Catalog No.
Product Name
Application
Product Information
Citations
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ADC Linker
DBCO-PEG2-C2-acid is an efficient ADC linker that facilitates the synthesis of Antibody-Drug Conjugates (ADCs). This compound utilizes the DBCO (dibenzocyclooctyne) chemistry for site-specific conjugation, enhancing the stability and efficacy of the resulting ADCs. It is essential for researchers focused on developing targeted therapies in oncology and other therapeutic areas, allowing for improved drug delivery and minimized off-target effects. -
ADC Linker
DBCO-S-S-acid is a cleavable linker designed for the construction of antibody-drug conjugates (ADCs). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for selective and efficient conjugation. This reagent is essential in bioconjugation strategies aimed at enhancing targeted therapeutic delivery in cancer research and other therapeutic applications. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-acid is a PEG-based linker designed for application in antibody-drug conjugates (ADCs) and PROTAC synthesis. This linker features a DBCO group that participates in strain-promoted alkyne-azide cycloaddition (SPAAC), facilitating selective conjugation with azide-containing molecules. Its chemical properties make it ideal for developing targeted therapeutics that can modulate protein levels in biological research, enhancing experimental outcomes in drug discovery and development. -
Azide Compound
Sulfo DBCO-PEG3-acid is a click chemistry reagent featuring an azide group that facilitates copper-free Click Chemistry reactions through its DBCO moiety. The compound's hydrophilic PEG linker and sulfonate group enhance solubility in aqueous environments, making it suitable for biological applications. The terminal carboxylic acid reacts with primary amine groups in the presence of coupling agents such as EDC or HATU, generating stable amide bonds for bioconjugation studies. This reagent is intended for research purposes only. -
Click Chemistry Reagent
Sulfo DBCO-TFP Ester is a water-soluble click chemistry reagent that features a sulfo group. This compound facilitates the efficient and straightforward conjugation of sulfo-DBCO moieties to amine-containing biomolecules. Its applications include labeling, drug delivery, and the development of bioconjugates in various biochemical and biomedical research fields. -
ADC Linker
DBCO-NHS ester is a non-cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). It serves as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for bioconjugation applications, allowing for the stable attachment of therapeutics to antibodies, thereby enhancing the efficacy and specificity of targeted drug delivery in cancer research. -
ADC Linker
DBCO-PEG4-Maleimide is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. It is essential for applications in targeted drug delivery, enhancing the therapeutic efficacy of ADCs while minimizing off-target effects. -
ADC/PROTAC Linker
DBCO-PEG5-NHS ester is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG/alkyl/ether-based reagent facilitates the formation of stable covalent bonds through strain-promoted alkyne-azide cycloaddition (SPAAC), targeting azide-functionalized molecules. Its defined structure enhances the efficacy and specificity of therapeutic compounds, making it a valuable tool for researchers in the development of targeted therapies. -
ADC Linker
Gly-Gly-Gly-PEG4-DBCO is a polyethylene glycol (PEG) linker designed for use in antibody-drug conjugates (ADCs). Featuring a dibenzocyclooctyne (DBCO) functional group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. Its high stability and efficiency make it an essential tool in the development of targeted therapeutics for improved delivery of cytotoxic drugs. -
ADC Linker
DBCO-Maleimide is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). As a click chemistry reagent, it features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property enables seamless conjugation and enhances the therapeutic efficacy of ADCs, making DBCO-Maleimide an essential tool in bioconjugation and targeted drug delivery research. -
Click Chemical Agent
DBCO-PEG24-NHS ester is a click chemistry reagent designed for selective conjugation through the reaction with primary amines, such as lysine side chains or aminosilane-coated surfaces, under neutral to slightly basic conditions. The NHS ester facilitates the formation of a stable covalent bond, while the hydrophilic PEG spacer enhances water solubility and offers a flexible linkage that reduces steric hindrance during ligation. This compound is particularly suited for applications in bioconjugation and the development of targeted delivery systems. -
ADC Linker
DBCO-Sulfo-NHS ester sodium is an efficient ADC linker designed for the synthesis of antibody-drug conjugates (ADCs), facilitating targeted drug delivery. This reagent features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatile coupling capabilities make it an essential tool for researchers developing novel therapeutics in cancer and other diseases. -
