Catalog No.
Product Name
Application
Product Information
Citations
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Anti-Inflammatory Corticosteroid
Paramethasone is an anti-inflammatory corticosteroid that targets glucocorticoid receptors. It is known for its ability to reduce inflammation and modulate immune responses, making it valuable in the treatment of various inflammatory and autoimmune conditions. This compound is commonly utilized in research to investigate corticosteroid mechanisms and therapeutic applications in disorders such as asthma, arthritis, and other inflammatory diseases. -
Anti-inflammatory and Protein-Binding Inhibitor
4-Acetylaminoantipyrine is a derivative of antipyrine that functions primarily as an anti-inflammatory agent and a protein-binding inhibitor. It acts as a PGE2-dependent blocker and inhibits cyclooxygenase (COX), thereby modulating inflammatory pathways. Additionally, 4-acetylaminoantipyrine has the capability to inhibit Cu/Zn superoxide dismutase (Cu/ZnSOD) and can spontaneously bind with bovine serum albumin (BSA), resulting in conformational changes. This compound is valuable for research applications in inflammation and protein interaction studies. -
CCR5/CXCR4 Chemotaxis Inhibitor
Catenarin, an anthraquinone compound, serves as an inhibitor of CCR5 and CXCR4-mediated chemotaxis. It effectively reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), as well as calcium mobilization. Catenarin demonstrates anti-inflammatory properties and inhibits leukocyte migration, contributing to its potential in diabetes research. Additionally, it exhibits significant antibacterial activity against Gram-positive bacteria and has been shown to prevent type 1 diabetes in nonobese diabetic mice. -
Pro-inflammatory Mediator Inhibitor
Heparin disaccharide III-S (trisodium) is a heparin-derived disaccharide that serves as a pro-inflammatory mediator inhibitor. It effectively inhibits the spontaneous secretion of interleukin-8 (IL-8) and interleukin-1 beta (IL-1β) in intestinal epithelial cells by acting at the post-translational level without affecting mRNA or intracellular mediator concentrations. This compound is useful for research on inflammatory responses and the regulation of cytokine secretion in intestinal models. -
Pro-inflammatory Mediator Inhibitor
Heparin disaccharide I-H (trisodium) is a heparin-derived disaccharide that acts as a pro-inflammatory mediator inhibitor. This compound effectively blocks the spontaneous secretion of IL-8 and IL-1β in intestinal epithelial cells at the post-translational level, while leaving mRNA expression levels and intracellular contents unaffected. Demonstrating dose-dependent anti-inflammatory activity, Heparin disaccharide I-H (trisodium) is valuable for research applications targeting intestinal inflammation and associated signaling pathways. -
Insecticide
Furathiocarb is a carbamate pro-insecticide that primarily targets insect nervous systems. It exhibits significant biological activity by inducing the proliferation of MHC II-positive B cells in auricular lymph nodes and promoting the production of Th1 cytokines, including IL-2, TNF-γ, and IFN-γ. Furathiocarb has applications in contact allergy research, demonstrating no respiratory allergy induction in mice. After dermal absorption in isolated rats, it is fully metabolized to carbofuran, with skin permeation rates for emulsifiable concentrate and wettable powder formulations exceeding those of the parent compound. -
Anti-inflammatory/Analgesic Agent
Nitraquazone is an anti-inflammatory and analgesic agent that inhibits phosphodiesterase, leading to increased intracellular levels of cyclic adenosine monophosphate (cAMP). This mechanism underlies its potential use in research focused on inflammation and pain management. Nitraquazone serves as a valuable tool in the investigation of anti-inflammatory pathways and analgesic effects in various biological contexts. -
Cyclophilin Inhibitor
RN-0001 is a potent inhibitor of cyclophilins, specifically demonstrating Ki values of 4.1 nM and 12.0 nM against Cyclophilin A (CypA) and Cyclophilin D (CypD), respectively. By directly binding to CypD, RN-0001 effectively inhibits its peptidyl-prolyl cis-trans isomerase activity, preventing mitochondrial permeability transition pore opening. This compound enhances mitochondrial function, diminishes reactive oxygen species (ROS) production, and downregulates lipogenic marker expression. Additionally, RN-0001 inhibits NF-κB p65 nuclear translocation and reduces the release of activated caspase-3 and cytochrome c, making it a valuable tool for investigating alcohol-associated liver disease. -
