Catalog No.
Product Name
Application
Product Information
Citations
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Anti-Inflammatory Agent
9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs) that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting cytokine production, particularly reducing the expression of IL-1β and IL-6. This compound is relevant for research into inflammatory pathways and potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Lipoxin B4 (LXB4) is an anti-inflammatory agent derived from the metabolism of arachidonic acid. It effectively reduces leukocyte infiltration and mucus secretion in the nasal mucosa while inhibiting mast cell and eosinophil degranulation in the upper airway. Additionally, LXB4 mitigates airway inflammation, mucus metaplasia, and hyper-responsiveness in the lower airway, demonstrating significant mucosal protective actions. Its properties make it a valuable tool for research into allergic inflammation in the upper and lower respiratory tracts. -
PGE2 Product
13,14-Dihydro-15-keto-prostaglandin A2 is a derivative of 13,14-dihydro-15-keto PGE2, resulting from the non-enzymatic dehydration process. This compound is primarily involved in the metabolic pathway leading to the formation of bicyclo PGE2, which serves as a critical biomarker for PGE2 synthesis. Its significant role in prostaglandin metabolism makes it valuable for research in inflammation, pain, and various physiological processes associated with prostaglandins. -
Anti-inflammatory Agent
17(R)-Resolvin D1 methyl ester serves as a potent anti-inflammatory agent, derived from Aspirin-induced Resolvin D1. This compound is known to regulate the transendothelial migration of human polymorphonuclear leukocytes, displaying significant efficacy with an EC50 of approximately 30 nM for inhibiting neutrophil migration. Its stability as the 17R-trihydroxy-4Z form enhances its utility in inflammation research and therapeutic applications. -
PGE1 Metabolite
13,14-Dihydro PGE1 is a significant metabolite of Prostaglandin E1 (PGE1) that functions as a potent inhibitor of ADP-induced platelet aggregation, with an ID50 of 10.8 ng/mL in platelet-rich plasma. This compound is primarily utilized in research regarding cardiovascular health and platelet function. Its mechanism of action makes it valuable for studies focused on thrombotic disorders and the modulation of vascular responses. -
Non-Steroidal Antiinflammatory Agent
Diflumidone sodium is a non-steroidal anti-inflammatory agent that primarily targets the COX enzyme pathway. This compound exhibits potent anti-inflammatory activity and is utilized in various research applications aimed at understanding inflammatory processes and developing therapeutic strategies for inflammatory diseases. Its ability to modulate inflammation makes it a valuable tool in pharmacological studies and drug development. -
Anti-inflammatory Agent
Tixocortol pivalate is a corticosteroid that functions primarily as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it useful in the research of inflammatory conditions and disorders. This compound is typically employed in studies aimed at understanding the mechanisms of corticosteroids in therapeutic applications. -
Nrf2 Pathway Activator
Pyrraline is an Nrf2 pathway activator that enhances antioxidant defenses and mitigates inflammation. It promotes the upregulation of antioxidant enzymes, including NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1), through the activation of the antioxidant response element (ARE), while also inhibiting NFκB-mediated inflammatory pathways. This compound holds significant potential for investigations into metabolic disorders, such as diabetic nephropathy, as well as various cancer research applications. -
Endogenous Metabolite
p60 (217–225) is a subdominant epitope derived from Listeria monocytogenes, recognized by H-2Kd MHC class I molecules. This peptide plays a crucial role in the immune response to Listeria infection, facilitating T cell recognition and activation. p60 (217–225) is essential for studying antigen presentation and T cell immunity in infectious disease research and vaccine development. -
Endogenous Metabolite
9(R)-HODE is a monohydroxy fatty acid and an endogenous metabolite of linoleic acid, generated through the enzymatic actions of cyclooxygenase (COX) and lipoxygenase (LO). This compound is known to promote chemotaxis and elevate the expression of chemokine receptors CCR9 and CXCR4 in immune cells. Additionally, 9(R)-HODE effectively inhibits interleukin-6 (IL-6) release in primary human monocytes and suppresses CD3α- and CD28-induced proliferation in isolated human peripheral blood lymphocytes at a concentration of 25 μg/mL, making it a valuable tool for studying immune responses and inflammatory processes. -
