Catalog No.
Product Name
Application
Product Information
Citations
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G6PD Inhibitor
6-Aminonicotinamide is a competitive inhibitor of glucose-6-phosphate dehydrogenase (G6PD) with a Ki value of 0.46 μM. This powerful antimetabolite of nicotinamide induces ATP depletion, enhancing the efficacy of DNA-crosslinking chemotherapy agents such as Cisplatin. Its ability to modulate metabolic pathways makes it a valuable tool in cancer research and therapeutic applications. -
Nox2 Inhibitor
CPP11G is a selective inhibitor of NADPH oxidase 2 (Nox2), exhibiting an IC50 of 20 μM. This compound is valuable for the investigation of inflammatory diseases, such as vasculitis and atherosclerosis, as well as conditions characterized by Nox2 overactivation, including ischemia-reperfusion injury. Its potential applications in research can aid in understanding the role of Nox2 in various pathological processes. -
Nox Inhibitor
VAS2870 is a selective inhibitor of NADPH oxidase (NOX), primarily targeting NOX1 and NOX2 isoforms. This compound exhibits strong antioxidant properties and effectively reduces reactive oxygen species (ROS) production. VAS2870 is widely utilized in research related to oxidative stress, inflammation, and various pathological conditions associated with NOX activity. -
NOX1/4 Inhibitor
GKT136901 is a selective and orally active inhibitor of NADPH oxidases NOX1 and NOX4, exhibiting inhibition constants (Kis) of 160 nM and 165 nM, respectively. This compound also serves as a direct scavenger of peroxynitrite, contributing to its anti-inflammatory properties. GKT136901 is particularly useful in research focused on diabetic nephropathy, stroke, and neurodegenerative diseases, providing valuable insights into oxidative stress-related pathologies. -
Nox1 Inhibitor
NoxA1ds is a selective inhibitor of NADPH oxidase 1 (NOX1), with an IC50 of 20 nM. It effectively inhibits NOX1-derived superoxide production in HT-29 human colon cancer cells. Additionally, NoxA1ds reduces VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro. This reagent is valuable for research into hypertension, atherosclerosis, and cancer biology. -
Nox Inhibitor
NADPH oxidase-IN-1 is an orally active inhibitor of NADPH oxidase (Nox), specifically targeting Nox2 and Nox4 with IC50 values of 1.9 μM and 2.47 μM, respectively. This compound is notable for its ability to penetrate the blood-brain barrier, making it relevant for studies involving neuronal inflammation. NADPH oxidase-IN-1 effectively suppresses the production of pro-inflammatory cytokines and inhibits LPS-mediated microglial migration, demonstrating promising in vivo efficacy for potential therapeutic applications in neuroinflammatory conditions. -
Capsaicinoid Analog
Nordihydrocapsaicin is a capsacinoid analog known for its pungent properties and oral bioactivity. This compound exhibits potential anti-cancer activities and is derived from both fresh and processed peppers. It may induce a burning sensation upon consumption, making it relevant for research in pain mechanisms and anti-tumor effects. -
NOX1/4 Inhibitor
GKT136901 hydrochloride is a highly selective and orally active inhibitor of NADPH oxidase isozymes NOX1 and NOX4, exhibiting inhibition constants of 160 nM and 165 nM, respectively. This compound also functions as a direct scavenger of peroxynitrite, enhancing its therapeutic potential. GKT136901 hydrochloride is primarily utilized in research settings focusing on diabetic nephropathy, stroke, and neurodegenerative diseases, while also demonstrating notable anti-inflammatory properties. -
Nox2/4 Inhibitor
GLX481304 is a selective inhibitor of Nox2 and Nox4, exhibiting an IC50 of 1.25 μM. This compound effectively suppresses reactive oxygen species (ROS) production in isolated mouse cardiomyocytes and enhances cardiac contractility. GLX481304 is applicable in research focused on ischemic heart injury, providing valuable insights into oxidative stress-related pathophysiology. -
NOX1 Inhibitor/ROS Inhibitor
Fluoflavine is a selective inhibitor of NOX1 and reactive oxygen species (ROS) production. This compound effectively reduces ROS levels, NOX1-mediated signaling pathways, and prevents retinal ganglion cell death induced by oxygen-glucose deprivation. In preclinical studies, Fluoflavine has demonstrated the ability to inhibit NADPH oxidase activity and mitigate pathological retinal neovascularization in models of oxygen-induced retinopathy. It is a valuable tool for investigating retinal ischemia-reperfusion injury and proliferative retinopathy. -
