Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
Anti-inflammatory agent 44 is a 6-methoxyflavonol glycoside that exhibits significant anti-inflammatory activity. This compound, isolated from the aerial parts of Tetragonia tetragonoides, is instrumental in research focused on inflammation pathways and therapeutic interventions. Its properties make it a valuable reagent for studies aimed at understanding inflammatory responses and developing new anti-inflammatory treatments. -
Anti-Inflammatory Agent
Proxazole is an anti-inflammatory agent that exhibits protective effects against Indomethacin-induced ulcers without inducing anti-secretory activity. Additionally, Proxazole functions as a spasmolytic agent, displaying properties similar to those of papaverine. It is primarily utilized in research exploring gastrointestinal protection and inflammation modulation. -
Anti-Inflammatory Peptide
Transforming Growth Factor alpha (1-50) (rat) is an anti-inflammatory peptide that plays a crucial role in modulating immune responses. This peptide exhibits significant biological activity in reducing inflammation, making it a valuable tool for research in inflammation and immunology. Researchers can utilize TGF α (1-50) to investigate its mechanisms and potential therapeutic effects in various inflammatory conditions. -
iNOS Inhibitor
Glycylglycine hydrochloride hydrate is an iNOS inhibitor that acts as a non-selective dipeptidase substrate. This compound is capable of passive diffusion across cell membranes, where it is hydrolyzed to glycine, playing a role in energy metabolism and antioxidant activities. Glycylglycine hydrochloride hydrate promotes the proliferation of spermatogonial stem cells and mitigates astrocyte overactivation while decreasing nitric oxide release. Additionally, it upregulates the expression of neurotrophic factors, aiding in nerve myelin repair. This reagent is suitable for research into male reproductive biology and the neuroprotective mechanisms in neurodegenerative diseases. -
Anti-tumor Drug
L-Proline 4-methoxy-β-naphthylamide hydrochloride primarily targets FAP (Fibroblast Activation Protein) and serves as a potential anti-tumor agent. This compound is utilized in the preparation of FAP-activated anti-tumor compounds, making it relevant in cancer research and therapeutic development. Its unique chemical structure contributes to the exploration of novel strategies for targeting tumor microenvironments. -
Drug Impurity
Tacrolimus impurity 4 is a chemical impurity derived from the immunosuppressive drug Tacrolimus, primarily targeting FKBP12, a key protein involved in T-cell activation. This impurity serves as an important reference standard in quality control and analytical studies focused on the purification and characterization of Tacrolimus formulations. Its analysis aids in ensuring the safety and efficacy of Tacrolimus preparations in pharmaceutical research and development. -
Anti-inflammatory Agent
α-Truxillic acid, a dimer of α-trans-cinnamic acid, functions as an anti-inflammatory agent. While it does not possess analgesic properties, derivatives of α-truxillic acid linked to camphor fragments demonstrate significant activity in peripheral analgesic models, such as the writhing test. This compound is of interest for research applications focused on inflammation and pain pathways. -
Anti-Inflammatory Agent
Alisporivir intermediate-1 is a crucial intermediate in the synthesis of Alisporivir, which functions as an anti-inflammatory agent. This compound exhibits significant activity in modulating inflammatory pathways and is utilized in research focused on inflammatory and viral diseases. Its role in the synthetic pathway makes it valuable for further studies and applications in drug development. -
Anti-inflammatory compound
Triclacetamol is a trichloroacetyl derivative of acetaminophen that functions primarily as an anti-inflammatory compound. It exhibits weak inhibition of cyclooxygenase enzymes and demonstrates analgesic and antipyretic properties consistent with nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to its anti-inflammatory activity, Triclacetamol enhances the excretion of uric acid, making it a valuable reagent for research into inflammatory conditions and pain management. -
Anti-inflammatory Agent
Morniflumate is an orally active nonsteroidal anti-inflammatory agent that targets cyclooxygenase pathways to reduce inflammation. It demonstrates significant anti-inflammatory activity and is applicable in the study of inflammatory diseases, including osteoarthritis, painful musculoskeletal disorders, and soft tissue inflammation. Researchers may utilize Morniflumate to explore its therapeutic potential in various inflammatory conditions. -
Anti-inflammatory Agent