ADC Linker
Fluorescein-DBCO is a non-cleavable linker designed for use in the formation of antibody-drug conjugates (ADCs). This compound features a dibenzocyclooctyne (DBCO) group, enabling it to participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its unique properties make Fluorescein-DBCO an essential tool for researchers focusing on targeted drug delivery and cancer therapy applications through ADC development. -
ADC Linker
DBCO-Val-Cit-PABC-PNP is a cleavable linker designed for the construction of antibody-drug conjugates (ADCs). This compound features a DBCO moiety that participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. Its unique structure enables precise conjugation and controlled release of cytotoxic agents, making it essential for advancing ADC research and therapeutic development. -
Azide Compound
DBCO-PEG2-NHS ester is a click chemistry reagent with an azide group, designed to facilitate bioconjugation through reactions with primary amines, such as lysine side chains or aminosilane-coated surfaces. This PEG-based compound features an NHS ester, which enables the formation of stable covalent bonds under neutral to slightly basic conditions. The hydrophilic polyethylene glycol (PEG) spacer enhances solubility and adds flexibility, reducing steric hindrance during ligation. DBCO-PEG2-NHS ester is ideal for applications in copper-free Click Chemistry and other bioconjugation studies. -
ADC Linker
DBCO-CONH-S-S-NHS ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). Its primary mechanism involves the DBCO group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent plays a crucial role in the development of ADCs, allowing for targeted delivery of cytotoxic agents and enhancing therapeutic efficacy. Suitable for various applications in chemical biology and bioconjugation research. -
ADC/PROTAC Linker
DBCO-PEG4-DBCO is a PEG-based linker primarily designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This compound features a dibenzocyclooctyne (DBCO) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatile reactivity enables the development of targeted therapeutics, enhancing specificity and efficacy in research applications focused on protein degradation and targeted delivery systems. -
ADC Linker
DBCO-PEG3-oxyamine is a non-cleavable linker specifically designed for antibody-drug conjugate (ADC) synthesis. Featuring a DBCO moiety, this reagent facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its application in conjugating antibodies to therapeutic agents enhances targeted delivery and efficacy in cancer research and drug development. -
ADC Linker
DBCO-Sulfo-Link-biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). It features a DBCO moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is valuable in the development of targeted therapies, facilitating precise delivery of cytotoxic agents to tumor cells while minimizing off-target effects. Its application enhances the effectiveness of therapeutic strategies in oncology and related fields. -
ADC Linker
DBCO-NHCO-S-S-NHS ester is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound contains a DBCO group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application is crucial in the construction of targeted therapies, enabling the selective delivery of cytotoxic agents to specific cells. -
ADC Linker
DBCO-C6-acid is a non-cleavable ADC linker that facilitates the formation of antibody-drug conjugates (ADCs). Its unique DBCO moiety allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is particularly useful in the synthesis of carmaphycin analogues, enabling targeted delivery of therapeutic agents for enhanced efficacy in research applications related to targeted cancer therapies. -
ADC/PROTAC Linker
DBCO-PEG4-amine is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This versatile cleavable linker allows for efficient conjugation through its DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its applications extend to the creation of homobifunctional cross-linkers, such as FPM-PEG4-DBCO, facilitating advanced drug delivery and targeted degradation strategies in chemical biology research. -
Cycloalkynes Compound
Cy5.5 DBCO is a cycloalkyne-based click chemistry reagent featuring a cyanine 5.5 fluorophore. The presence of the DBCO moiety facilitates copper-free, biocompatible click reactions characterized by rapid kinetics and enhanced stability. This reagent is widely utilized in bioconjugation applications, enabling efficient labeling of biomolecules for imaging and detection in various biological studies. -
ADC Linker
DBCO-PEG2-DBCO is a versatile click chemistry reagent featuring two terminal dibenzocyclooctyne (DBCO) groups connected by a polyethylene glycol (PEG) linker. This compound is engineered for efficient, copper-free click reactions, making it particularly valuable in the development of antibody-drug conjugates (ADCs). Its unique chemical properties promote strong and selective labeling, enabling researchers to explore novel therapeutic applications and enhance drug delivery systems in biomedical research. This reagent is intended for research use only. -