NOX2 Inhibitor
NOX2-IN-2 diTFA is a potent inhibitor of NOX2, specifically targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. This compound effectively inhibits reactive oxygen species (ROS) production derived from NOX2 in cellular environments. It is valuable for research applications focused on oxidative stress and related signaling pathways. -
Intermediate
8-Hydroxycoumarin is an important intermediate in the microbial transformation of quinolones. It serves as a valuable building block in organic synthesis and is utilized in research focusing on metabolic pathways of various compounds. Its unique structural properties enable exploration in pharmacology and biochemistry, facilitating the study of enzymatic processes and potential therapeutic agents. -
NADPH Oxidase Inhibitor
NOX2-IN-3 is a selective inhibitor of NADPH Oxidase 2 (NOX2). This compound has been shown to enhance the sensitivity of tumor cells to MRTX1133, indicating its potential role in cancer research. NOX2-IN-3 may be valuable for studies focused on oxidative stress and its implications in tumor biology. -
CBR1 Inhibitor
YF-Mo1 is a selective inhibitor of the carbonyl reductase 1 (CBR1), exhibiting an IC50 value of 1.1 μM. This compound demonstrates potential in modulating CBR1 activity, which is significant in metabolic processes and drug metabolism. YF-Mo1 is valuable for research exploring the role of CBR1 in various physiological and pathological conditions, offering insights into metabolic therapies and drug interactions. -
NOX5 Dehydrogenase Domain Binder
Saikosaponin bk1 is a specific binder for the dehydrogenase domain of NADPH oxidase 5 (NOX5), exhibiting hepatoprotective properties. It forms stable interactions with the NOX5 enzyme derived from Cylindrospermum stagnale, making it a valuable tool in studies of oxidative stress. This compound is particularly relevant in research focused on COVID-19 and alcoholic liver injury, contributing to the understanding of these conditions at a molecular level. -
NQO1 Inhibitor
N-Benzyl-N-demethylpronqodine A is an inhibitor of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), exhibiting an IC50 value of 83.3 nM. This compound plays a significant role in the study of redox biology and the mechanisms of cellular response to oxidative stress. Its application includes investigating the implications of NQO1 inhibition in various disease models, facilitating research in cancer biology and drug metabolism. -
NOX2 Inhibitor
NOX2-IN-2 is a potent inhibitor of NOX2, specifically targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. This compound effectively reduces reactive oxygen species (ROS) production mediated by NOX2 in cellular contexts. NOX2-IN-2 is ideal for research applications focused on oxidative stress, inflammation, and related signaling pathways. -
ALK Inhibitor
TSR-011-isomer is a potent anaplastic lymphoma kinase (ALK) inhibitor with an IC50 of 6 nM. This compound demonstrates significant biological activity by undergoing metabolic hydrolysis and NADPH-dependent metabolism, facilitating its clearance in biological systems. TSR-011-isomer is suitable for research focused on ALK-driven cancers, making it a valuable tool for studies in cancer biology and targeted therapy development. -
CBR1 Inhibitor
CBR1-IN-3 is a potent inhibitor of carbonyl reductase 1 (CBR1), exhibiting an IC50 value of 0.034 μM. This compound serves as a valuable research tool for studies focusing on the modulation of carbonyl metabolites in various biological systems. Its ability to effectively inhibit CBR1 makes it suitable for investigating the enzyme's role in drug metabolism and potential therapeutic applications. -
NADPH Oxidase Inhibitor
Diapocynin, a dimeric derivative of Apocynin, functions as a potent NADPH oxidase inhibitor. This compound exhibits significant anti-inflammatory, neuroprotective, and antioxidant activities, making it valuable for research into oxidative stress, neurodegenerative diseases, and inflammation-related conditions. Its oral bioavailability enhances its utility in various experimental settings aimed at understanding the role of reactive oxygen species in cellular processes. -
NOX2 Inhibitor
