DBCO

DSPE-PEG-DBCO ammonium is a biochemical reagent that facilitates copper-free click chemistry via strain-promoted alkyne-azide cycloaddition (SPAAC) with azido-functionalized peptide ligands. This compound is pivotal in drug delivery and nanoparticle research, enabling precise biomolecule conjugation and enhancing therapeutic efficacy. Its unique properties make it suitable for various applications in bioconjugation and nanomedicine.

DBCO-PEG12-acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of Proteolysis Targeting Chimera (PROTAC) molecules. Featuring a DBCO ( dibenzocyclooctyne) moiety, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is integral for developing novel bifunctional agents aimed at targeted protein degradation, enhancing research in pharmacology and therapeutic applications.

DBCO-PEG2-PFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enhancing the efficiency of target protein degradation. Its application in PROTAC development makes it a valuable tool for researchers exploring regulated protein degradation pathways in cellular studies.

DBCO-PEG2-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-NH-Boc facilitates the construction of complex bioconjugates, making it a valuable tool for targeted protein degradation studies in chemical biology and drug discovery.

DBCO-NHCO-PEG5-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties make it suitable for applications in targeted protein degradation research and the development of novel therapeutic strategies.

DBCO-NH-(CH2)4COOH is a Proximity-Activated Linker (PROTAC) that facilitates targeted protein degradation by linking target proteins to E3 ligases. This compound features a DBCO functional group, which enables efficient reaction through strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use in PROTAC synthesis supports research in protein modulation and therapeutic development, providing a versatile tool for advancing insights in cellular biology and drug discovery.

DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.

DBCO-HS-PEG2-VA-PABC-SG3199 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a SG3199-based DNA small channel crosslinker combined with a cleavable linker, facilitating targeted delivery of therapeutic agents. This reagent is suitable for the synthesis of ADCs, enabling enhanced efficacy in drug-based cancer therapies and other biomedical research applications.

Methyltetrazine-PEG2-DBCO is a water-soluble reagent designed for efficient bioconjugation through the copper-free Click Chemistry mechanism. Featuring a DBCO moiety linked by a PEG spacer, this compound facilitates the conversion of azido-tagged peptides or proteins into tetrazine-functionalized derivatives without the need for catalysts or auxiliary reagents. Its key biological activity enhances the versatility of biochemical assays and is particularly valuable in the fields of proteomics and materials science.

m-PEG2-DBCO is a monodisperse polyethylene glycol (PEG) reagent that facilitates copper-free click chemistry. It enables the efficient reaction between dibenzocyclooctyne (DBCO) and azide-containing compounds, making it a valuable tool for bioconjugation applications. This reagent is particularly useful in biochemical assays and labeling techniques where selective and efficient conjugation is required.

BP Fluor 546 DBCO is an azide-reactive probe designed for imaging azide-tagged biomolecules through a copper-free click reaction. This reagent offers a stable triazole formation without the need for copper catalysts or elevated temperatures, making it suitable for applications sensitive to copper. The water-soluble, orange-fluorescent dye exhibits absorption and emission maxima at 554 nm and 570 nm, respectively, and is compatible with 488 nm and 532 nm laser lines. BP Fluor 546 DBCO can be conjugated to various biomolecules, including antibodies, peptides, and proteins, facilitating reliable signal generation in imaging and flow cytometry.

Methyltetrazine-PEG4-DBCO is a versatile biochemical assay reagent featuring a PEG linker, a terminal TCO reactive moiety, and a DBCO group. The DBCO component facilitates copper-free Click Chemistry reactions, enabling efficient bioconjugation. This reagent is ideal for converting azido-containing peptides or proteins into tetrazine-modified counterparts without the need for catalysts or auxiliary reagents, making it a valuable tool for researchers in biochemistry and protein engineering.

DBCO-N-bis(PEG4-acid) is a branched click chemistry reagent featuring a DBCO group that facilitates copper-free Click Chemistry reactions. Its carboxylic acid functionalities enable efficient coupling with primary amines, utilizing activators such as EDC or HATU to form stable amide bonds. This reagent is ideal for biochemical assays and applications requiring bioconjugation, contributing to the development of diverse biomolecular constructs.

Methyltetrazine-PEG11-DBCO is a TCO-reactive reagent featuring a DBCO group and a hydrophilic PEG spacer. This compound enables the efficient conversion of azide-containing peptides or proteins into tetrazine-modified analogs without the need for catalysts or auxiliary reagents. The DBCO moiety is particularly beneficial for facilitating copper-free Click Chemistry reactions, making this reagent valuable for biochemical assays and labeling applications in chemical biology and therapeutic research.

DBCO-PEG6-NH-Boc is a biochemical assay reagent featuring a dibenzocyclooctyne (DBCO) functional group attached to a Boc-protected amine via a polyethylene glycol (PEG) linker. The DBCO group enables efficient copper-free click chemistry reactions with azides, facilitating bioconjugation in a range of biological contexts. The hydrophilic PEG linker enhances the compound’s water solubility, making it suitable for diverse applications in biomolecular research and drug development. The Boc protecting group can be easily removed under acidic conditions, allowing for versatile modifications in experimental setups.