ADC Linker
DBCO-PEG2-Val-Cit-PAB-MMAE is an antibody-drug conjugate (ADC) linker that employs a DBCO group for efficient click chemistry with azide moieties. This reagent incorporates a Val-Cit dipeptide, which is cleavable by proteases, facilitating the targeted release of the MMAE warhead within cells through an elimination mechanism. Its design is optimized for applications in targeted cancer therapy, enhancing the specificity and efficacy of drug delivery systems. -
ADC Linker
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker that facilitates targeted drug delivery. The Val-Cit moiety is specifically cleaved by Cathepsin B, enabling the release of an amine-containing payload when substituted. The DBCO group allows for efficient click chemistry with azide-bearing compounds, making this linker suitable for various antibody-drug conjugate applications in therapeutic research. -
ADC Linker
DBCO-PEG3-acid is a non-cleavable ADC linker featuring a 3-unit polyethylene glycol (PEG) chain. Its primary mechanism involves the strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling effective conjugation in the synthesis of antibody-drug conjugates (ADCs). This reagent is particularly valuable in therapeutic research applications, facilitating targeted drug delivery and enhancing the pharmacological properties of antibody-based treatments. -
ADC Linker
DBCO-PEG24-Maleimide is a versatile linker featuring a maleimide group and a DBCO (dibenzocyclooctyne) moiety. This compound is ideal for conjugating thiol-containing biomolecules and facilitates efficient click chemistry reactions with azide-bearing substrates. Its unique structure enables stable linkages, making it suitable for applications in antibody-drug conjugates (ADCs) and other bioconjugation frameworks in chemical biology research. -
ADC Linker
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery applications. The Val-Ala sequence enables selective cleavage by Cathepsin B, facilitating the release of the therapeutic payload. The incorporation of a PEG spacer enhances aqueous solubility, while the DBCO group is suitable for Click Chemistry reactions due to its reactivity. Additionally, the PNP moiety serves as an efficient leaving group, making this compound valuable in bioconjugation and therapeutic development. -
ADC Linker
Methyltetrazine-DBCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Additionally, the inclusion of a tetrazine moiety allows for inverse electron demand Diels-Alder reactions (iEDDA) with trans-cyclooctene (TCO) compounds. Methyltetrazine-DBCO is an essential reagent for researchers developing targeted therapies through click chemistry methodologies. -
TARMA Dye
DBCO-PEG4-TAMRA is a PEG-conjugated TAMRA dye featuring a dibenzocyclooctyne (DBCO) moiety, facilitating efficient Click Chemistry through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for oligonucleotide labeling and is widely utilized in automated DNA sequencing applications. Its bioconjugation capabilities enhance the specificity and sensitivity of various research techniques, making it a valuable tool in molecular biology and biochemical studies. -
AOC Linker
Bis-Mal-Lysine-PEG4-DBCO is a dibenzocyclooctyne (DBCO) linker designed for use in alkyne-azide cycloaddition (AOC) applications. This compound facilitates the synthesis of AOC drugs, enabling the targeted inhibition of DMPK gene expression. Its efficient coupling properties make it a valuable tool for research in gene regulation and therapeutic development. -
STING Agonist
diABZI-V/C-DBCO is a potent STING agonist with an EC50 of 1.47 nM. It activates the STING pathway to promote the production of type I interferons, particularly IFN-β, enhancing immune responses. This compound acts as a substrate for cathepsin B, leading to the release of active diABZI-amine through cathepsin B-mediated cleavage. In preclinical studies using an orthotopic mouse model of breast cancer, diABZI-V/C-DBCO has been shown to elevate serum levels of IFN-β and increase the frequency of granzyme B+ CD8+ T cells, making it valuable for research in triple-negative breast cancer. -
Lipid
DMG-PEG(2k)-DBCO is a clickable PEG lipid featuring a DBCO moiety. This compound is primarily utilized in the formulation of lipid nanoparticles, facilitating effective drug delivery applications. Its biochemical properties enable efficient conjugation processes, making it valuable for various bioconjugation strategies in lipid-based formulations. -
PROTAC Linker
DBCO-PEG3-NHS is a PROTAC linker featuring an alkynyl (DBCO) and N-hydroxysuccinimide (NHS) ester group, facilitating the chemical modification of proteins and antibodies. This reagent is instrumental in the synthesis of PROTACs, enhancing targeted protein degradation applications, as well as contributing to drug delivery systems and the development of biosensors and diagnostic assays. It allows for precise conjugation chemistry, enabling innovative research in therapeutic development and biomolecular interactions. -
