Catalog No.
Product Name
Application
Product Information
Citations
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ADC Linker
BCN-PEG3-Biotin is a non-cleavable three-unit polyethylene glycol (PEG) linker specifically designed for use in antibody-drug conjugates (ADCs). This reagent features a bicyclo[6.1.0]nonyne (BCN) group that facilitates strain-promoted azide-alkyne cycloaddition (SPAAC) with azide-containing molecules. It serves as a valuable tool in the synthesis of ADCs, enhancing stability while providing biotin functionality for further bioconjugation applications in research and development. -
ADC/PROTAC Linker
DBCO-PEG4-DBCO is a PEG-based linker primarily designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound features a dibenzocyclooctyne (DBCO) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatile reactivity enables the development of targeted therapeutics, enhancing specificity and efficacy in research applications focused on protein degradation and targeted delivery systems. -
Click Chemistry Reagent
TCO-PEG3-maleimide is a click chemistry reagent that facilitates the efficient conjugation of trans-cyclooctene (TCO) moieties to thiol-containing molecules, including antibodies and cysteine-containing peptides. Through a rapid and selective reaction with thiol groups, this compound is valuable for a variety of bioconjugation applications. Its unique properties enable researchers to explore novel therapeutic strategies and enhance the development of bioconjugates in chemical biology. -
ADC Linker
DBCO-PEG3-oxyamine is a non-cleavable linker specifically designed for antibody-drug conjugate (ADC) synthesis. Featuring a DBCO moiety, this reagent facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its application in conjugating antibodies to therapeutic agents enhances targeted delivery and efficacy in cancer research and drug development. -
ADC Linker
BCN-endo-PEG2-maleimide is a bifunctional ADC linker featuring two polyethylene glycol (PEG) units and a maleimide group. It acts as a bioconjugation reagent, facilitating stable linkages to azide-containing molecules through a copper-free click chemistry reaction, yielding stable triazoles. The maleimide moiety allows for selective conjugation to thiol groups, making it suitable for drug delivery applications. This compound is primarily utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugation strategies. -
ADC Linker
DBCO-Sulfo-Link-biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). It features a DBCO moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is valuable in the development of targeted therapies, facilitating precise delivery of cytotoxic agents to tumor cells while minimizing off-target effects. Its application enhances the effectiveness of therapeutic strategies in oncology and related fields. -
ADC Linker
endo-BCN-PEG4-acid is a versatile cleavable linker designed for antibody-drug conjugates (ADCs), facilitating targeted drug delivery. Featuring a bicyclo[6.1.0]nonyne (BCN) moiety, this compound enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is particularly useful in bioconjugation and drug development applications, allowing for the precise attachment of therapeutic agents to antibodies. -
PROTAC Linkers
BCN-PEG4-NHS ester is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves the BCN group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for enabling targeted protein degradation and enhancing the therapeutic potential of PROTACs in chemical biology research. Additionally, it serves as an effective tool for bioconjugation applications, expanding the versatility of synthetic approaches in drug discovery. -
ADC Linker
DBCO-NHCO-S-S-NHS ester is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound contains a DBCO group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application is crucial in the construction of targeted therapies, enabling the selective delivery of cytotoxic agents to specific cells. -
ADC Linker
DBCO-C6-acid is a non-cleavable ADC linker that facilitates the formation of antibody-drug conjugates (ADCs). Its unique DBCO moiety allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is particularly useful in the synthesis of carmaphycin analogues, enabling targeted delivery of therapeutic agents for enhanced efficacy in research applications related to targeted cancer therapies. -
ADC/PROTAC Linker
TCO-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the conjugation of therapeutics, enabling targeted degradation of specific proteins via the ubiquitin-proteasome pathway. Its unique properties make it suitable for advancing research in targeted therapies and optimizing drug delivery systems. -
ADC Linker
Azido-methyltetrazine di-arm linker is a novel linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This multivalent linker facilitates the conjugation of therapeutic agents to antibodies, enhancing the efficacy and targeting capabilities of ADCs. It is an essential reagent for researchers exploring the development of targeted cancer therapies and improving the selectivity of drug delivery systems. -
ADC/PROTAC Linker
DBCO-PEG4-amine is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This versatile cleavable linker allows for efficient conjugation through its DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its applications extend to the creation of homobifunctional cross-linkers, such as FPM-PEG4-DBCO, facilitating advanced drug delivery and targeted degradation strategies in chemical biology research. -