NOX2-IN-1 is a selective inhibitor of nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). It effectively disrupts the protein-protein interaction between p47phox and p22phox, demonstrating favorable binding affinities and significant cellular activity. This compound is valuable for research applications focusing on oxidative stress-related diseases and inflammation pathways. -
NOX1 Inhibitor
ML171 analog 1 is a selective inhibitor of NOX1, a member of the NADPH oxidase family implicated in various cellular processes. This compound exhibits significant biological activity in the modulation of reactive oxygen species, making it a valuable tool in cancer research. Its role in inhibiting NOX1 provides insights into oxidative stress related pathways in tumor biology. -
Thrombin Inhibitor
PPACK dihydrochloride is a potent and selective irreversible inhibitor of thrombin. It serves as an alternative anticoagulant to lithium heparin for blood gas and electrolyte analyses in whole blood. Additionally, PPACK dihydrochloride inhibits plasminogen activator (rt-PA), preventing its binding to plasma protease inhibitors. This compound also reduces plasmin-induced endothelial permeability and morphological changes in bovine aortic endothelial cell monolayers, making it suitable for investigations in thrombosis-related research. -
Anti-inflammatory Agent
Fendosal is a potent, orally active non-steroidal anti-inflammatory agent that primarily targets and inhibits Plasminogen activator inhibitor-1 (PAI-1). It demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammatory disease models and therapeutic applications. Its dual action offers insights into conditions mediated by PAI-1, enhancing the understanding of inflammatory pathways and potential treatments. -
PPT1 Inhibitor
Ezurpimtrostat (hydrochloride) is a potent and selective PPT1 inhibitor with multiple biological activities. It disrupts lysosomal function, modulates autophagy, and induces apoptosis, making it a valuable tool in cancer research and immunology. This compound has demonstrated efficacy in reducing inflammatory markers such as IFN-α and CRP, as well as in lowering viral loads of SARS-CoV-2. Ezurpimtrostat is suitable for investigating conditions such as systemic lupus erythematosus, hepatocellular carcinoma, fibrosis, and other related disorders. -
Non-steroidal Antiinflammatory Agent
Protizinic acid is a non-steroidal anti-inflammatory agent that exerts its effects primarily through the inhibition of phospholipase A2 (PLA2) activity, with an IC50 value of 210 μM. This compound exhibits notable anti-inflammatory and antipyretic properties, making it a valuable tool in research focused on inflammatory processes and pain relief mechanisms. It is suitable for studies involving the modulation of inflammatory pathways. -
Anti-inflammatory Agent
BMS-188184 is a type II secretory phospholipase A2 (s-PLA2) inhibitor with an IC50 value of 17 µM. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for studying various inflammatory conditions. It is particularly useful in research aimed at understanding the role of s-PLA2 in mediating inflammatory processes and potential therapeutic interventions. -
FAP Inhibitor
BR102910 is a selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 2 nM. Additionally, BR102910 exhibits inhibition of prolyl oligopeptidase (PREP) with an IC50 of 49.00 μM. This compound is primarily used in research focusing on type 2 diabetes and related metabolic disorders, making it a valuable tool for exploring FAP's role in these conditions. -
Immunoproteasome Activator
Immunoproteasome Activator 1 is a selective activator of the immunoproteasome that enhances the presentation of MHC-I-bound peptides by over 100-fold. This compound functions by binding to the proteasome structural subunit PSMA1, facilitating the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes. Its significant biological activity makes it valuable for research focused on immune response modulation and antigen processing. -
E3 Ligase Ligand
RA190-PEG1-NH2 is an E3 ligase ligand and a derivative of RA190. This compound is utilized in the synthesis of FKBP12 PROTAC degrader RAFKBP12, facilitating targeted protein degradation through the modulation of E3 ligase activity. Its application supports research into the development of proteolysis-targeting chimeras (PROTACs) and advances studies in cellular protein regulation. -
PKM2 Kinase Inhibitor