CXCR4 Positive Allosteric Modulator
UCUF-965 is a positive allosteric modulator of the chemokine receptor CXCR4. This compound enhances CXCL12-induced β-arrestin recruitment and cAMP signaling, promoting lymphoblast migration and inducing calcium flux without binding to the orthosteric CXCL12 site. UCUF-965 also modulates microRNA levels in fibroblasts by reducing miR-15b and miR-29a, while increasing miR-146a. Its capabilities in enhancing angiogenesis and accelerating wound healing make UCUF-965 a valuable tool in research focused on diabetic wound healing impairment. -
CXCR5 Inhibitor
YU241279 is a selective inhibitor of CXCR5, targeting the CXCL13-mediated signaling pathways. It effectively inhibits Gαq-dependent calcium influx and Gαi2-dependent cAMP reduction in CXCR5-expressing cells, leading to reduced proliferation of lymphoma cells. In preclinical studies, YU241279 demonstrated a significant reduction in tumor burden within the peripheral blood and bone marrow of mice with lymphoma. This compound is suitable for research into angioimmunoblastic T-cell lymphoma and Burkitt B-cell lymphoma. -
Anti-inflammatory/tumor Agent
Hesperetin triacetate is a compound known for its anti-inflammatory and anti-tumor properties. It exerts its effects by inhibiting the denaturation of bovine serum albumin in vitro and reducing carrageenan-induced paw swelling in mouse models in vivo. Additionally, Hesperetin triacetate demonstrates anti-proliferative activity against breast cancer cells, inducing DNA degradation and apoptosis. This compound is suitable for research focused on breast cancer and inflammation mechanisms. -
Immunological Adjuvant
Pristane is a naturally occurring hydrocarbon oil that functions as an immunological adjuvant. It is used to induce MHC class II-restricted, arthritogenic T cells in experimental models, particularly in rat studies. Pristane's unique properties make it valuable for research applications focused on immune response modulation and the study of autoimmune conditions. -
Non-steroidal Anti-inflammatory Agent
Lotifazole is a non-steroidal anti-inflammatory agent that specifically inhibits delayed-type hypersensitivity without relying on the prostaglandin synthesis inhibition pathway at low doses. It demonstrates significant efficacy in reducing paw edema induced by carrageenan in rats, alleviating erythema caused by ultraviolet radiation in guinea pigs, and mitigating pleurisy at high doses. Lotifazole is valuable for research into T-cell-mediated diseases, providing insights into potential therapeutic strategies. -
Anti-Inflammatory Agent
Genipin 1-β-D-gentiobioside is an iridoid glycoside extracted from Gardenia jasminoides, exhibiting strong anti-inflammatory properties. This compound demonstrates hepatoprotective and antioxidant activities, making it valuable for research on liver health and inflammation-related pathways. Its antithrombotic effects also highlight its potential in cardiovascular studies. -
Anti-inflammatory Agent
Delmetacin is an anti-inflammatory agent that primarily targets cyclooxygenase enzymes, thereby inhibiting prostaglandin synthesis. This mechanism results in the reduction of inflammation and pain. Delmetacin is utilized in various research applications focused on inflammatory diseases and pain management, making it a valuable tool for understanding inflammatory pathways and developing new therapeutic strategies. -
Anti-Inflammatory Agent
Butin is a biologically active flavonoid primarily targeting anti-inflammatory pathways. Isolated from the heartwood of Dalbergia odorifera, Butin exhibits strong antioxidant and antiplatelet properties. It has been shown to significantly alleviate myocardial infarction symptoms, enhance cardiac function, and prevent diabetes-induced oxidative damage in the heart in rat models, making it a valuable compound for cardiovascular and metabolic research applications. -
Anti-Inflammatory Agent
11-O-Galloylbergenin is an anti-inflammatory agent derived from the ethanolic extract of Mallotus philippinensis. This compound exhibits significant analgesic and anti-inflammatory properties, making it a valuable tool for research related to pain management and inflammatory conditions. Its potential utility in therapeutic applications underscores its importance in pharmacological studies. -
Antiinflammatory Agent
Fenclozine dimaleate is a non-steroidal anti-inflammatory agent that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory activity and is utilized in research to investigate various inflammatory conditions and their underlying mechanisms. Its potential applications include studying pain relief and reducing inflammation in both in vitro and in vivo models. -