ADC Linker
BCN-exo-PEG7-maleimide is an ADC linker featuring a polyethylene glycol (PEG) spacer of seven units, facilitating improved solubility and stability. This compound incorporates the bidentate macrocyclic ligand BCN, enabling efficient synthesis of macrocyclic complexes. In click chemistry applications, BCN selectively reacts with azide-containing molecules to yield stable triazoles without the need for catalysts. Additionally, the maleimide functional group undergoes hydrolytic degradation, making it suitable for drug delivery research. -
Cycloalkynes Compound
Cy5.5 DBCO is a cycloalkyne-based click chemistry reagent featuring a cyanine 5.5 fluorophore. The presence of the DBCO moiety facilitates copper-free, biocompatible click reactions characterized by rapid kinetics and enhanced stability. This reagent is widely utilized in bioconjugation applications, enabling efficient labeling of biomolecules for imaging and detection in various biological studies. -
ADC linker
Tetrazine-SS-Biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring a Tetrazine moiety, it facilitates the inverse electron demand Diels-Alder reaction with trans-cyclooctene (TCO) derivatives. This unique reactivity enables precise targeting and controlled release of therapeutic agents, making it valuable in cancer research and the development of targeted therapies. -
ADC Linker
DBCO-PEG2-DBCO is a versatile click chemistry reagent featuring two terminal dibenzocyclooctyne (DBCO) groups connected by a polyethylene glycol (PEG) linker. This compound is engineered for efficient, copper-free click reactions, making it particularly valuable in the development of antibody-drug conjugates (ADCs). Its unique chemical properties promote strong and selective labeling, enabling researchers to explore novel therapeutic applications and enhance drug delivery systems in biomedical research. This reagent is intended for research use only. -
ADC Linker
BCN-PEG3-OH is a non-cleavable linker specifically designed for antibody-drug conjugate (ADC) synthesis. As a click chemistry reagent, it features a bicyclo[6.1.0]nonyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound supports robust conjugation strategies, enhancing the delivery of cytotoxic agents in targeted cancer therapies. Its efficiency makes it an invaluable tool in the development of ADCs for various research applications. -
ADC Linker
Tetrazine-PEG4-amine hydrochloride functions as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) functionalized molecules. It is essential for the development of targeted therapies, facilitating the selective delivery of cytotoxic agents to cancer cells while minimizing off-target effects. -
Click Chemistry Reagent
TCO-NHS Ester (axial) is a versatile click chemistry reagent primarily used for site-specific labeling in amine reactions. The compound features TCO groups that participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. It is valuable in bioconjugation and molecular imaging applications, enabling researchers to construct complex biomolecular structures. -
ADC Linker
Gly-Gly-Gly-PEG3-TCO is a polyethylene glycol (PEG) linker featuring a TCO moiety, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates click chemistry through its ability to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. Its application in ADC development enhances targeted delivery and therapeutic efficacy in the treatment of various diseases. -
ADC Linker
BCN-SS-NHS is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties enhance the targeting and delivery of therapeutic agents, making it a valuable tool in the development of ADCs for various cancer research applications. -
ADC Linker
DBCO-PEG2-Val-Cit-PAB-MMAE is an antibody-drug conjugate (ADC) linker that employs a DBCO group for efficient click chemistry with azide moieties. This reagent incorporates a Val-Cit dipeptide, which is cleavable by proteases, facilitating the targeted release of the MMAE warhead within cells through an elimination mechanism. Its design is optimized for applications in targeted cancer therapy, enhancing the specificity and efficacy of drug delivery systems. -
ADC Linker
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker that facilitates targeted drug delivery. The Val-Cit moiety is specifically cleaved by Cathepsin B, enabling the release of an amine-containing payload when substituted. The DBCO group allows for efficient click chemistry with azide-bearing compounds, making this linker suitable for various antibody-drug conjugate applications in therapeutic research. -
ADC Linker
DBCO-PEG3-acid is a non-cleavable ADC linker featuring a 3-unit polyethylene glycol (PEG) chain. Its primary mechanism involves the strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling effective conjugation in the synthesis of antibody-drug conjugates (ADCs). This reagent is particularly valuable in therapeutic research applications, facilitating targeted drug delivery and enhancing the pharmacological properties of antibody-based treatments. -
ADC Linker