Anti-Inflammatory Agent
3-Aminoisobutyric acid sodium salt acts as an anti-inflammatory agent through its antioxidant properties. It enhances the expression of brown adipocyte-specific genes within white adipose tissue and promotes fatty acid β-oxidation in hepatocytes. This compound has been shown to mitigate insulin resistance and inflammation triggered by palmitate or high-fat diets via an AMPK–PPARδ-dependent pathway in murine models. Additionally, 3-Aminoisobutyric acid sodium salt is a catabolic metabolite of thymine and valine in skeletal muscle. -
PROTAC IKZF1/IKZF3 Degrader
(Rac)-Cemsidomide is a PROTAC degrader targeting IKZF1 and IKZF3, exhibiting potent antitumor activity through its molecular glue mechanism. This compound demonstrates a GI50 of 0.05 nM in NCIH929.1 cells, making it a valuable tool for research applications focused on the degradation of Ikaros and Aiolos proteins. Its unique properties facilitate investigations into mechanisms of action related to targeted protein degradation in cancer therapies. -
Molecular Glue
Acetyl-cyclosporin A aldehyde is a derivative of Cyclosporin A featuring an acetyl group and a reducing aldehyde moiety. This compound serves as a molecular glue by effectively inhibiting calmodulin and binding to cyclophilin, which can influence the nuclear translocation of NF-AT and may lead to mitochondrial damage. Its unique properties make it valuable for research applications aimed at understanding calcium signaling pathways and mitochondrial dynamics in various biological contexts. -
Covalent Ligand
EN171 is a covalent ligand that selectively modifies cysteine residues C38 and C96 on the 14-3-3 protein, thereby promoting its interactions with estrogen receptor α (ERα), YAP, and TAZ. This modulation leads to a reduction in transcriptional activity associated with both estrogen signaling and the Hippo pathway. EN171 serves as a molecular glue, enhancing native protein interactions, and acts as a covalent recruiter of 14-3-3 in heterobifunctional applications, facilitating the cytosolic sequestering of nuclear neo-substrates such as BRD4 and BCL6. -
PROTAC Linker
tert-Butyl 6-aminocaproate is a PROTAC linker that facilitates the development of targeted protein degraders. This compound plays a crucial role in the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling selective degradation of target proteins. Its utility in chemical research supports the exploration of innovative therapeutic strategies through targeted protein modulation. -
Anti-inflammatory Agent
Linalyl acetate is a phytochemical compound that primarily functions as an anti-inflammatory agent. It exhibits a range of biological activities including anti-anxiety and cardioprotective effects. This compound is useful in research focusing on inflammatory responses and offers potential applications in developing therapeutic agents for related conditions. Linalyl acetate's oral bioactivity further enhances its relevance in pharmacological studies. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-7 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.45 µM. This compound plays a crucial role in modulating the Nrf2 signaling pathway, which is essential for cellular responses to oxidative stress. Its application is significant in studies focused on neuroprotection, cancer therapy, and various diseases associated with oxidative damage. -
Nrf2 Peptide
Nrf2 (69-84) is a peptide derived from the Nrf2 protein, featuring the essential ETGE motif critical for binding to the Kelch domain of the Keap1 protein. This peptide serves as a valuable tool for investigating the regulatory functions of Nrf2 in various biological processes, particularly in the context of cancer, neurodegenerative disorders, and inflammatory diseases. Its application aids in elucidating the mechanisms by which Nrf2 modulates cellular responses to oxidative stress and inflammation. -
Nrf2 Activator
Nrf2-Activator-12G is a potent activator of Nrf2, a critical transcription factor involved in cellular antioxidant defense mechanisms. This compound effectively induces the expression of Nrf2-dependent antioxidant enzymes at the mRNA and protein levels in dopaminergic neuronal cells. Nrf2-Activator-12G is applicable in research related to Parkinson's Disease, facilitating studies on oxidative stress and neuroprotection. -
Nrf2/ARE Pathway Activator