Gemin D is a polyphenolic compound derived from eucalyptus leaves that acts as an anti-inflammatory agent. It demonstrates notable cellular antioxidant activity, with an EC50 value of 15.57 μM. Gemin D is suitable for research applications focused on the mechanisms underlying inflammatory conditions and the exploration of potential therapeutic interventions. -
Antiinflammatory Agent
Sodium gualenate hydrate, a sodium salt derivative of guaiazulene, primarily acts as an anti-inflammatory agent. It exhibits significant biological activity in promoting wound healing and is commonly utilized in research related to gastrointestinal conditions such as duodenal ulcers, gastric ulcers, and gastritis. Its potential therapeutic applications in reducing inflammation make it a valuable reagent for studies in inflammatory disease pathways. -
Anti-Inflammatory Agent
Mofebutazone sodium is a monophenyl analogue of Phenylbutazone that functions as an orally active anti-inflammatory agent. This compound exhibits significant anti-inflammatory properties and is primarily utilized in asthma research to investigate its effects on respiratory conditions. Its mechanism of action involves the inhibition of cyclooxygenase enzymes, leading to decreased production of pro-inflammatory mediators. -
Anti-inflammatory Agent
NIP 502 is a pyridazinone derivative that acts as an anti-inflammatory agent targeting immune response pathways. This compound exhibits significant anti-inflammatory and immunomodulatory properties, making it valuable for investigating conditions such as asthma. Its efficacy in modulating inflammation positions NIP 502 as a critical reagent for research focused on respiratory disorders and related therapeutic developments. -
Anti-inflammatory Agent
Ibuproxam is a non-steroidal anti-inflammatory agent that exhibits potent inhibition of cyclooxygenase enzymes, thus reducing the synthesis of prostaglandins. This compound is utilized in various studies focused on pain relief and inflammation reduction, making it relevant for pharmacological research and therapeutic applications. Its mechanisms may contribute to further understanding of inflammatory pathways and potential drug development. -
Anti-inflammatory Agent
Isoxepac is an orally active non-steroidal anti-inflammatory agent that primarily targets inflammation pathways. It effectively inhibits carrageenan-induced paw edema and adjuvant-induced polyarthritis, alongside reducing prostaglandin synthesis. Isoxepac has demonstrated analgesic effects in postoperative pain management with minimal side effects. This compound is valuable for research involving inflammatory conditions, such as rheumatoid arthritis, and pain management studies. -
Anti-inflammatory Agent
Anti-inflammatory agent 106 is a derivative of Paeonol that functions as a potent anti-inflammatory agent. It demonstrates significant efficacy in inhibiting xylene-induced ear swelling in murine models, making it valuable for the study of inflammatory responses. This compound can be utilized in research focused on inflammatory diseases such as rheumatoid arthritis, psoriasis, and type 1 diabetes. -
Anti-inflammatory Agent
Betamethasone-17-butyrate-21-propionate is a potent anti-inflammatory agent primarily used in the treatment of inflammatory skin conditions. This synthetic corticosteroid acts by inhibiting the release of inflammatory mediators, thereby reducing erythema, swelling, and discomfort. Its efficacy makes it a valuable research tool for studying corticosteroid effects on skin inflammation and for evaluating therapeutic strategies in dermatological applications. -
Anti-inflammatory Agent
Bucloxic acid calcium is an anti-inflammatory agent classified as a pyrrazole derivative. It exhibits potent anti-inflammatory properties, making it suitable for research applications in chronic glomerular nephropathies. This compound can aid in the study of inflammatory processes and potential therapeutic interventions in kidney diseases. -
Anti-Inflammatory Agent
SM-8849 is a thiazole derivative characterized by its anti-inflammatory properties. This compound selectively targets and inactivates T cells associated with delayed-type hypersensitivity (DTH) reactions, effectively disrupting the key immunopathological processes implicated in arthritis while sparing humoral immune functions such as antibody synthesis. In a Type II Collagen-induced mouse model of arthritis, SM-8849 demonstrated significant efficacy by relieving clinical symptoms and mitigating bone destruction and joint damage. SM-8849 serves as a valuable reagent for research on autoimmune diseases, particularly rheumatoid arthritis. -
Anti-inflammatory Agent
HMR-4011A is a chemically modified derivative of Contignasterol, functioning as an orally active anti-inflammatory agent. It exhibits significant efficacy in reducing inflammation and has potential applications in respiratory research, particularly in the context of asthma. HMR-4011A offers valuable insights for studies focused on inflammatory pathways and therapeutic interventions. -