PKM2-IN-3 is a selective inhibitor of the PKM2 kinase, demonstrating an IC50 value of 4.1 μM. This compound exhibits notable anti-neuroinflammatory effects by disrupting PKM2-mediated glycolysis and inhibiting NLRP3 activation. PKM2-IN-3 is suitable for research applications focused on metabolic regulation and neuroinflammation pathways. -
NRF2 Activator
ML334 is a potent NRF2 activator that functions by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity to the Keap1 Kelch domain of 1 μM, ML334 effectively promotes NRF2 expression and its subsequent nuclear translocation, thereby enhancing antioxidant response element (ARE) activity. This compound is valuable for research applications focused on oxidative stress, neuroprotection, and cellular responses to environmental stimuli. -
Nrf2 Activator
Nrf2 activator-6 is a tetrahydroisoquinoline compound that functions as an activator of the Nrf2 pathway. It exhibits an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction, thereby promoting the transcriptional activation of antioxidant response elements. This compound is valuable in research applications focused on oxidative stress, inflammation, and neuroprotection. -
Nrf2 activator
Nrf2 activator-7 is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. By significantly enhancing Nrf2 signaling, it promotes the expression of antioxidant and cytoprotective genes. This reagent is valuable in research focused on oxidative stress, inflammation, and cellular defense mechanisms. -
PROTAC Linker
(3R,4R)-3-Methyl-4-piperidinol serves as a PROTAC linker, facilitating the targeted degradation of proteins through the proteasome pathway. This compound is essential in the synthesis of innovative PROTAC molecules, such as the BCL6 Degrader-3. Its application in chemical biology aids in studying protein interactions and degradation mechanisms, contributing significantly to drug discovery research. -
FKBP12 Degrader
FKBP12 PROTAC FM4 is a potent PROTAC degrader targeting FKBP12 with demonstrated efficacy in inducing degradation of the MTH1 protein. Its DC50 value ranges from 0.09 to 0.22 nM, effectively inhibiting global protein synthesis and promoting apoptosis in cervical cancer cells that express MTH1-E6 and FKBP12F36V-tagged SARS1. This compound is particularly relevant for research focused on HPV-positive cervical cancer, providing valuable insights into therapeutic strategies against this malignancy. -
AXL Inhibitor
Denfivontinib hydrochloride is an AXL inhibitor that exerts synergistic antitumor effects when used in combination with the PD-1 inhibitor Pembrolizumab. This compound enhances the NOD-like receptor pathway, facilitating the formation of the NLRP3 inflammasome. Its unique mechanism of action makes it a valuable tool for cancer research, particularly in studying immune modulation and tumor progression. -
Anti-Inflammatory Agent
7β-Hydroxy-epi-androsterone primarily targets estrogen receptor beta (ERβ) and exhibits notable anti-inflammatory and neuroprotective activities. As an endogenous androgenic derivative of dehydroepiandrosterone, it is utilized in research to explore its potential therapeutic effects in inflammation-related conditions and neurodegenerative diseases. This compound facilitates investigations into the mechanisms of action involving steroid hormones and their roles in immune and neural functions. -
Anti-inflammatory Agent
Fenclofenac is an orally active anti-inflammatory agent primarily targeting inflammation pathways with a low ulcerogenic effect. This compound also demonstrates antipyretic and analgesic properties, making it valuable in research involving pain and fever. Its safety profile includes an oral LD50 of 2280 mg/kg in rats, supporting its potential for use in inflammation research. -
Tyrosinase Inhibitor, Glutathione Reductase Inhibitor, Dopachrome Tautomerase Cofactor, Melanocortin Receptor 1 and 4 Modulator, Eumelanogenesis Inhibitor, Hair Hypopigmentation Inducer, Hair Cycle Modulator, Antioxidant, Healing Accelerator, Tensile Strength Enhancer, Anti-inflammatory Agent
Zinc sulphate functions primarily as an inhibitor of tyrosinase and glutathione reductase, exhibiting significant modulation of melanocortin receptors 1 and 4. Its biological activities include inducing hair hypopigmentation, enhancing wound healing, and exhibiting antioxidant and anti-inflammatory properties. This compound is valuable for research applications focused on eumelanogenesis, hair follicle cycling, and the investigation of conditions such as benign gastric ulcers and rheumatoid arthritis. -
