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DBCO-PEG4-VA-PABC-MMAE

Catalog No.: A41440
Drug-Linker Conjugate for ADC
DBCO-PEG4-VA-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It features a potent tubulin inhibitor, MMAE, linked via a cleavable moiety, DBCO-PEG4-VA-PABC, facilitating targeted delivery to cancer cells. This conjugate is suitable for the synthesis of ADCs, demonstrating potential application in targeted cancer therapies by enhancing therapeutic efficacy while minimizing systemic toxicity.
DBCO-PEG4-VA-PABC-MMAE 3049211-57-3 Drug-Linker Conjugate for ADC
Grouped product items
Size Price Stock Qty
1mg
$385.00
In stock
5mg
$985.00
In stock
10mg
$1,680.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDBCO-PEG4-VA-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It features a potent tubulin inhibitor, MMAE, linked via a cleavable moiety, DBCO-PEG4-VA-PABC, facilitating targeted delivery to cancer cells. This conjugate is suitable for the synthesis of ADCs, demonstrating potential application in targeted cancer therapies by enhancing therapeutic efficacy while minimizing systemic toxicity.
Product Information
Catalog NumA41440
FormulaC85H122N10O18
Molecular Weight1571.93
CAS Number3049211-57-3
SMILESO=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCNC(CCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)=O)=O)=O)=O)=O)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC
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