Anti-Inflammatory Agent
Mofebutazone is a monophenyl analogue of Phenylbutazone, functioning primarily as an anti-inflammatory agent. It exhibits potent anti-inflammatory activity and is utilized in research related to asthma and other inflammatory conditions. Its oral bioavailability makes it a valuable tool for studying the therapeutic effects of anti-inflammatory compounds in various biological models. -
Anti-inflammatory Agent
Stemospironine is an alkaloid derived from plants of the genus Hyacinth, functioning primarily as an anti-inflammatory agent. It exhibits significant biological activity as a cough suppressant while also serving as a valuable tool for investigating various inflammatory conditions. Its potential applications in research include exploring mechanisms of inflammation and evaluating therapeutic strategies for related diseases. -
Tumor Uptake Tracer
NOTA-FAPI-52 is a tumor uptake tracer that targets fibroblast activation protein (FAP). This compound can be radiolabeled for use in positron emission tomography (PET) imaging and other bioimaging methods. NOTA-FAPI-52 is particularly useful in studying diseases characterized by the overexpression of FAP, aiding in the understanding of various tumor environments and potential therapeutic interventions. -
Stable Isotope
1,10-Decanediol-d20 is the deuterated version of 1,10-decanediol, a diol compound known for its role in the formation of polymeric microparticles (paKG MPs) upon reaction with α-ketoglutarate (aKG). These microparticles facilitate the sustained release of aKG, promoting immunosuppressive responses by modulating dendritic cell metabolism, including reduced glycolysis and mitochondrial respiration. This modulation impacts the expression of key surface markers such as MHC-II and CD86 and influences the frequency of regulatory T cells and T-helper subsets in vitro. 1,10-Decanediol-d20 serves as a critical tool in immunometabolism research and is also useful as a surfactant or stabilizer in nanomaterial synthesis. -
Anti-Inflammatory Agent
1-beta-D-Arabinofuranosyluracil is an anti-inflammatory agent derived from the Caribbean sponge Tectitethya crypta. This compound exhibits a range of biological activities, including anti-inflammatory effects, analgesic properties, and vasodilation. Additionally, it has been shown to inhibit the proliferation of mouse lymphoma cells, making it a valuable reagent for research in cellular biology and inflammation studies. -
Stable Isotope
Pristane-d40 is a deuterium-labeled derivative of Pristane, which is a naturally occurring hydrocarbon found in various plants and marine organisms. This stable isotope is utilized in biological research to trace metabolic pathways and investigate lipid dynamics. Pristane has been shown to induce MHC class II-restricted, arthritogenic T cells in rat models, making this compound valuable for studies related to autoimmunity and immunological response. -
Anti-inflammatory Agent
Lonchocarpic acid acts as an anti-inflammatory agent, targeting pathways involved in neuroinflammation. It has demonstrated efficacy in models of LPS- or poly(I:C)-induced neuroinflammation, suggesting potential applications in investigating neuroinflammatory conditions. This compound is useful for researchers exploring the molecular mechanisms of inflammation and developing therapeutic strategies for related disorders. -
Isomer
(R,S,R)-ML334 is the isomer of ML334, serving as a valuable experimental control in research. This compound acts primarily as a cell-permeable activator of NRF2 by inhibiting the Keap1-NRF2 protein-protein interaction. With a binding affinity of 1 µM to the Kelch domain of Keap1, (R,S,R)-ML334 enhances NRF2 expression, promotes its nuclear translocation, and induces antioxidant response elements (ARE) activity, making it significant for studies related to oxidative stress and cellular defense mechanisms. -
CRBN Inhibitor
EM12-SO2F is a potent covalent inhibitor of the E3 ubiquitin ligase cereblon (CRBN), specifically binding to the histidine residue at position 353. This compound serves as a valuable chemical probe for studying CRBN-mediated pathways. EM12-SO2F effectively inhibits the lenalidomide-induced degradation of IKZF1 in MOLT4 cells, making it a useful tool for research in cancer biology and drug resistance. -
Fluorogenic Substrate
Ac-Gly-Pro-AFC is a fluorogenic substrate specifically designed to assess fibroblast activation protein (FAP) endopeptidase activity. This compound exhibits high sensitivity and selectivity, making it useful for studying FAP's role in tumor microenvironments and fibrosis. It is applicable in various research domains, including cancer biology and tissue remodeling studies, facilitating the quantification of enzymatic activity in biological samples. -
Anti-inflammatory Agent
