Catalog No.
Product Name
Application
Product Information
Citations
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Nrf2 Activator
Nrf2-Activator-12G is a potent activator of Nrf2, a critical transcription factor involved in cellular antioxidant defense mechanisms. This compound effectively induces the expression of Nrf2-dependent antioxidant enzymes at the mRNA and protein levels in dopaminergic neuronal cells. Nrf2-Activator-12G is applicable in research related to Parkinson's Disease, facilitating studies on oxidative stress and neuroprotection. -
Nrf2/ARE Pathway Activator
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that serves as an activator of the Nrf2/ARE signaling pathway. This compound demonstrates significant antioxidant properties, alleviating oxidative stress and improving insulin resistance. Its role in enhancing cellular defense mechanisms makes it valuable for research in metabolic disorders and oxidative stress-related conditions. -
Keap1-Nrf2 Activator
Dimethyl fumarate-d6 is a deuterium-labeled derivative of Dimethyl fumarate, functioning as a Keap1-Nrf2 pathway activator. This compound enhances the expression of antioxidant genes by stimulating the Nrf2 signaling pathway, thereby providing potential protective effects against oxidative stress. It is useful in research focused on oxidative stress, inflammation, and cellular response mechanisms. -
Anti-inflammatory Drug
Sanggenon A is an anti-inflammatory compound that modulates the NF-κB and HO-1/Nrf2 signaling pathways, demonstrating significant effects in BV2 and RAW264.7 cells. This reagent effectively inhibits the lipopolysaccharide (LPS)-induced production of nitric oxide, making it a valuable tool for research into inflammatory processes and potential therapeutic applications in inflammation-related diseases. -
Anticancer Agent
Tigloylgomisin H is a lignan that targets the induction of quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. This compound functions as a monofunctional inducer, specifically enhancing the expression of the phase II detoxification enzyme NQO1 via the NF-E2-related factor 2 (Nrf2)-ARE pathway. As a result, Tigloylgomisin H demonstrates potential as a preventive agent against liver cancer, making it valuable for cancer research applications. -
Keap1-Nrf2 Activator
LMDP10 is an orally active 3-amino quinazoline derivative that functions as a Keap1-Nrf2 activator. By binding to Keap1, LMDP10 disrupts the Keap1-Nrf2 interaction, leading to the activation of the Nrf2 pathway. This compound enhances the levels of Nrf2, superoxide dismutase (SOD), and glutathione (GSH), while decreasing malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) levels. LMDP10 exhibits potential in mitigating neurodegeneration and improving cognitive function in models of Alzheimer's disease, making it a valuable tool for research in neurodegenerative disorders. -
Bioactive Peptide
Keap1-Nrf2-IN-16 is a bioactive peptide that targets the KEAP1 protein to disrupt its interaction with the Nrf2 transcription factor. This inhibition leads to the stabilization and activation of Nrf2, promoting the expression of antioxidant response elements and enhancing cellular defense mechanisms. Keap1-Nrf2-IN-16 is utilized in research applications related to oxidative stress, cellular protection, and neurodegenerative diseases. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-23 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, exhibiting an IC50 of 16.0 nM. It demonstrates strong binding affinity to Keap1 with a Kd value of 3.07 nM, making it a valuable tool for research into antioxidant response pathways. This compound is suitable for studies related to cellular defense mechanisms and may have applications in the field of cancer research and neurodegenerative diseases. -
Ligand for Target Protein for PROTAC
Nrf2 activator-22 is a ligand specifically targeting the Nrf2 protein, playing a crucial role in the development of PROTAC-based therapeutics. This compound facilitates the synthesis of PROTAC K-Ras Degrader-7, highlighting its potential in targeted protein degradation research. Nrf2 activator-22 is valuable for studies aimed at manipulating oxidative stress responses and related signaling pathways. -
Nrf2 Activator