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that serves as an activator of the Nrf2/ARE signaling pathway. This compound demonstrates significant antioxidant properties, alleviating oxidative stress and improving insulin resistance. Its role in enhancing cellular defense mechanisms makes it valuable for research in metabolic disorders and oxidative stress-related conditions. -
Keap1-Nrf2 Activator
Dimethyl fumarate-d6 is a deuterium-labeled derivative of Dimethyl fumarate, functioning as a Keap1-Nrf2 pathway activator. This compound enhances the expression of antioxidant genes by stimulating the Nrf2 signaling pathway, thereby providing potential protective effects against oxidative stress. It is useful in research focused on oxidative stress, inflammation, and cellular response mechanisms. -
Anti-inflammatory Drug
Sanggenon A is an anti-inflammatory compound that modulates the NF-κB and HO-1/Nrf2 signaling pathways, demonstrating significant effects in BV2 and RAW264.7 cells. This reagent effectively inhibits the lipopolysaccharide (LPS)-induced production of nitric oxide, making it a valuable tool for research into inflammatory processes and potential therapeutic applications in inflammation-related diseases. -
Anticancer Agent
Tigloylgomisin H is a lignan that targets the induction of quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. This compound functions as a monofunctional inducer, specifically enhancing the expression of the phase II detoxification enzyme NQO1 via the NF-E2-related factor 2 (Nrf2)-ARE pathway. As a result, Tigloylgomisin H demonstrates potential as a preventive agent against liver cancer, making it valuable for cancer research applications. -
Keap1-Nrf2 Activator
LMDP10 is an orally active 3-amino quinazoline derivative that functions as a Keap1-Nrf2 activator. By binding to Keap1, LMDP10 disrupts the Keap1-Nrf2 interaction, leading to the activation of the Nrf2 pathway. This compound enhances the levels of Nrf2, superoxide dismutase (SOD), and glutathione (GSH), while decreasing malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) levels. LMDP10 exhibits potential in mitigating neurodegeneration and improving cognitive function in models of Alzheimer's disease, making it a valuable tool for research in neurodegenerative disorders. -
Bioactive Peptide
Keap1-Nrf2-IN-16 is a bioactive peptide that targets the KEAP1 protein to disrupt its interaction with the Nrf2 transcription factor. This inhibition leads to the stabilization and activation of Nrf2, promoting the expression of antioxidant response elements and enhancing cellular defense mechanisms. Keap1-Nrf2-IN-16 is utilized in research applications related to oxidative stress, cellular protection, and neurodegenerative diseases. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-23 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, exhibiting an IC50 of 16.0 nM. It demonstrates strong binding affinity to Keap1 with a Kd value of 3.07 nM, making it a valuable tool for research into antioxidant response pathways. This compound is suitable for studies related to cellular defense mechanisms and may have applications in the field of cancer research and neurodegenerative diseases. -
Ligand for Target Protein for PROTAC
Nrf2 activator-22 is a ligand specifically targeting the Nrf2 protein, playing a crucial role in the development of PROTAC-based therapeutics. This compound facilitates the synthesis of PROTAC K-Ras Degrader-7, highlighting its potential in targeted protein degradation research. Nrf2 activator-22 is valuable for studies aimed at manipulating oxidative stress responses and related signaling pathways. -
Nrf2 Activator
Nrf2 activator-5 is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This compound effectively reduces hydrogen peroxide-induced oxidative stress and lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells. Nrf2 activator-5 demonstrates significant antioxidant and anti-inflammatory properties, making it valuable for research into neuroinflammation and oxidative stress. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-3 is a selective inhibitor targeting the KEAP1-NRF2 protein-protein interaction, demonstrating a Kd value of 2.5 nM for KEAP1. This compound enhances NRF2 activity, leading to elevated expression of antioxidant response genes. It is valuable for research applications focused on oxidative stress, cancer biology, and neuroprotection, providing insights into mechanisms influencing cellular defense pathways. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-28 is a potent inhibitor of the Keap1-Nrf2 signaling pathway. This compound exhibits significant antioxidant activity by promoting the upregulation of Nrf2 and its downstream targets, including HO-1, GCLM, and Akr1c1. Additionally, Keap1-Nrf2-IN-28 has been shown to mitigate acute liver injury induced by acetaminophen, making it a valuable tool in research related to oxidative stress and liver protection. -