Epmedin C is an orally active anti-inflammatory agent and immunomodulator that targets multiple key proteins, including UCP1, Caspase-1, CDK2, and Keap1. This compound effectively inhibits epithelial cell proliferation by disrupting the CDK2/Cyclin E complex, while also upregulating Nrf2 expression, reducing reactive oxygen species levels, and inhibiting the secretion of pro-inflammatory cytokines. Through these mechanisms, Epmedin C aids in restoring antibody production and alleviating tissue damage, making it relevant for research on conditions such as obesity, immunotoxicity induced by Deoxynivalenol, and mammary hyperplasia. -
Anti-inflammatory Agent
Saikosaponin A is an anti-inflammatory agent primarily derived from Bupleurum chinense. It effectively regulates lipid metabolism and promotes cholesterol efflux, making it relevant in early atherosclerosis research. Furthermore, Saikosaponin A acts as a potential agonist of peroxisome proliferator-activated receptor γ (PPAR-γ), significantly enhancing its expression. This compound is particularly useful in studies related to hyperlipidemic pancreatitis. -
CXCR Agonist
VUF11207 is a potent agonist of the CXCR7 receptor, demonstrating a high affinity with a pKi of 8.1. This compound effectively induces the recruitment of β-arrestin2, with an pEC50 value of 8.8, and promotes the subsequent internalization of CXCR7, with an pEC50 of 7.9. VUF11207 is valuable for research applications focused on CXCR signaling pathways and β-arrestin-mediated processes. -
COX-1 Inhibitor
FR122047 (hydrochloride) is a selective inhibitor of cyclooxygenase-1 (COX-1) with an IC50 value of 28 nM. This compound exhibits antiplatelet, analgesic, and anti-inflammatory activities, making it a valuable tool for research in the fields of pain management and cardiovascular studies. Its ability to modulate COX-1 offers insights into the therapeutic targeting of inflammatory pathways. -
Anti-inflammatory Agent
Physalin L is an anti-inflammatory agent that inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophages, achieving an average inhibitory rate of 70.97%. This compound is valuable for research focused on inflammation pathways and can be utilized to investigate its potential therapeutic effects in various inflammatory conditions. -
Cyclophilin D Activator
Talatisamine is an orally active cyclophilin D activator derived from the roots of Aconitum carmichaeli Debx. It functions primarily by preventing calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) with an IC50 of 78 μM and inhibiting delayed rectifier K+ channels with an IC50 of 146 μM. Talatisamine demonstrates significant antioxidant and membrane-stabilizing properties, effectively inhibiting lipid peroxidation and preserving mitochondrial membrane integrity. Its diverse biological activities include antiarrhythmic, hypotensive, anti-inflammatory, anticancer, and neuroprotective effects, making it a valuable tool in the study of ischemic diseases, rheumatoid arthritis, inflammation-related conditions, and Alzheimer's disease. -
Anti-inflammatory Agent
Chikusetsusaponin IVa is an orally active anti-inflammatory agent that targets YAP, demonstrating a binding affinity with a KD value of 0.388 mM. This compound effectively reduces the expression of inflammatory mediators such as IL-6, IL-10, and COX-2, while modulating nitric oxide production and promoting reactive oxygen species generation. Additionally, Chikusetsusaponin IVa induces apoptosis, inhibits MAPK and TAZ signaling pathways, and regulates Nrf2 and JAK/STAT pathways. It exhibits potential as an anti-H9N2 avian influenza virus agent and demonstrates anti-cancer properties, along with hepatoprotective and osteoprotective effects, making it a valuable tool for research in inflammation and cancer biology. -
Anti-inflammatory Agent
Praeruptorin A is an anti-inflammatory compound derived from Peucedanum praeruptorum. It demonstrates significant anti-inflammatory activity by inhibiting NF-κB activation, which is crucial for mediating inflammatory responses. This compound is valuable in research applications focused on inflammation-related signaling pathways and the development of anti-inflammatory therapies. -
nNOS Inhibitor
2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a Ki value of 20 μM. It effectively antagonizes BH4-induced nNOS dimerization, thereby modulating nitric oxide synthesis in neuronal tissues. In addition to its role as an nNOS inhibitor, 2-Thiouracil also has antithyroid properties and serves as a specific marker for melanoma detection. Furthermore, it promotes root growth in pea and corn, making it a valuable tool for various agricultural and biochemical research applications. -
COX Inhibitor
Zaltoprofen is a non-steroidal anti-inflammatory drug (NSAID) that acts as a preferential inhibitor of cyclooxygenase-2 (COX-2), exhibiting IC50 values of 1.3 μM for COX-1 and 0.34 μM for COX-2. It demonstrates significant anti-inflammatory and analgesic properties, making it beneficial for the management of inflammatory pain. Zaltoprofen is utilized in research settings to explore mechanisms of inflammation and pain pathways. -