DBCO-PEG24-Maleimide is a versatile linker featuring a maleimide group and a DBCO (dibenzocyclooctyne) moiety. This compound is ideal for conjugating thiol-containing biomolecules and facilitates efficient click chemistry reactions with azide-bearing substrates. Its unique structure enables stable linkages, making it suitable for applications in antibody-drug conjugates (ADCs) and other bioconjugation frameworks in chemical biology research. -
ADC Linker
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery applications. The Val-Ala sequence enables selective cleavage by Cathepsin B, facilitating the release of the therapeutic payload. The incorporation of a PEG spacer enhances aqueous solubility, while the DBCO group is suitable for Click Chemistry reactions due to its reactivity. Additionally, the PNP moiety serves as an efficient leaving group, making this compound valuable in bioconjugation and therapeutic development. -
ADC Linker
Methyltetrazine-DBCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Additionally, the inclusion of a tetrazine moiety allows for inverse electron demand Diels-Alder reactions (iEDDA) with trans-cyclooctene (TCO) compounds. Methyltetrazine-DBCO is an essential reagent for researchers developing targeted therapies through click chemistry methodologies. -
Fluorescent Dye
Sulfo-cyanine7 alkyne is a water-soluble near-infrared fluorescent dye designed for use in copper-catalyzed click chemistry. This compound features a sulfonated terminal alkyne, enabling efficient conjugation with azides in aqueous conditions. Sulfo-cyanine7 alkyne is ideal for biological imaging applications and can enhance the visualization of biomolecules in various research settings. -
Fluorescent Dye
Sulfo-cyanine7 alkyne potassium is a water-soluble near-infrared fluorescent dye designed for applications in copper-catalyzed click chemistry. Its sulfonated terminal alkyne enables efficient conjugation with azides under aqueous conditions. This compound is ideal for use in biological imaging and labeling studies, providing enhanced detection of biomolecules in various research applications. -
Fluorescent Dye
Bodipy TR alkyne is a boron dipyrromethene-based fluorescent dye designed for applications in the ROX (Texas Red) channel. This versatile fluorophore exhibits strong fluorescence, making it suitable for use in microscopy and fluorescence polarization assays. The terminal alkyne moiety facilitates efficient incorporation into biomolecular probes via copper-catalyzed click chemistry, enabling a wide range of research applications including cellular imaging and labeling studies. -
Fluorescent Dye
5-ROX-alkyne is a rhodamine-based fluorescent dye designed for the labeling of DNA fragments. It exhibits strong fluorescence, facilitating the visualization of results in capillary electrophoresis genotyping and gel shift assays. This reagent is essential for applications in nucleic acid analysis and characterization, enabling researchers to obtain precise and reliable data in molecular biology experiments. -
Click Chemistry Reagent
Trisulfo-Cy3-Alkyne is a water-soluble click chemistry reagent containing an alkyne functional group, facilitating the attachment of trisulfated Cy3 to azide-bearing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAc). This reagent exhibits significant biological activity as a fluorescent probe, characterized by its bright fluorescence and photostability, making it suitable for a variety of imaging techniques, including gel detection and microscopy. It is designed for use in research applications requiring precise labeling and tracking of biomolecules. -
TARMA Dye
DBCO-PEG4-TAMRA is a PEG-conjugated TAMRA dye featuring a dibenzocyclooctyne (DBCO) moiety, facilitating efficient Click Chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for oligonucleotide labeling and is widely utilized in automated DNA sequencing applications. Its bioconjugation capabilities enhance the specificity and sensitivity of various research techniques, making it a valuable tool in molecular biology and biochemical studies. -
TAMRA Linker
TAMRA alkyne, 6-isomer serves as a versatile linker that enables the conjugation of TAMRA to various biomolecules. Its unique structure facilitates efficient labeling of proteins and nucleic acids, enhancing fluorescence detection and imaging applications. This reagent is essential for researchers utilizing fluorescence in assays, cellular imaging, and other applications requiring precise biomolecular visualization. -
SARS-CoV-2 RNA Degrader
MTDB-Alkyne is an alkyne-functionalized reagent designed for click chemistry applications. It serves as a synthetic precursor for Proximity-Induced Nucleic Acid Degraders (PINAD), facilitating the targeted degradation of SARS-CoV-2 RNA. Its unique mechanism allows for effective RNA manipulation, making it a valuable tool in antiviral research and therapies aimed at combating COVID-19. -
ADC Linker
TCO-PEG3-Biotin is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, featuring a three-unit polyethylene glycol (PEG) backbone. This compound includes a trans-cyclooctene (TCO) moiety that facilitates click chemistry through an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG3-Biotin is valuable in conjugating biomolecules, enabling targeted drug delivery and enhancing therapeutic efficacy in various biological research applications. -
ADC Linker