Nrf2 Activator
Fraxinellone analog 1 is a potent Nrf2 activator that enhances the antioxidant defense system and protects against glutamate-mediated excitotoxicity. This compound induces the expression of key antioxidant genes, including Gpx4, Sod1, and Nqo1, demonstrating neuroprotective effects and regulatory capabilities against oxidative stress and inflammation. Fraxinellone analog 1 is valuable for research applications focused on neurodegenerative diseases and related oxidative stress models. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-5 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), with an IC50 of 4.1 µM and a Kd of 3.7 µM. This compound enhances Nrf2 activity, promoting the expression of antioxidant and cytoprotective genes. It serves as a valuable tool for research into oxidative stress, neuroprotection, and cancer therapeutics. -
Nrf2 Activator
Nrf2 activator 17 is a potent activator of the Nrf2 signaling pathway, functioning by inhibiting the interaction between Keap1 and Nrf2 with an IC50 of less than 0.1 pM. This compound demonstrates significant biological activity, exhibiting an EC50 of less than 10 µM in HepG2 cells. Nrf2 activator 17 is utilized in research applications focused on oxidative stress, cellular protection, and the study of Nrf2-related pathways in various disease models. -
Nrf2 Activator
Nrf2 activator-20 is a potent Nrf2 activator that enhances anti-inflammatory and antioxidant responses by disrupting the Keap1-Nrf2 interaction. It has demonstrated beneficial effects in vivo, making it suitable for research applications involving acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury. This reagent serves as a valuable tool for studying the modulation of oxidative stress and inflammation pathways in various biological contexts. -
Nrf2 Activator
R079 is a selective, orally active Nrf2 activator that enhances Nrf2 translocation with an EC50 of 32.41 μM. By activating Nrf2, R079 effectively neutralizes excess reactive oxygen species, contributing to its anti-inflammatory properties. This compound serves as a valuable tool for research into oxidative stress and inflammatory conditions, including multiple sclerosis. -
Keap1-Nrf2 Probe
Keap1-Nrf2 Probe is designed to selectively bind to the Kelch-like ECH-associated protein 1 (Keap1), modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. By inhibiting Keap1 function, this probe enhances the transcription of antioxidant response elements, promoting cellular defense against oxidative stress. It is valuable for research on oxidative stress-related diseases, drug discovery targeting the Nrf2 pathway, and studying cellular mechanisms involved in stress responses. -
Nrf2 Activator
Rosolic acid is a potent activator of Nrf2, leading to the upregulation of its downstream targets. This compound has been shown to enhance levels of angiogenic factors while reducing inflammation markers such as TNF-α and IL-1β, as well as apoptotic markers like CXCL10 and CCL2. Additionally, rosolic acid aids in restoring pancreatic cell function and offers protective effects on endothelial cells against endoplasmic reticulum stress. Its applications include studies on oxidative stress, inflammation modulation, and cellular protection mechanisms. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-8 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, demonstrating IC50 values of 64.5 nM and 14.2 nM in fluorescence polarization and time-resolved fluorescence resonance energy transfer assays, respectively. This compound effectively enhances the mRNA expression of key Nrf2 target genes, including GSTM3, HMOX2, and NQO1. Keap1-Nrf2-IN-8 is instrumental in research focused on oxidative stress response and cellular defense mechanisms. -
Nrf2 Activator
2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative that functions as a potent activator of the Nrf2 pathway. This compound promotes the expression of antioxidant proteins and plays a crucial role in cellular protection against oxidative stress. It is particularly relevant for research applications focused on diseases linked to oxidative stress and inflammation. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-15 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, exhibiting IC50 values of 77 nM in fluorescence polarization (FP) assays and 2.5 nM in time-resolved Förster resonance energy transfer (TR-FRET) assays. This compound enhances the activation of the Nrf2 pathway, which plays a critical role in cellular defense mechanisms against oxidative stress and inflammation. Keap1-Nrf2-IN-15 is a valuable tool for research applications focused on neuroprotection, cancer therapy, and the modulation of antioxidant responses. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-12 is a potent inhibitor of the Keap1-Nrf2 interaction, exhibiting an IC50 value of 2.30 µM. This compound effectively modulates the Nrf2 signaling pathway, which is critical for cellular defense against oxidative stress. Additionally, Keap1-Nrf2-IN-12 demonstrates metabolic stability in human liver microsomes, making it a valuable tool for research applications focused on oxidative stress response and related therapeutic targets. -