Nrf2 activator-5 is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. This compound effectively reduces hydrogen peroxide-induced oxidative stress and lipopolysaccharide (LPS)-induced inflammation in BV-2 microglial cells. Nrf2 activator-5 demonstrates significant antioxidant and anti-inflammatory properties, making it valuable for research into neuroinflammation and oxidative stress. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-3 is a selective inhibitor targeting the KEAP1-NRF2 protein-protein interaction, demonstrating a Kd value of 2.5 nM for KEAP1. This compound enhances NRF2 activity, leading to elevated expression of antioxidant response genes. It is valuable for research applications focused on oxidative stress, cancer biology, and neuroprotection, providing insights into mechanisms influencing cellular defense pathways. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-28 is a potent inhibitor of the Keap1-Nrf2 signaling pathway. This compound exhibits significant antioxidant activity by promoting the upregulation of Nrf2 and its downstream targets, including HO-1, GCLM, and Akr1c1. Additionally, Keap1-Nrf2-IN-28 has been shown to mitigate acute liver injury induced by acetaminophen, making it a valuable tool in research related to oxidative stress and liver protection. -
Nrf2 Activator
Fraxinellone analog 1 is a potent Nrf2 activator that enhances the antioxidant defense system and protects against glutamate-mediated excitotoxicity. This compound induces the expression of key antioxidant genes, including Gpx4, Sod1, and Nqo1, demonstrating neuroprotective effects and regulatory capabilities against oxidative stress and inflammation. Fraxinellone analog 1 is valuable for research applications focused on neurodegenerative diseases and related oxidative stress models. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-5 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), with an IC50 of 4.1 µM and a Kd of 3.7 µM. This compound enhances Nrf2 activity, promoting the expression of antioxidant and cytoprotective genes. It serves as a valuable tool for research into oxidative stress, neuroprotection, and cancer therapeutics. -
Nrf2 Activator
Nrf2 activator 17 is a potent activator of the Nrf2 signaling pathway, functioning by inhibiting the interaction between Keap1 and Nrf2 with an IC50 of less than 0.1 pM. This compound demonstrates significant biological activity, exhibiting an EC50 of less than 10 µM in HepG2 cells. Nrf2 activator 17 is utilized in research applications focused on oxidative stress, cellular protection, and the study of Nrf2-related pathways in various disease models. -
Nrf2 Activator
Nrf2 activator-20 is a potent Nrf2 activator that enhances anti-inflammatory and antioxidant responses by disrupting the Keap1-Nrf2 interaction. It has demonstrated beneficial effects in vivo, making it suitable for research applications involving acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury. This reagent serves as a valuable tool for studying the modulation of oxidative stress and inflammation pathways in various biological contexts. -
Nrf2 Activator
R079 is a selective, orally active Nrf2 activator that enhances Nrf2 translocation with an EC50 of 32.41 μM. By activating Nrf2, R079 effectively neutralizes excess reactive oxygen species, contributing to its anti-inflammatory properties. This compound serves as a valuable tool for research into oxidative stress and inflammatory conditions, including multiple sclerosis. -
Keap1-Nrf2 Probe
Keap1-Nrf2 Probe is designed to selectively bind to the Kelch-like ECH-associated protein 1 (Keap1), modulating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. By inhibiting Keap1 function, this probe enhances the transcription of antioxidant response elements, promoting cellular defense against oxidative stress. It is valuable for research on oxidative stress-related diseases, drug discovery targeting the Nrf2 pathway, and studying cellular mechanisms involved in stress responses. -
Nrf2 Activator
Rosolic acid is a potent activator of Nrf2, leading to the upregulation of its downstream targets. This compound has been shown to enhance levels of angiogenic factors while reducing inflammation markers such as TNF-α and IL-1β, as well as apoptotic markers like CXCL10 and CCL2. Additionally, rosolic acid aids in restoring pancreatic cell function and offers protective effects on endothelial cells against endoplasmic reticulum stress. Its applications include studies on oxidative stress, inflammation modulation, and cellular protection mechanisms. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-8 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, demonstrating IC50 values of 64.5 nM and 14.2 nM in fluorescence polarization and time-resolved fluorescence resonance energy transfer assays, respectively. This compound effectively enhances the mRNA expression of key Nrf2 target genes, including GSTM3, HMOX2, and NQO1. Keap1-Nrf2-IN-8 is instrumental in research focused on oxidative stress response and cellular defense mechanisms. -
