Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Ilaprazole-d3 is a deuterium-labeled derivative of Ilaprazole, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic profiling. It allows for the accurate quantification of Ilaprazole in biological samples, facilitating research applications in drug metabolism and pharmacodynamics. -
Stable Isotope
Belotecan-d7 hydrochloride is a deuterium-labeled derivative of Belotecan hydrochloride, a potent Topoisomerase I inhibitor. This stable isotope is utilized in pharmacokinetic studies and metabolic research, providing insights into the mechanism of action and therapeutic efficacy of camptothecin analogs. It is particularly valuable for tracing metabolic pathways and studying drug interactions in various biological systems. -
Stable Isotope
Mitoxantrone-d8 is a deuterium-labeled derivative of Mitoxantrone, a known inhibitor of topoisomerase II. This compound also shows inhibition of protein kinase C (PKC) with an IC50 value of 8.5 μM. Mitoxantrone-d8 is particularly useful in studies involving pharmacokinetics and drug metabolism, providing a stable isotope for quantitative analysis in research applications. -
Stable Isotope
RPR132595A-d3 is a deuterated form of RPR132595A, a prominent active metabolite of Irinotecan (CPT-11). This compound undergoes metabolism via cytochrome P-450 3A4 (CYP3A4) and is ultimately eliminated through the urine. RPR132595A-d3 serves as a valuable stable isotope for studies in drug metabolism and pharmacokinetics, enabling precise tracking and quantification of metabolic pathways involving Irinotecan. -
Stable Isotope
RPR121056-d3 is a deuterated analog of RPR121056, a metabolite of the anticancer drug Irinotecan. It primarily targets and inhibits topoisomerase type I, leading to apoptosis in cancer cells. RPR121056-d3 is utilized in research applications focused on understanding the metabolic pathways and pharmacokinetics of Irinotecan, particularly in the context of colorectal cancer therapy. Additionally, it may also provide insights into the inhibition of acetylcholinesterase (AChE). -
Stable Isotope
1-Hydroxypyrene-d9 is a deuterated form of 1-Hydroxypyrene, serving as a stable isotope used for analytical applications. It functions as a biomarker for exposure to polycyclic aromatic hydrocarbons (PAHs), particularly in urine samples. Additionally, 1-Hydroxypyrene serves as an agonist for the aryl hydrocarbon receptor (AhR), implicating its role in various biological pathways, including renal fibrosis. This compound is valuable for research focused on environmental health and toxicology. -
Stable Isotope
Atenolol-d7 is a deuterium-labeled variant of Atenolol, a cardioselective β1-adrenergic receptor blocker that exhibits a Ki value of 697 nM at the β1-adrenoceptor in guinea pig left ventricle membranes. This stable isotope is instrumental in pharmacokinetic studies and metabolic research related to hypertension and angina pectoris. Its unique properties facilitate the investigation of drug metabolism and disposition in biological systems. -
Stable Isotope
Calcium phosphorylcholine-d9 chloride is a deuterium-labeled derivative of calcium phosphorylcholine chloride, a key phospholipid component found in eukaryotic biofilms. This compound is prevalent in both commensal and pathogenic bacteria that associate with eukaryotic hosts in prokaryotic environments. Additionally, calcium phosphorylcholine chloride displays a diverse array of immunomodulatory properties, making it useful for research in immunology and microbiology. -
Stable Isotope
Metoprolol-d7 hydrochloride is a deuterated form of Metoprolol, a selective β1-adrenoceptor antagonist. This compound exhibits notable anti-inflammatory, antitumor, and anti-angiogenic properties, making it valuable for various biochemical studies. Metoprolol-d7 hydrochloride is instrumental in pharmacokinetic studies and tracer applications due to its stable isotope nature, enabling precise tracking and analysis in metabolic research. -
Stable Isotope
Propranolol-d7 is a stable isotope-labeled form of Propranolol, a nonselective β-adrenergic receptor (βAR) antagonist. It exhibits high affinity for β1AR and β2AR, with inhibition constants (Ki) of 1.8 nM and 0.8 nM, respectively. Propranolol's capability to inhibit [3H]-DHA binding to rat brain membranes, with an IC50 of 12 nM, makes it a valuable tool for researching conditions such as hypertension, myocardial infarction, cardiac arrhythmias, and other cardiovascular disorders. -
Stable Isotope
DL-Norepinephrine-d6 is a deuterium-labeled form of DL-Norepinephrine, a racemic catecholamine neurotransmitter. This compound comprises equal parts of the active L-stereoisomer and the inactive D-stereoisomer. DL-Norepinephrine-d6 serves as a valuable tracer in biochemical studies, including investigations into neurodegenerative diseases such as Parkinson's disease, enabling researchers to study neurotransmitter dynamics and metabolic pathways with enhanced precision. -
Stable Isotope
Propranolol-d7 (ring-d7) is a deuterated analogue of Propranolol hydrochloride, a nonselective β-adrenergic receptor antagonist. It exhibits high affinity for both β1 and β2 adrenergic receptors, with Ki values of 1.8 nM and 0.8 nM, respectively. This compound inhibits [3H]-DHA binding in rat brain membranes with an IC50 of 12 nM, making it a valuable tool for studying cardiovascular conditions such as hypertension, myocardial infarction, and cardiac arrhythmias. Propranolol-d7 (ring-d7) is particularly useful in pharmacokinetic and metabolic studies using mass spectrometry due to its stable isotope labeling. -
Stable Isotope
Medetomidine-13C,d3 hydrochloride is a deuterated derivative of Medetomidine, functioning primarily as a stable isotope. As a potent α2-adrenoceptor agonist with a Ki of 1.08 nM, it exhibits significant sedative and analgesic properties. Its activation of α2-adrenoceptors leads to peripheral vasoconstriction, making it valuable for pharmacological studies aimed at understanding its effects on sedation and pain management in various biological contexts. -
