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DBCO-PEG4-VC-PAB-DMEA-PNU-159682

Catalog No.: A41387
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It combines the DBCO-PEG4-VC-PAB linker with the potent cytotoxin DMEA-PNU-159682, which includes active metabolites of nemorubicin. This compound leverages click chemistry, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 serves as an effective tool in targeted cancer therapy research and the development of innovative ADCs.
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 2259318-56-2 Drug-Linker Conjugate for ADC
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1mg
$1,535.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It combines the DBCO-PEG4-VC-PAB linker with the potent cytotoxin DMEA-PNU-159682, which includes active metabolites of nemorubicin. This compound leverages click chemistry, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 serves as an effective tool in targeted cancer therapy research and the development of innovative ADCs.
Product Information
Catalog NumA41387
FormulaC86H106N10O26
Molecular Weight1695.81
CAS Number2259318-56-2
SMILESC[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCN(C)C(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCC(NCCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)C=C6)=O)=O)=O)(O)C4)C(O)=C%10C(C(C%11=C(OC)C=CC=C%11C%10=O)=O)=C5O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC
Click Chemistry > DBCO