Fig. 1 · Structure
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(±)-Nornicotine-d4
Stable Isotope
(±)-Nornicotine-d4 is a deuterium-labeled analog of (±)-Nornicotine, a significant metabolite of nicotine. It acts as a partial agonist at nicotinic acetylcholine receptors (nAChRs), particularly those containing α7 and α6 subunits, influencing various biological pathways. This compound has been shown to disrupt β-catenin and ZO-1 interactions while inducing F-actin depolymerization. (±)-Nornicotine-d4 is valuable for research focused on atherosclerosis, Alzheimer's disease, and schizophrenia, providing insights into nicotine's metabolic effects and related neurological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 66148-18-3 |
| Applications | Stable Isotope |
| Formula | C9H8D4N2 |
| Molecular Weight | 152.23 |
| Synonyms | Nornicotine-d4 |
| SMILES | [2H]C1=C(C2NCCC2)C([2H])=C([2H])C([2H])=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.