COX-1/COX-2 Inhibitor
6-Methoxy-2-naphthoic acid is a potent inhibitor of COX-1 and COX-2 enzymes. It effectively inhibits the synthesis of gastric mucosal prostaglandin E2, making it relevant in studies related to inflammation and pain-related conditions. Additionally, 6-Methoxy-2-naphthoic acid serves as an impurity in Naproxen and can be utilized in the synthesis of various active compounds, contributing to diverse research applications in pharmaceutical development. -
Antiinflammatory Agent
Sodium gualenate is a hydrophilic derivative of guaiazulene that functions as an anti-inflammatory agent. It exhibits significant anti-inflammatory and wound-healing properties, making it useful in the treatment of conditions such as duodenal ulcers, gastric ulcers, and gastritis. This compound is valuable for research focused on gastrointestinal health and the modulation of inflammatory responses. -
COX-2 Inhibitor
Parecoxib Sodium is a selective COX-2 inhibitor that effectively penetrates the blood-brain barrier and serves as a proagent for Valdecoxib. This nonsteroidal anti-inflammatory drug (NSAID) inhibits prostaglandin synthesis, making it suitable for the relief of acute postoperative pain as well as for managing symptoms associated with chronic inflammatory conditions, including osteoarthritis and rheumatoid arthritis. It has important applications in both clinical and preclinical research focused on pain management and inflammation. -
COX Inhibitor
Tolmetin sodium dihydrate is a potent non-steroidal anti-inflammatory drug (NSAID) that primarily targets cyclooxygenase (COX) enzymes, exhibiting IC50 values of 0.35 μM for human COX-1 and 0.82 μM for COX-2. This compound is commonly utilized in research related to inflammation and pain modulation. Its ability to effectively inhibit COX activity makes it valuable for studying various inflammatory pathways and developing new therapeutic strategies in pain management. -
iNOS Inhibitor
Glycylglycine, an iNOS inhibitor, is a dipeptide that serves as a non-selective glycylglycine dipeptidase substrate. It effectively crosses cell membranes through passive diffusion and is subsequently hydrolyzed to glycine, which participates in energy metabolism and antioxidant defense. This compound promotes the proliferation of spermatogonial stem cells (SSCs), mitigates astrocyte overactivation, and reduces nitric oxide (NO) release while enhancing the expression of neurotrophic factors such as PDGFA, FGF2, and CNTF, thereby supporting nerve myelin repair. Glycylglycine is valuable in research on male reproductive biology and neurodegenerative diseases, including the investigation of neuroprotective mechanisms in conditions like multiple sclerosis. -
NO Synthase Activator
Bendazol is a nitric oxide synthase activator that plays a significant role in vascular smooth muscle relaxation. Its primary biological activity involves the dilation of blood vessels, leading to reduced peripheral resistance and improved blood circulation, making it useful in the study of antihypertensive effects. Bendazol has been shown to inhibit myopia development in rabbit models and positively influences kidney function by enhancing NO synthase activity in nephrogenic hypertension models. Additionally, this compound affects sexual behavior and spermatogenesis in male rats, contributing to its relevance in reproductive health research. -
Anti-inflammatory Compound
Methyl 2-acetoxybenzoate, also known as methyl acetylsalicylate, serves as a prodrug that exerts anti-inflammatory effects. Upon chemical or enzymatic hydrolysis, it converts to methyl 2-hydroxybenzoate, which is known for its analgesic properties. This compound is applicable in research pertaining to inflammatory diseases and can be utilized as an analgesic agent in topical formulations such as liniments. -
Anti-inflammatory Agent
6α-Fluoroprednisolone is an anti-inflammatory agent that serves as an internal standard for the analysis of methylprednisolone, prednisolone, and prednisone. This compound is essential for research applications related to congenital adrenal virilism and Addison's disease, aiding in the understanding of adrenal function and corticosteroid therapy. It is an invaluable tool for studies focused on steroid hormone action and metabolic regulation. -
COX Inhibitor
Hamaudol is a chromone derived from Saposhnikovia divaricata, acting as a potent inhibitor of cyclooxygenase (COX)-1 and COX-2, with IC50 values of 0.30 mM and 0.57 mM, respectively. This compound exhibits significant analgesic and anti-inflammatory properties, making it a valuable tool in research focused on pain relief and inflammation modulation. Hamaudol is suitable for investigations into COX inhibition and related biological pathways.