Flavone Glycoside
Carlinoside is a flavone glycoside that exhibits hepatoprotective properties. It effectively reduces hepatic bilirubin accumulation by enhancing bilirubin-UDP-glucuronosyltransferase (UGT) activity through the activation of Nrf2 gene expression. This compound holds potential for the management of hyperbilirubinemia associated with liver dysfunction. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-22 is a selective inhibitor of the Keap1-Nrf2 interaction, exhibiting a KD2 value of 42.2 nM for Keap1. This compound is valuable for investigating the regulatory mechanisms of oxidative stress and cytoprotection in cellular environments. Key research applications include the study of acute lung injury (ALI) and cerebral ischemia/reperfusion (I/R) injury, where modulation of the Nrf2 pathway may provide therapeutic insights. -
KEAP1 Inhibitor
Keap1-IN-2 is a potent KEAP1 inhibitor with an IC50 of 2 nM, designed to indirectly activate Nrf2. By inhibiting KEAP1, this compound enhances cellular antioxidant capacity and promotes the accumulation and nuclear translocation of Nrf2, preventing its degradation. Keap1-IN-2 is applicable in research exploring diseases linked to oxidative stress, including inflammatory bowel disease, Crohn's disease, and immune disorders such as ulcerative colitis. -
Nrf-2 Activator
TPNA10168 is an Nrf-2 activator that enhances the Keap1-Nrf2-ARE signaling pathway. It exhibits neuroprotective properties against oxidative stress-induced cellular damage and significantly downregulates the expression of inflammatory genes such as TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 is suitable for research applications focused on anti-inflammatory responses and neurological disorders. -
Antioxidant Agent
WN1316 is an orally active antioxidant agent that exhibits neuroprotective properties. It is primarily utilized in research focused on amyotrophic lateral sclerosis (ALS), making it a valuable tool for studying neurodegenerative diseases and the underlying mechanisms of oxidative stress in neuronal cells. -
Nrf2 Activator
CPDT is a potent activator of the transcription factor Nrf2, which plays a crucial role in cellular defense mechanisms. It significantly induces the expression of phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1, and glutamate cysteine synthetase. Research demonstrates that CPDT enhances glutathione levels in rat bladder in vivo and in cultured bladder cells in vitro, highlighting its potential applications in studies of oxidative stress and antioxidant responses. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-17 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction. This compound enhances the activation of the Nrf2 pathway, which plays a critical role in cellular defense against oxidative stress and inflammation. Keap1-Nrf2-IN-17 is valuable for research applications focused on understanding the mechanisms of oxidative stress response and exploring therapeutic options for related diseases. -
Anti-inflammatory agent
N,N-Dimethylacetamide (DMAc) is an anti-inflammatory agent that primarily inhibits the NF-κB signaling pathway. Its ability to traverse the blood-brain barrier and function as an FDA-approved drug excipient enhances its utility in various research contexts. DMAc is particularly relevant for investigating the mechanisms of weight gain related to high-fat diets and exploring neuroinflammation associated with Alzheimer's disease. -
Anti-Oxidative/Inflammatory Agent
Sulfuretin is a potent anti-oxidative and anti-inflammatory agent that inhibits the NF-κB signaling pathway. It demonstrates efficacy in reducing oxidative stress, platelet aggregation, and mutagenesis, making it relevant for research in allergic airway inflammation. Sulfuretin acts as a competitive inhibitor of monophenolase and diphenolase activities, with an IC50 of 13.64 μM, underscoring its significance in exploring inflammatory responses and oxidative damage in biochemical studies.