PROTAC Linker
Sulfo DBCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimera (PROTAC) synthesis. This compound facilitates targeted degradation of proteins by connecting E3 ubiquitin ligases to specific proteins of interest. Its application in PROTAC development enhances selectivity and efficacy in degradation pathways, supporting research in targeted protein modulation and therapeutic interventions. -
PROTAC Linker
DBCO-PEG4-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs. It features a dibenzocyclooctyne (DBCO) moiety, enabling reaction via strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for the development of targeted protein degradation strategies, facilitating precise modular assembly in therapeutic research applications. -
PROTAC Linker
DBCO-PEG4-Desthiobiotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a DBCO moiety that facilitates efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for developing targeted protein degradation tools, enabling researchers to investigate protein function and cellular pathways through controlled protein turnover. -
PROTAC Linkers
Oleic-DBCO is a versatile PROTAC linker featuring an alkyl chain structure. It serves as a click chemistry reagent, incorporating a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property makes Oleic-DBCO valuable for the synthesis of targeted protein degradation compounds in chemical biology research, enabling the study of protein function and drug development. -
PROTAC Linkers
DBCO-PEG1-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It facilitates the development of targeted protein degradation strategies, making it valuable in research applications focused on therapeutic interventions targeting specific proteins. -
PROTAC Linker
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties make it suitable for applications in cellular proteomic studies and drug discovery, highlighting its utility in targeted protein degradation research. -
PROTAC Linkers
DBCO-PEG5-DBCO is a PEG-based linker specifically designed for synthesizing PROTACs. Featuring a dibenzocyclooctyne (DBCO) moiety, this reagent enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its versatility makes it an invaluable tool in the development of targeted protein degradation strategies, facilitating research into novel therapeutic approaches in various biological systems. -
PROTAC Linker
Sulfo DBCO-amine is a versatile PROTAC linker designed to facilitate the synthesis of PROTACs. This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for efficient and selective conjugation. Its application in chemical biology is crucial for developing targeted protein degraders, thereby advancing research in protein modulation and therapeutic intervention. -
PROTAC linker
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based linker designed for PROTAC synthesis, functioning primarily through click chemistry. Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent enhances the development of targeted protein degradation strategies, proving valuable in various biochemical applications and studies aimed at modulating protein levels within cellular systems. -
PROTAC Linker
DBCO-PEG4-alcohol is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. Featuring a DBCO group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in the development of targeted protein degradation strategies underscores its significance in chemical biology and therapeutic research. -
PROTAC Linkers
DBCO-PEG12-Maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, enabling efficient and selective conjugation. This chemical reagent is valuable in targeted protein degradation studies and the development of novel therapeutic strategies. -
PROTAC linker
DSPE-PEG4-DBCO is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs. This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. As a versatile click chemistry reagent, DSPE-PEG4-DBCO facilitates the construction of bifunctional probes for targeted protein degradation studies and other applications in chemical biology. -
PROTAC Linkers
DBCO-NHCO-PEG6-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the conjugation of biotin for enhanced target protein degradation. This reagent is ideal for applications in chemical biology and drug discovery, particularly in the development of advanced therapeutic modalities. -
PROTAC Linker
PC DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs, functioning as a critical component in targeted protein degradation. This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized molecules. It serves as a valuable tool in chemical biology for developing novel therapeutic strategies by enabling the creation of bifunctional compounds that can modulate protein interactions. -
PROTAC Linkers
DBCO-NHCO-PEG2-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO (dibenzocyclooctyne) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted degradation of specific proteins, enhancing research in pharmacology and therapeutic discovery.