Nrf2 Activator
2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative that functions as a potent activator of the Nrf2 pathway. This compound promotes the expression of antioxidant proteins and plays a crucial role in cellular protection against oxidative stress. It is particularly relevant for research applications focused on diseases linked to oxidative stress and inflammation. -
Keap1-Nrf2 PPI Inhibitor
Keap1-Nrf2-IN-15 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, exhibiting IC50 values of 77 nM in fluorescence polarization (FP) assays and 2.5 nM in time-resolved Förster resonance energy transfer (TR-FRET) assays. This compound enhances the activation of the Nrf2 pathway, which plays a critical role in cellular defense mechanisms against oxidative stress and inflammation. Keap1-Nrf2-IN-15 is a valuable tool for research applications focused on neuroprotection, cancer therapy, and the modulation of antioxidant responses. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-12 is a potent inhibitor of the Keap1-Nrf2 interaction, exhibiting an IC50 value of 2.30 µM. This compound effectively modulates the Nrf2 signaling pathway, which is critical for cellular defense against oxidative stress. Additionally, Keap1-Nrf2-IN-12 demonstrates metabolic stability in human liver microsomes, making it a valuable tool for research applications focused on oxidative stress response and related therapeutic targets. -
Flavone Glycoside
Carlinoside is a flavone glycoside that exhibits hepatoprotective properties. It effectively reduces hepatic bilirubin accumulation by enhancing bilirubin-UDP-glucuronosyltransferase (UGT) activity through the activation of Nrf2 gene expression. This compound holds potential for the management of hyperbilirubinemia associated with liver dysfunction. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-22 is a selective inhibitor of the Keap1-Nrf2 interaction, exhibiting a KD2 value of 42.2 nM for Keap1. This compound is valuable for investigating the regulatory mechanisms of oxidative stress and cytoprotection in cellular environments. Key research applications include the study of acute lung injury (ALI) and cerebral ischemia/reperfusion (I/R) injury, where modulation of the Nrf2 pathway may provide therapeutic insights. -
KEAP1 Inhibitor
Keap1-IN-2 is a potent KEAP1 inhibitor with an IC50 of 2 nM, designed to indirectly activate Nrf2. By inhibiting KEAP1, this compound enhances cellular antioxidant capacity and promotes the accumulation and nuclear translocation of Nrf2, preventing its degradation. Keap1-IN-2 is applicable in research exploring diseases linked to oxidative stress, including inflammatory bowel disease, Crohn's disease, and immune disorders such as ulcerative colitis. -
Nrf-2 Activator
TPNA10168 is an Nrf-2 activator that enhances the Keap1-Nrf2-ARE signaling pathway. It exhibits neuroprotective properties against oxidative stress-induced cellular damage and significantly downregulates the expression of inflammatory genes such as TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 is suitable for research applications focused on anti-inflammatory responses and neurological disorders. -
Antioxidant Agent
WN1316 is an orally active antioxidant agent that exhibits neuroprotective properties. It is primarily utilized in research focused on amyotrophic lateral sclerosis (ALS), making it a valuable tool for studying neurodegenerative diseases and the underlying mechanisms of oxidative stress in neuronal cells. -
Nrf2 Activator
CPDT is a potent activator of the transcription factor Nrf2, which plays a crucial role in cellular defense mechanisms. It significantly induces the expression of phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1, and glutamate cysteine synthetase. Research demonstrates that CPDT enhances glutathione levels in rat bladder in vivo and in cultured bladder cells in vitro, highlighting its potential applications in studies of oxidative stress and antioxidant responses. -
Keap1-Nrf2 Inhibitor
Keap1-Nrf2-IN-17 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction. This compound enhances the activation of the Nrf2 pathway, which plays a critical role in cellular defense against oxidative stress and inflammation. Keap1-Nrf2-IN-17 is valuable for research applications focused on understanding the mechanisms of oxidative stress response and exploring therapeutic options for related diseases. -
Anti-inflammatory agent
