Fluor 488 TCO is a fluorescent dye that participates in the inverse-electron demand Diels-Alder cycloaddition reaction, reacting rapidly and selectively with tetrazines to form stable covalent linkages. This biocompatible reaction occurs without the need for copper catalysts or elevated temperatures, exhibiting an exceptionally high reaction rate constant (k > 800 M-1 s-1). BP Fluor 488 TCO is ideal for applications in bioorthogonal labeling, visualization, and tracking of biomolecules in live cells and various biological studies. -
Fluorescent Dye
ROX alkyne, 6-isomer is an alkyne derivative of the red-emitting fluorescent dye ROX (Rhodamine X, Rhodamine 101), known for its high quantum yield. This compound is particularly useful for fluorescent labeling of azide-containing biomolecules through copper-catalyzed click chemistry. Its applications include quantitative PCR and microscopy, making it an essential reagent for advanced imaging and detection in biochemical research. -
Fluorescent Dye
Cy7 alkyne chloride is a fluorescent dye derivative of Cyanine 7 (Cy7) featuring an alkyne functional group, with an excitation/emission wavelength of 740/770 nm. This reagent can undergo click chemistry reactions with azide-containing molecules, enabling the formation of stable covalent bonds. It is widely utilized in fluorescence imaging, bioconjugation applications, and cellular labeling studies, making it a valuable tool for researchers in bioorthogonal chemistry and related fields. -
click chemistry
FAM alkyne, 6-isomer is a click chemistry reagent designed for specific applications in 1,3-dipolar cycloaddition reactions with azido-labeled compounds. It facilitates the efficient formation of stably linked conjugates, making it a vital tool for bioconjugation studies and labeling in biological research. This compound is suitable for various applications, including imaging, drug delivery, and the development of biosensors. -
TARMA Dye
DBCO-PEG4-TAMRA is a PEG-conjugated TAMRA dye featuring a dibenzocyclooctyne (DBCO) moiety, facilitating efficient Click Chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for oligonucleotide labeling and is widely utilized in automated DNA sequencing applications. Its bioconjugation capabilities enhance the specificity and sensitivity of various research techniques, making it a valuable tool in molecular biology and biochemical studies. -
TAMRA Linker
TAMRA alkyne, 6-isomer serves as a versatile linker that enables the conjugation of TAMRA to various biomolecules. Its unique structure facilitates efficient labeling of proteins and nucleic acids, enhancing fluorescence detection and imaging applications. This reagent is essential for researchers utilizing fluorescence in assays, cellular imaging, and other applications requiring precise biomolecular visualization. -
SARS-CoV-2 RNA Degrader
MTDB-Alkyne is an alkyne-functionalized reagent designed for click chemistry applications. It serves as a synthetic precursor for Proximity-Induced Nucleic Acid Degraders (PINAD), facilitating the targeted degradation of SARS-CoV-2 RNA. Its unique mechanism allows for effective RNA manipulation, making it a valuable tool in antiviral research and therapies aimed at combating COVID-19. -
ADC Linker
TCO-PEG3-Biotin is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, featuring a three-unit polyethylene glycol (PEG) backbone. This compound includes a trans-cyclooctene (TCO) moiety that facilitates click chemistry through an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG3-Biotin is valuable in conjugating biomolecules, enabling targeted drug delivery and enhancing therapeutic efficacy in various biological research applications. -
ADC Linker
PTAD-PEG4-alkyne is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This 4-unit polyethylene glycol (PEG) linker features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. Its unique properties facilitate the targeted delivery of therapeutic agents, making it a valuable tool in the development of ADCs for research applications in cancer therapeutics and other fields. -
AOC Linker
Bis-Mal-Lysine-PEG4-DBCO is a dibenzocyclooctyne (DBCO) linker designed for use in alkyne-azide cycloaddition (AOC) applications. This compound facilitates the synthesis of AOC drugs, enabling the targeted inhibition of DMPK gene expression. Its efficient coupling properties make it a valuable tool for research in gene regulation and therapeutic development. -
Zanamivir-Linker
Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne is a conjugated compound featuring Zanamivir, a potent neuraminidase inhibitor. This compound facilitates the study of viral infections through its unique linker structure, enabling enhanced application in biochemical and biophysical assays. Researchers can utilize Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne for exploring therapeutic strategies and mechanisms related to viral pathogenesis. -
Integrin Ligand
Alkyne-cRGD is an integrin ligand that facilitates targeted binding to integrin proteins. This compound is valuable in the study of protein degraders and can be utilized in copper-catalyzed azide-alkyne cycloaddition reactions for bioconjugation applications. Its ability to selectively interact with integrins makes it a key tool in cancer research and various therapeutic studies. -
PSMA Inhibitor
TcO-ABX474 is a potent inhibitor of prostate-specific membrane antigen (PSMA), exhibiting a Kd value of 6.1 nM. It effectively inhibits the growth and metastasis of prostate cancer cells, making it a valuable tool for research in prostate cancer biology. This compound is suitable for studies investigating PSMA-mediated pathways and the development of targeted therapies for prostate cancer. -
STING Inhibitor
H-151 Alkyne is a selective inhibitor of STING (Stimulator of Interferon Genes). This compound demonstrates potential for modulating immune responses, making it valuable in the study of autoimmune diseases such as systemic lupus erythematosus and scleroderma, as well as autoinflammatory conditions. Its ability to interfere with STING pathways allows researchers to explore therapeutic strategies targeting these diseases. -
Click Chemistry