PTAD-PEG4-alkyne is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This 4-unit polyethylene glycol (PEG) linker features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. Its unique properties facilitate the targeted delivery of therapeutic agents, making it a valuable tool in the development of ADCs for research applications in cancer therapeutics and other fields. -
AOC Linker
Bis-Mal-Lysine-PEG4-DBCO is a dibenzocyclooctyne (DBCO) linker designed for use in alkyne-azide cycloaddition (AOC) applications. This compound facilitates the synthesis of AOC drugs, enabling the targeted inhibition of DMPK gene expression. Its efficient coupling properties make it a valuable tool for research in gene regulation and therapeutic development. -
Zanamivir-Linker
Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne is a conjugated compound featuring Zanamivir, a potent neuraminidase inhibitor. This compound facilitates the study of viral infections through its unique linker structure, enabling enhanced application in biochemical and biophysical assays. Researchers can utilize Di(zanamivir-amide(N-Me)-PEG1)-N-PEG4-alkyne for exploring therapeutic strategies and mechanisms related to viral pathogenesis. -
Integrin Ligand
Alkyne-cRGD is an integrin ligand that facilitates targeted binding to integrin proteins. This compound is valuable in the study of protein degraders and can be utilized in copper-catalyzed azide-alkyne cycloaddition reactions for bioconjugation applications. Its ability to selectively interact with integrins makes it a key tool in cancer research and various therapeutic studies. -
PSMA Inhibitor
TcO-ABX474 is a potent inhibitor of prostate-specific membrane antigen (PSMA), exhibiting a Kd value of 6.1 nM. It effectively inhibits the growth and metastasis of prostate cancer cells, making it a valuable tool for research in prostate cancer biology. This compound is suitable for studies investigating PSMA-mediated pathways and the development of targeted therapies for prostate cancer. -
STING Inhibitor
H-151 Alkyne is a selective inhibitor of STING (Stimulator of Interferon Genes). This compound demonstrates potential for modulating immune responses, making it valuable in the study of autoimmune diseases such as systemic lupus erythematosus and scleroderma, as well as autoinflammatory conditions. Its ability to interfere with STING pathways allows researchers to explore therapeutic strategies targeting these diseases. -
STING Agonist
diABZI-V/C-DBCO is a potent STING agonist with an EC50 of 1.47 nM. It activates the STING pathway to promote the production of type I interferons, particularly IFN-β, enhancing immune responses. This compound acts as a substrate for cathepsin B, leading to the release of active diABZI-amine through cathepsin B-mediated cleavage. In preclinical studies using an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO has been shown to elevate serum levels of IFN-β and increase the frequency of granzyme B+ CD8+ T cells, making it valuable for research in triple-negative breast cancer. -
CD38 Inhibitor
6-Alkyne-F-araNAD is an irreversible inhibitor of CD38, a critical enzyme involved in the regulation of cyclic ADP-ribose and NAD metabolism. This compound enhances the efficacy of fluorescent probes, such as SR101-F-araNMN, allowing for improved visualization of intracellular CD38 localization. It serves as a valuable tool in studies related to immune signaling and cellular response mechanisms. -
Oleic Acid Analog
Oleic acid alkyne is an oleic acid analog featuring a terminal acetylene group. This modification enables its use in click chemistry, facilitating chemical ligation reactions. It allows for the hydroxylation of oleic acid by a microsomal cytochrome P-450-dependent system (ω-OAH). Through these reactions, fluorescent or biotin-labeled variants can be synthesized, making it a valuable tool for studying oleic acid metabolism and biological activity in various research applications. -
TRPC Agonist
IA-Alkyne is a TRPC channel (TRPC) agonist that facilitates the investigation of respiratory infections through enhanced channel activity. This compound serves as a versatile chemical probe for quantitative profiling of cysteine reactivity, enabling isotopic tagging. Additionally, IA-Alkyne features an alkyne functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry applications in various biological research studies. -
Lipid
DMG-PEG(2k)-DBCO is a clickable PEG lipid featuring a DBCO moiety. This compound is primarily utilized in the formulation of lipid nanoparticles, facilitating effective drug delivery applications. Its biochemical properties enable efficient conjugation processes, making it valuable for various bioconjugation strategies in lipid-based formulations. -
Phospholipid
DSPE-alkyne is a phospholipid functioning as a click chemistry reagent, characterized by the presence of an alkyne group. This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. DSPE-alkyne is widely utilized in bioconjugation applications, facilitating the formation of stable links between biomolecules for advanced research in drug delivery and molecular imaging. -
Alkyne Lipid
Alkyne Cholesterol is a modified lipid featuring a terminal alkyne group, designed for click chemistry applications. This reagent facilitates highly specific conjugation reactions with azide-containing compounds in the presence of copper catalysts. Alkyne Cholesterol is instrumental for studying cellular cholesterol metabolism and localization, enabling detailed insights into lipid biology.