N,N-Dimethylacetamide (DMAc) is an anti-inflammatory agent that primarily inhibits the NF-κB signaling pathway. Its ability to traverse the blood-brain barrier and function as an FDA-approved drug excipient enhances its utility in various research contexts. DMAc is particularly relevant for investigating the mechanisms of weight gain related to high-fat diets and exploring neuroinflammation associated with Alzheimer's disease. -
Anti-Oxidative/Inflammatory Agent
Sulfuretin is a potent anti-oxidative and anti-inflammatory agent that inhibits the NF-κB signaling pathway. It demonstrates efficacy in reducing oxidative stress, platelet aggregation, and mutagenesis, making it relevant for research in allergic airway inflammation. Sulfuretin acts as a competitive inhibitor of monophenolase and diphenolase activities, with an IC50 of 13.64 μM, underscoring its significance in exploring inflammatory responses and oxidative damage in biochemical studies. -
NF-κB Inhibitor
NF-κB-IN-4 is a potent inhibitor of the NF-κB signaling pathway, demonstrating significant blood-brain barrier permeability. This compound exhibits anti-neuroinflammatory activity through its ability to block the phosphorylation and activation of IκBα, thereby reducing NLRP3 expression and inhibiting NF-κB activation. NF-κB-IN-4 is suitable for research applications related to neuroinflammatory diseases, providing a valuable tool for therapeutic investigations. -
Anti-inflammatory Agent
Anti-inflammatory Agent 51 is an amide/sulfonamide derivative that functions primarily as an anti-inflammatory agent. This compound effectively inhibits the activation of NF-κB, making it a valuable tool for research into conditions such as acute lung injury and ulcerative colitis. Its ability to modulate inflammatory pathways positions it as a significant reagent for studying inflammatory diseases and therapeutic interventions. -
Anti-inflammatory Agent
Ageconyflavone B is a flavonoid that functions as an anti-inflammatory agent. It effectively reduces inflammation through the inhibition of IκBα phosphorylation, thereby modulating the NF-κB signaling pathway. This compound is relevant for research applications focused on inflammatory diseases and the underlying molecular mechanisms of inflammation. -
Anti-inflammatory Agent
BS-153 is a synthetic oxazolidinone compound that functions as an anti-inflammatory agent by inhibiting the activation of the NF-κB/PKCθ signaling pathway. It effectively reduces the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6, in LPS-stimulated RAW264.7 macrophage cells. This reagent is suitable for research applications focused on inflammation and immune response modulation. -
Anti-Inflammatory Agent
8α-Hydroxyhirsutinolide is a sesquiterpene lactone that acts as an anti-inflammatory agent by inhibiting TNF-α-induced NF-κB activity with an IC50 of 1.9 μM. Additionally, it reduces nitric oxide production, indicating a potential role in modulating inflammatory pathways. This compound can be isolated from the plant Vernonia cinerea and is useful for research in inflammation and related cellular signaling mechanisms. -
Anti-Inflammatory Agent
Goshonoside F5 is an anti-inflammatory agent derived from the unripe fruits of Rubus chingii. It demonstrates significant anti-inflammatory activity by inhibiting the NF-κB and MAPK signaling pathways. This compound is relevant for research applications focusing on inflammation-related conditions and the underlying molecular mechanisms. -
Anti-inflammatory Agent
Catalposide is an iridoid glycoside derived from Catalpa ovata G. Don (Bignoniaceae) that acts as an anti-inflammatory agent. It effectively inhibits the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as the activation of NF-κB (p65) in lipopolysaccharide-stimulated RAW 264.7 macrophages. This compound is valuable for research in inflammatory pathways and potential therapeutic interventions in inflammatory diseases. -
Anti-Inflammatory Agent
Catalpalactone is an anti-inflammatory agent that functions by inhibiting LPS-induced nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) in RAW264.7 macrophage cells. Additionally, it suppresses the activation of key signaling pathways, including IRF3, NF-κB, and IFN-β/STAT-1. Furthermore, Catalpalactone demonstrates the ability to reduce dopamine biosynthesis through the inhibition of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities, making it valuable for investigations into inflammatory processes and neurochemical pathways. -
Anti-inflammatory Agent