Thiobis-β-Galactose-propyne serves as a versatile click chemistry reagent with an alkyne functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Primarily, it acts as a multivalent inhibitor of galectin-3 (Gal-3), a protein implicated in various metabolic processes associated with cancer progression. This compound is suitable for applications in biochemical research focused on galectin-3-related pathways and provides a valuable tool for the development of targeted therapeutic strategies. -
STING Agonist
diABZI-V/C-DBCO is a potent STING agonist with an EC50 of 1.47 nM. It activates the STING pathway to promote the production of type I interferons, particularly IFN-β, enhancing immune responses. This compound acts as a substrate for cathepsin B, leading to the release of active diABZI-amine through cathepsin B-mediated cleavage. In preclinical studies using an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO has been shown to elevate serum levels of IFN-β and increase the frequency of granzyme B+ CD8+ T cells, making it valuable for research in triple-negative breast cancer. -
CD38 Inhibitor
6-Alkyne-F-araNAD is an irreversible inhibitor of CD38, a critical enzyme involved in the regulation of cyclic ADP-ribose and NAD metabolism. This compound enhances the efficacy of fluorescent probes, such as SR101-F-araNMN, allowing for improved visualization of intracellular CD38 localization. It serves as a valuable tool in studies related to immune signaling and cellular response mechanisms. -
Alkyne Lipid
Alkyne Cholesterol is a modified lipid featuring a terminal alkyne group, designed for click chemistry applications. This reagent facilitates highly specific conjugation reactions with azide-containing compounds in the presence of copper catalysts. Alkyne Cholesterol is instrumental for studying cellular cholesterol metabolism and localization, enabling detailed insights into lipid biology. -
PEGylated Derivative
DSPE-PEG2000-TCO is a PEGylated derivative that functions as a coupling partner in click chemistry through a reverse electron-demand Diels-Alder reaction. This compound facilitates the formation of covalent linkages with tetrazine-modified biomolecules, enhancing the stability of lipid nanoparticles (LNPs) while promoting efficient mRNA encapsulation. It plays a critical role in the development of EGFR-targeted and APN-targeted mRNA-loaded LNPs, supporting receptor-mediated endocytosis, effective mRNA delivery, and intestinal epithelial transcytosis in various research applications. -
Oleic Acid Analog
Oleic acid alkyne is an oleic acid analog featuring a terminal acetylene group. This modification enables its use in click chemistry, facilitating chemical ligation reactions. It allows for the hydroxylation of oleic acid by a microsomal cytochrome P-450-dependent system (ω-OAH). Through these reactions, fluorescent or biotin-labeled variants can be synthesized, making it a valuable tool for studying oleic acid metabolism and biological activity in various research applications. -
TRPC Agonist
IA-Alkyne is a TRPC channel (TRPC) agonist that facilitates the investigation of respiratory infections through enhanced channel activity. This compound serves as a versatile chemical probe for quantitative profiling of cysteine reactivity, enabling isotopic tagging. Additionally, IA-Alkyne features an alkyne functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry applications in various biological research studies. -
Lipid
DMG-PEG(2k)-DBCO is a clickable PEG lipid featuring a DBCO moiety. This compound is primarily utilized in the formulation of lipid nanoparticles, facilitating effective drug delivery applications. Its biochemical properties enable efficient conjugation processes, making it valuable for various bioconjugation strategies in lipid-based formulations. -
Phospholipid
DSPE-alkyne is a phospholipid functioning as a click chemistry reagent, characterized by the presence of an alkyne group. This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. DSPE-alkyne is widely utilized in bioconjugation applications, facilitating the formation of stable links between biomolecules for advanced research in drug delivery and molecular imaging. -
ω Alkynyl Lipid Surrogates
Arachidonic acid-alkyne is a ω-alkynyl lipid surrogate specifically designed for polyunsaturated fatty acid research. This compound demonstrates low oxidation rates, making it suitable for studies involving the tracking and analysis of polyunsaturated fatty acids in biological systems. Its unique chemical properties facilitate investigations into lipid metabolism and signaling pathways, expanding its utility in various biochemical and pharmacological applications. -
PROTAC Linker
Tetrazine-Ph-NHCO-C3-NHS ester serves as a PEG-based PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a Tetrazine group that enables a selective inverse electron demand Diels-Alder reaction (iEDDA) with TCO-containing molecules. It is instrumental in developing targeted protein degradation strategies in chemical research, enhancing the precision of therapeutic interventions. -
PROTAC Linker
DBCO-PEG3-NHS is a PROTAC linker featuring an alkynyl (DBCO) and N-hydroxysuccinimide (NHS) ester group, facilitating the chemical modification of proteins and antibodies. This reagent is instrumental in the synthesis of PROTACs, enhancing targeted protein degradation applications, as well as contributing to drug delivery systems and the development of biosensors and diagnostic assays. It allows for precise conjugation chemistry, enabling innovative research in therapeutic development and biomolecular interactions. -
PROTAC Linker
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation molecular constructs. This compound features a tetrazine moiety that facilitates click chemistry via an inverse electron demand Diels-Alder reaction (iEDDA) with trans-cyclooctene (TCO) derivatives. Its biological activity allows for the selective recruitment of E3 ligases, making it a valuable tool for researchers studying protein regulation and degradation pathways. This reagent is essential for the development of innovative therapies utilizing PROTAC technology. -
PROTAC Linker
endo-BCN-PEG2-C2-NHS ester functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This linker is designed to enhance target specificity and efficacy in targeted protein degradation research. Its properties make it suitable for studies focusing on cellular signaling, protein homeostasis, and therapeutic interventions in various diseases.