Building Block
L-Pyrohomoglutamic acid is an amino acid building block that serves as a precursor in the synthesis of ligands for FK506-binding proteins (FKBPs) and histone deacetylase (HDAC) inhibitors. This compound demonstrates key biological activity relevant to the modulation of protein functions and epigenetic regulation. Its versatile applications make it a valuable tool in chemical biology and medicinal chemistry research. -
Hapten
1-Adamantaneethanol is a hapten that modifies peptide binding to Major Histocompatibility Complex Class II (MHC II) molecules. This compound is utilized in immunological research to study T cell activation and the role of haptens in immune response modulation. Its ability to alter peptide presentation makes it a valuable tool for investigating MHC-related pathways and autoimmune conditions. -
Nrf2/AMPK/mTOR Activator
Hydroxycitric acid (tripotassium) is a potent activator of the Nrf2, AMPK, and mTOR signaling pathways. It enhances the expression of antioxidant enzymes, elevates glutathione levels, and inhibits ferroptosis, thereby providing protection against oxidative stress and promoting cellular health. This compound is actively engaged in regulating renal and pulmonary vascular functions and is also implicated in the induction of apoptosis in cancer cells through cell cycle arrest and DNA fragmentation. Its multi-target bioactivity makes it a valuable tool in research focused on oxidative stress, cancer biology, and metabolic regulation. -
Biochemical Assay Reagent
FAP Ligand 1 is a high-affinity small-molecule ligand that selectively targets fibroblast activation protein (FAP). This reagent is designed for conjugation with therapeutic agents, facilitating targeted delivery to FAP-expressing fibroblasts in cancer research. FAP Ligand 1 also has applications in radiation imaging studies, enhancing the visualization of tumors that express this biomarker. -
Anti-inflammatory Agent
Se-DMC is an anti-inflammatory agent that effectively attenuates the inflammatory response induced by complete Freund’s adjuvant (CFA) in murine models. It has demonstrated significant effects in reducing nociception and alleviating neurobehavioral deficits. This compound is valuable for research applications focused on understanding inflammation mechanisms and evaluating potential therapeutic interventions for inflammatory disorders. -
Anti-inflammatory
L-Leucinamide hydrochloride is an amino acid derivative that exhibits anti-inflammatory activity. It is utilized in research to investigate mechanisms of inflammation and may provide insights into therapeutic strategies for inflammatory diseases. Its role in modulating immune responses makes it a valuable tool for studying inflammatory pathways. -
Anti-inflammatory Agent
Chitoheptaose, a chitosan oligosaccharide, is recognized for its anti-inflammatory properties. It exhibits antioxidant, anti-inflammatory, and anti-apoptotic activities, making it a valuable tool in the investigation of myocarditis and related cardiovascular conditions. Research indicates that Chitoheptaose offers cardioprotective effects by improving critical cardiac parameters and modulating inflammatory cytokines such as IL-1β in various models. -
Anti-inflammatory Agent
Tesimide is an aryl/heteroarylidene pyridinedione that acts as an anti-inflammatory agent. It exhibits potent inhibition of pro-inflammatory cytokines and promotes the modulation of inflammatory pathways. Tesimide is valuable for research in inflammation-related conditions and may aid in the development of therapeutic interventions for various inflammatory diseases. -
Anti-inflammatory Agent
Zierin is a compound derived from Xeranthemum annuum L. that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory and antioxidant activities, making it a valuable tool for research into inflammatory diseases and oxidative stress. Its application in studies may enhance understanding of various biological pathways related to inflammation. -
Anti-inflammatory Agent
Anti-inflammatory agent 43 is a 6-methoxyflavonol glycoside that exhibits significant anti-inflammatory activity. This compound can be isolated from the aerial parts of Tetragonia tetragonoides. Its properties make it suitable for research applications focused on the modulation of inflammatory processes and the investigation of potential therapeutic options for inflammatory diseases.