Anti-Neuroinflammatory Agent
Fendleryl B is an anti-neuroinflammatory agent derived from the edible mushroom Gambas. This compound demonstrates significant potential in modulating neuroinflammatory responses, making it valuable for studying neurological diseases and related pathologies. Its ability to influence neuroinflammation positions it as a promising candidate for research in neurodegenerative disorders. -
Secondary Metabolite
Cymbimicin B is a secondary metabolite that specifically targets cyclophilin A, a member of the cyclophilin family of proteins. This compound exhibits impressive inhibitory activity, making it valuable for research into the role of cyclophilins in various biological processes, including immunosuppression and protein folding. Its unique mechanism of action positions Cymbimicin B as a useful tool in studies related to cellular stress responses and therapeutic applications in autoimmune diseases. -
anti-inflammatory agent
Lofemizole is a non-steroidal anti-inflammatory agent that inhibits the activity of cyclooxygenase enzymes, leading to a reduction in prostaglandin synthesis. This compound exhibits significant anti-inflammatory properties, making it valuable in the study of inflammatory diseases. Lofemizole can be utilized in research to explore therapeutic strategies for conditions characterized by chronic inflammation. -
Anticancer Agents
Hericenone A is an isoindoline compound derived from the fruiting bodies of Hericium erinaceum. Exhibiting potent anticancer activity, it effectively inhibits the growth of SMMC-7221 and MHCC-97H cell lines at a concentration of 20 μg/mL. This compound is of particular interest in cancer research for its potential therapeutic applications. -
Ecto-5'-Nucleotidase Inhibitor
2,4-Dinitrobenzenesulfonic acid is an ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 63 μM for human enzymes and 144 μM for rat enzymes. This compound effectively inhibits the hydrolysis of adenosine monophosphate (AMP), preventing the production of adenosine. It is primarily utilized in cancer research to study the role of ecto-5'-nucleotidase in tumor biology and therapeutic resistance. -
COX Inhibitor
Methylhydroquinone is a potent COX inhibitor with noted activity against ovine COX-1 and human recombinant COX-2, exhibiting IC50 values of 480.7 μM and 52.2 μM, respectively. This compound demonstrates anti-inflammatory properties primarily through the inhibition of prostaglandin synthesis. Additionally, it has been associated with potential DNA-damaging effects, including the induction of DNA single-strand breaks. Methylhydroquinone functions by competitively binding to the active sites of COX-1, engaging in non-covalent interactions to exert its biological activities. -
Anti-inflammatory Compound
Triptoquinone H is an anti-inflammatory compound derived from the traditional Chinese medicine Tripterygium hypoglaucu. It exhibits significant cytotoxic, immunomodulatory, and anti-inflammatory activities, making it a valuable tool for studying cancer and inflammatory diseases. Researchers can utilize Triptoquinone H to explore its therapeutic potential and mechanisms in various biological contexts. -
Nonsteroidal Anti-inflammatory Drug
Clofenamic acid, a nonsteroidal anti-inflammatory drug, primarily targets cyclooxygenase enzymes (COX-1 and COX-2) to inhibit prostaglandin synthesis. It exhibits significant anti-inflammatory and analgesic properties, making it a useful tool for studying inflammatory processes. Clofenamic acid is particularly relevant in research related to rheumatoid arthritis and other inflammatory disorders. -
Secondary Metabolite
Cymbimicin A is a secondary metabolite that binds specifically to cyclophilin A. This interaction modulates various cellular processes, making it a valuable tool in studies related to immunology and cancer research. Its unique mechanism may provide insights into cyclophilin-mediated signaling pathways and potential therapeutic targets. -
Anti-Inflammatory Agent
Broperamole is an anti-inflammatory agent that acts primarily by modulating inflammatory pathways. It exhibits both systemic and topical anti-inflammatory activity, making it a valuable tool for the investigation of inflammation-related disorders. This compound can be utilized in research applications focused on pain management and therapeutic interventions for inflammatory conditions. -
AntiInflammatory Agent
Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) functions as a potent anti-inflammatory agent by reducing the expression of inducible nitric oxide synthase (iNOS). It effectively inhibits the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β. Additionally, Coixol has been shown to enhance glucose tolerance and lower plasma insulin levels, contributing to a reduction in blood glucose levels. This compound is valuable for research applications focused on inflammation and metabolic disorders. -
Anti-inflammatory Agent
Phenylbutazone trimethylgallate serves as a non-steroidal anti-inflammatory agent with oral bioavailability. It exhibits significant anti-inflammatory properties, making it useful for the study of inflammatory pathways and conditions. This compound may be utilized in research to explore its mechanistic effects and potential therapeutic benefits in various inflammatory diseases. -
Anti-inflammatory Drug
Visnagin is an antioxidant furanocoumarin derivative that targets inflammatory pathways to exhibit significant anti-inflammatory and analgesic properties. It demonstrates strong potential in preventing cerulein-induced acute pancreatitis, making it relevant for studies of pancreatic inflammation. Additionally, visnagin displays notable vasodilator effects in vascular smooth muscle, suggesting its utility in cardiovascular research applications. -
Anti-inflammatory Agent
AIM-102 is an immune-modulating anti-inflammatory agent targeting pathways involved in inflammatory responses. It effectively inhibits LPS-induced neutrophilia, making it a valuable tool for research in inflammation and immunology, particularly in studies related to allergic asthma. AIM-102 facilitates a deeper understanding of immune mechanisms and the modulation of inflammatory processes in various disease contexts. -
Non-Steroidal Anti-Inflammatory Drug
Bumadizone calcium is the calcium salt form of Bumadizone, functioning as a non-steroidal anti-inflammatory drug (NSAID). It has demonstrated efficacy in alleviating symptoms associated with chronic inflammatory diseases. However, it is important to note that Bumadizone calcium can be irritating to the gastric lining, potentially resulting in gastric bleeding and ulceration. This compound is primarily utilized in research investigating anti-inflammatory pathways and associated gastrointestinal effects. -
Anti-inflammatory Agent
Anti-inflammatory Agent 82 is designed to inhibit inflammatory pathways, providing potential analgesic effects. Its mechanism of action may involve the modulation of pro-inflammatory cytokines, thus reducing inflammation in various tissues. This reagent is suitable for research applications focused on pain management and inflammatory disease models. -
Anti-inflammatory Agent
Fanetizole mesylate is an anti-inflammatory agent that targets pro-inflammatory pathways to mitigate inflammation. It demonstrates significant biological activity in reducing inflammation and can be utilized in research focused on various inflammatory diseases. This compound is instrumental for studies investigating therapeutic interventions in inflammatory conditions. -
Bifunctional molecule
EcDHFR/FKBP12 F36V binder-1 is a bifunctional molecule designed to target the Escherichia coli dihydrofolate reductase (EcDHFR) domain and the FKBP12 F36V domain. This compound exhibits significant biological activity by acting as an efficient linker between the two protein domains, facilitating studies of protein-protein interactions and enabling the development of synthetic biological systems. Its applications include protein engineering, understanding signaling pathways, and advancing drug discovery efforts. -
Anti-inflammatory Agent
Neuroprotective Agent 4 is a novel small molecule that functions primarily as an antioxidant and anti-inflammatory agent. It exhibits significant neuroprotective effects, making it a valuable tool in the study of ischemic stroke and associated neurodegenerative diseases. This compound is instrumental in exploring therapeutic strategies for conditions characterized by oxidative stress and inflammation in neural tissues. -
Antiinflammatory Agent
K 308 is a non-steroidal anti-inflammatory agent that inhibits the production of pro-inflammatory cytokines. It demonstrates significant biological activity in reducing inflammation and providing symptomatic relief in various inflammatory conditions. This compound is valuable for research applications focused on understanding inflammatory pathways and developing novel therapeutic strategies for chronic diseases. -
Anti-inflammatory Agent
Flavanone hydrazone is a potent non-steroidal anti-inflammatory agent that primarily targets inflammatory pathways. It effectively inhibits ocular inflammation induced by lens proteins, making it a valuable compound for research related to eye health and inflammatory responses. This compound can be utilized in studies exploring the mechanisms of inflammation and potential therapeutic applications in ocular diseases. -
