BG-DBCO

Catalog No.: A44366
BG-JQ1 Intermediate
BG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways.
Product Information
Catalog NumA44366
FormulaC32H27N7O3
Molecular Weight557.60
CAS Number1820756-74-8
SMILESNC1=NC2=C(C(OCC3=CC=C(C=C3)CNC(CCC(N4CC5=C(C#CC6=CC=CC=C46)C=CC=C5)=O)=O)=N1)N=CN2
SynonymsSNAP-DBCO
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