Paclitaxel-DBCO is a derivative of Paclitaxel, modified to include a dibenzocyclooctyne (DBCO) linker. This modification enhances its conjugation capabilities, making it suitable for targeted drug delivery applications. Paclitaxel-DBCO retains the cytotoxic properties of the parent compound, thereby facilitating research on its efficacy in cancer therapeutics and nanoparticle formulation studies. It serves as a valuable tool for bioconjugation and drug development in cancer research.

ICG-DBCO is a near-infrared fluorescent dye targeting biological imaging applications. Its fluorescence emits at 813 nm upon excitation at 789 nm, making it suitable for labeling cells, biomolecules, and particles. This compound is essential for various research applications, including in vivo imaging and fluorescence microscopy, allowing for enhanced visualization of biological processes.

FAM DBCO, 6-isomer is a fluorescent dye that incorporates a terminal dibenzocyclooctyne (DBCO) group, allowing for copper-free Click Chemistry applications. This compound exhibits high reactivity due to its strained structure, facilitating the efficient formation of covalent bonds in bioconjugation reactions. FAM DBCO can be utilized in a variety of biological applications, including cell labeling, tracking, and imaging studies.

BP Fluor 488 DBCO is a fluorescent dye designed for use in copper-free Click Chemistry reactions, specifically targeting azide-containing biomolecules such as antibodies, proteins, and peptides. It exhibits strong fluorescent properties, with an excitation peak at 499 nm and an emission peak at 520 nm, making it suitable for applications in microscopy and flow cytometry. This dye is derived from a pure 5-sulfonated rhodamine molecule, ensuring consistent performance and minimizing lot-to-lot variability caused by isomer ratio differences.

Cyanine 5.5 DBCO chloride is a versatile click chemistry reagent featuring a cycloalkyne moiety that enables efficient, copper-free bioconjugation. This compound serves as a linker for the Cyanine 5.5 fluorophore, providing excellent stability and fast reaction kinetics. With excitation and emission wavelengths of 680 nm and 715 nm, respectively, it is ideal for applications in fluorescent imaging and labeling of lipids and biomolecules in various biological research contexts.

Cyanine 7 DBCO chloride is a fluorescent lipid reagent featuring a dibenzocyclooctyne (DBCO) group that facilitates copper-free click chemistry. This compound exhibits superior biocompatibility, rapid reaction kinetics, and stability, with an excitation/emission wavelength of 745/785 nm. It is primarily utilized in biological research for fluorescent labeling and imaging applications, enabling detailed visualization of cellular structures and processes.

Cyanine 3 DBCO chloride is a fluorescent lipid labeling reagent that incorporates a cycloalkyne group for click chemistry applications. This compound features a DBCO moiety, facilitating copper-free biocompatible click reactions with rapid kinetics and excellent stability. With excitation and emission wavelengths of 550 nm and 570 nm respectively, it is ideal for labeling and visualizing biomolecules in various biological research applications, including tracking cellular processes and studying lipid interactions.

MB 543 DBCO is a fluorescent dye featuring a terminal DBCO group, which enables its application in copper-free Click Chemistry reactions through strain-promoted cycloaddition. This highly hydrophilic, water-soluble compound exhibits strong orange fluorescence with a maximum absorption at 543 nm and emission at 566 nm. Additionally, MB 543 DBCO demonstrates excellent stability across a broad pH range from 3 to 10, making it suitable for various biological imaging and labeling applications in research.

MB 660R DBCO is a far-red fluorescent dye, exhibiting strong fluorescence emission at approximately 685 nm. With an absorption maximum at around 665 nm, it can be effectively excited using 633 or 635 nm lasers. This dye is characterized by high water solubility and maintains stability across a broad pH range from 4 to 10. Its robust photostability and brightness make MB 660R DBCO suitable for various applications in fluorescent imaging and labeling in biological research.

BP Fluor 405 DBCO is a blue-fluorescent dye that utilizes copper-free click chemistry for targeted labeling of azides, resulting in stable triazole formation. Its excitation wavelength is optimal for use with the 407 nm spectral line of the krypton laser or the 408 nm violet laser diode. This dye is particularly useful in multi-color applications such as flow cytometry and super-resolution microscopy techniques like STORM, enabling precise visualization in complex biological samples.

Tetra-sulfo-Cy7 DBCO is a highly fluorescent near-infrared dye designed for applications requiring low background noise and high sensitivity. This water-soluble, hydrophilic probe exhibits remarkable photostability and maintains consistent fluorescence across a pH range of 4 to 10, minimizing autofluorescence interference in biological samples. Tetra-sulfo-Cy7 DBCO is ideal for use in various imaging techniques, where its long-wavelength emission is optimized for detection by advanced imaging systems.

BP Fluor 430 DBCO is a fluorescent dye that reacts with azides through a copper-free click chemistry mechanism, resulting in stable triazole formations without the need for copper catalysts or elevated temperatures. This dye exhibits bright, photostable green fluorescence, with optimal excitation at 432 nm and an emission peak at 539 nm, remaining pH independent across a broad pH range. BP Fluor 430 DBCO is suitable for various labeling applications in bioimaging and bioconjugation, although it is not recommended for staining intracellular components of fixed and permeabilized cells due to potential high background fluorescence.

DBCO-PEG2-OH is a functionalized polyethylene glycol (PEG) derivative designed for the selective labeling of azide-modified biomolecules through a click chemistry mechanism. This compound facilitates bioconjugation and is widely utilized in the development of drug carriers and in protein labeling applications. Its versatility makes it an important tool in biochemistry and chemical biology research.