Anti-inflammatory Agent
Butetamate (HH105) is an anti-inflammatory agent primarily targeting inflammatory pathways. This compound demonstrates potential efficacy in alleviating symptoms associated with respiratory system conditions. It can be utilized to formulate thin films for research applications focused on inflammation and respiratory health. -
Anti-inflammatory Agent
Flufenamate aluminum is a non-steroidal anti-inflammatory agent that inhibits cyclooxygenase (COX) enzymes, leading to a reduction in prostaglandin synthesis. It exhibits significant anti-inflammatory activity and is utilized in research related to pain management and inflammatory processes. This compound is valuable for studying various inflammatory diseases and potential therapeutic interventions. -
Anti-inflammatory Agent
Malkangunin, an anti-inflammatory agent derived from red ginseng, exhibits significant biological activity in modulating inflammatory processes. Its potential applications in medical research include addressing conditions such as premature ovarian failure, making it a valuable compound for studies focused on reproductive health and inflammation-related disorders. -
Anti-inflammatory Agent
Anti-inflammatory agent 34 (Compound IVf) is an orally bioavailable anti-inflammatory reagent that functions by inhibiting key inflammatory pathways. This compound exhibits significant analgesic properties and is useful in research focused on pain management and inflammation-related disorders. Its application extends to studies investigating the molecular mechanisms of inflammation and the development of therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
4-Hydroxy-2,3-dimethoxyxanthone is an anti-inflammatory agent derived from Hypericum oblongifolium. This compound exhibits significant inhibition of inflammatory pathways, making it valuable in research focused on chronic inflammation and related diseases. Its potential applications include studying mechanisms of inflammation and developing novel therapeutic strategies in inflammatory disorders. -
Anti-Inflammatory Agent
Polyporoid B is an ergostane-type ecdysteroid that serves as a potent anti-inflammatory agent. It demonstrates significant anti-inflammatory activity in vivo, making it a valuable tool for research in inflammation-related studies and therapeutic development. Its unique mechanism of action may provide insights into new treatments for inflammatory diseases. -
Nonsteroidal Antiinflammatory Agent
IDPH-8261 is an orally active nonsteroidal anti-inflammatory agent that targets cyclooxygenase enzymes to inhibit prostaglandin synthesis. Its key biological activity includes reducing inflammation and alleviating pain associated with various inflammatory conditions. This compound is applicable in research focused on inflammatory diseases, including arthritis, and may facilitate the investigation of therapeutic strategies for managing chronic inflammation. -
Anti-Inflammatory Agent
Riztunitide is an anti-inflammatory agent that targets specific pathways involved in the inflammatory response. It demonstrates significant efficacy in reducing inflammation and modulating immune system activity, making it a valuable tool for research in chronic inflammatory diseases. Its application in various preclinical models supports investigations into potential therapeutic strategies for conditions characterized by excessive inflammation. -
Nonsteroidal Anti-inflammatory Agent
Enfenamic acid is a nonsteroidal anti-inflammatory agent that functions as a prostaglandin synthetase inhibitor. It has demonstrated the ability to inhibit hepatic gluconeogenesis in Swiss albino mice, showcasing its role in metabolic regulation. Enfenamic acid is also known to suppress wound healing, making it relevant for research in inflammation and tissue repair mechanisms. -
Anti-inflammatory Agent
30-Hydroxyquinoa-saponin 1 is an anti-inflammatory agent derived from quinoa saponins. It demonstrates potential biological activity in modulating inflammatory processes and can be utilized in research focused on various inflammatory conditions. Its unique properties may aid in the understanding of inflammation-related mechanisms and the development of therapeutic strategies. -
Anti-inflammatory Agent
DF-1012 is an orally active anti-inflammatory agent that exhibits significant inhibitory effects on inflammatory pathways. This compound has shown potential in reducing cough reflex associated with inflammatory conditions. It is suitable for research applications focused on inflammation and respiratory disorders.