Se-Aspirin is a hybrid compound combining selenium with aspirin, primarily functioning as an anti-inflammatory agent. It exhibits significant biological activity by reducing the viability of various cancer cell lines, with notable efficacy against colorectal cancer cells. This compound is valuable for research applications targeting inflammation-related pathways and cancer therapeutics. -
Anti-neuroinflammatory Agent
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent that targets MAO-B with an IC50 value of 10.30 μM. It demonstrates significant inhibition of Aβ1-42 aggregation, achieving 96.33% reduction at a concentration of 25 μM. Additionally, Neuroinflammatory-IN-2 provides neuroprotective effects in H2O2-induced PC-12 cell injury and exhibits biometal chelating and antioxidant properties. With favorable blood-brain barrier permeability, this compound is suitable for research applications related to Alzheimer’s disease and neuroinflammatory conditions. -
Anti-inflammatory Agent
Manghaslin is a flavonoid glycoside that serves as an anti-inflammatory agent. It exhibits inhibitory activity against acetylcholinesterase (AChE), with an IC50 value of 94.92 μM. This compound is relevant for research into the modulation of inflammation and potential neuroprotective effects. -
BChE Inhibitor
S21-1011 is a selective inhibitor of butyrylcholinesterase (BChE) with IC50 values of 0.059 μM for equine BChE and 0.162 μM for human BChE. This compound demonstrates effective blood-brain barrier permeability and favorable pharmacokinetic properties. Additionally, S21-1011 exhibits anti-inflammatory activity by activating the keap1-Nrf2-ARE signaling pathway, with an EC50 of 23.48 μM for antioxidant response element activation. Its potential to ameliorate cognitive impairments in murine models of Alzheimer’s disease makes it relevant for neurodegenerative research applications. -
AChE/Nrf2 Modulator
AChE/Nrf2 Modulator 1 is an orally active compound that targets both acetylcholinesterase (AChE) and the nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits significant Nrf2 inductive activity along with potent AChE inhibitory effects, presenting IC50 values of 0.07 μM for eel AChE and 0.38 μM for human AChE. This compound is primarily utilized in research focused on Alzheimer's disease, providing insights into neuroprotective mechanisms and cholinergic system modulation. -
Anti-inflammatory Agent
BI-L-45 XX is an orally active anti-inflammatory agent that targets and inhibits the release of neutrophil enzymes as well as chemotaxis. This compound is particularly useful for investigating mechanisms underlying adjuvant-induced arthritis and other inflammatory conditions. Its ability to modulate neutrophil activity makes it a valuable tool in the study of inflammatory pathways. -
TRP-2 Derived Peptide
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide derived from tyrosinase-related protein 2, corresponding to residues 181-188. This peptide contains the primary reactive epitope recognized by anti-B16 cytotoxic T lymphocytes (CTLs) and is designed to conform to the MHC class I H2-Kb binding motif. TRP-2 (181-188) is essential for studies in immunology and cancer research, particularly in the context of melanoma and anti-tumor immune responses. -
Anti-inflammatory agents
2-Hydroxy-4-methoxybenzoic acid potassium primarily functions as an anti-inflammatory agent. As a significant phytoconstituent derived from Decalepis arayalpathra, it exhibits a range of biological activities, including anti-inflammatory, antipyretic, antioxidant, and anti-diabetic effects. This compound is valuable for researchers investigating mechanisms of inflammation and related metabolic disorders. Its diverse pharmacological potential makes it a useful tool in therapeutic studies and drug development. -
Anti-inflammatory Compound
2′-Hydroxydaidzein is an anti-inflammatory compound that acts as a metabolite. It effectively inhibits the release of chemical mediators from inflammatory cells and significantly reduces the secretion of lysozyme and β-glucuronidase from rat neutrophils stimulated with fMLP/CB. This reagent is valuable for research applications related to inflammation and immune response modulation. -
Anti-inflammatory compound
β-Amyrin is a natural triterpenoid compound that exhibits anti-inflammatory properties. It effectively mitigates amyloid β (Aβ)-induced impairments in long-term potentiation (LTP), making it a promising candidate for Alzheimer's disease research. Additionally, β-Amyrin demonstrates protective activity against pulmonary fibrosis and possesses notable antibacterial capabilities, supporting its potential applications in various areas of biological and medicinal research.