Stable Isotope
Clenbuterol-d9 is a deuterium-labeled derivative of Clenbuterol, a selective β2-adrenergic receptor agonist known for its potent biological activity, with an EC50 of 31.9 nM. This stable isotope serves as a valuable tool for pharmacokinetic studies and metabolic research, enabling precise tracking of drug interactions and bioavailability in various biological systems. Clenbuterol-d9 is instrumental in advancing research on β-adrenergic signaling and its implications in respiratory and metabolic disorders. -
Stable Isotope
Isoxsuprine-d6 hydrochloride is a deuterium-labeled form of Isoxsuprine hydrochloride, a selective beta-adrenergic receptor agonist. It exhibits inhibitory constants (Kis) of 13.65 μM and 3.48 μM for myometrial and placental beta-adrenergic receptors, respectively, and also functions as an NMDA receptor antagonist. This stable isotope variant is valuable for pharmacokinetic studies and metabolic tracing in biological research, facilitating an understanding of drug interactions and mechanisms of action. -
Stable Isotope
Bisoprolol-d5 is a deuterium-labeled derivative of Bisoprolol, a selective and potent β1-adrenergic receptor blocker. This compound predominantly inhibits β1-receptors with minimal β2-receptor activity, making it relevant for research in hypertension, coronary artery disease, and stable ventricular dysfunction. Bisoprolol-d5 serves as a valuable tool in pharmacokinetic studies and metabolic profiling. -
Stable Isotope
Brimonidine-d4 D-tartrate is a stable isotope-labeled form of Brimonidine D-tartrate, featuring deuterium substitution. This compound serves as an important tool for pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution in biological systems. Its incorporation in research applications can enhance the understanding of Brimonidine's mechanisms of action, particularly in the context of its use in the treatment of ocular conditions such as glaucoma. -
Stable Isotope
Acebutolol-d5 is a deuterated form of Acebutolol, specifically designed for use as a stable isotope. This compound is valuable in pharmacokinetic studies and metabolic research, enabling precise tracing of drug metabolism and distribution in biological systems. Its unique labeling makes it an essential tool for researchers investigating the pharmacological effects and metabolism of beta-blockers. -
Stable Isotope
Celiprolol-d9 hydrochloride is a deuterium-labeled derivative of Celiprolol, primarily utilized as a stable isotope. This compound serves as a valuable tool in pharmacokinetic studies, enabling the investigation of metabolic pathways and drug interactions. Researchers can leverage its unique isotopic properties for precise quantification in various biological matrices, making it essential for studies in cardiovascular pharmacology and drug development. -
Stable Isotope
Prazosin-d8 is a deuterium-labeled form of Prazosin, an alpha-adrenergic blocker that exhibits sympatholytic properties. This stable isotope is utilized in pharmacokinetic studies, providing enhanced sensitivity and specificity in metabolic profiling and drug interaction assessments. It plays a crucial role in research applications related to hypertension, anxiety disorders, PTSD, and panic disorder, aiding in the understanding of adrenergic signaling and therapeutic efficacy. -
Stable Isotope
Oxprenolol-d7 hydrochloride is a deuterium-labeled derivative of the β-adrenergic receptor antagonist, Oxprenolol. It exhibits a Ki of 7.10 nM in radioligand binding assays, demonstrating effective inhibition of β-AR activity. This stable isotope is primarily used in pharmacokinetic studies and metabolic research, facilitating investigations into the metabolism and distribution of β-adrenergic antagonists in biological systems. -
Stable Isotope
Sotalol-d6 hydrochloride is a deuterium-labeled derivative of Sotalol hydrochloride, a potent non-selective competitive β-adrenergic receptor blocker. This compound exhibits significant antiarrhythmic activity and is primarily utilized in research focused on pediatric arrhythmias. In addition to blocking β-receptors, Sotalol-d6 also inhibits potassium KCNH2 channels, providing valuable insights into cardiac electrophysiology and potential therapeutic applications. -
Stable Isotope
Brimonidine-d4 is a deuterium-labeled derivative of Brimonidine, a potent agonist of the α2-adrenergic receptor (α2-AR). This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling to trace and quantify Brimonidine in biological systems. Its applications extend to research involving ocular therapies and the modulation of neurotransmitter release through α2-AR pathways. -
Stable Isotope
Formoterol-d6 is a deuterium-labeled derivative of Formoterol, a highly selective and long-acting β2-adrenoceptor agonist. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the behavior of Formoterol in biological systems. Its incorporation into experimental designs aids in understanding drug metabolism and the pharmacological effects associated with β2-adrenoceptor activation. -
Stable Isotope
Octopamine-d4 hydrochloride is a deuterium-labeled derivative of octopamine, a biogenic monoamine related to noradrenaline. It primarily functions as a neurohormone, neuromodulator, and neurotransmitter in invertebrates. This compound has been shown to stimulate alpha2-adrenoceptors in Chinese hamster ovary cells expressing human alpha2-ARs, leading to enhanced glycogenolysis, glycolysis, oxygen uptake, and gluconeogenesis. Octopamine-d4 hydrochloride is utilized in research applications involving metabolic regulation and neurotransmitter signaling pathways. -
Stable Isotope
Phenylephrine-2,4,6-d3 hydrochloride is a stable isotope-labeled form of phenylephrine hydrochloride. It acts as a selective α1-adrenoceptor agonist, exhibiting pKis of 5.86, 4.87, and 4.70 for the α1D, α1B, and α1A receptors, respectively. This compound is utilized in pharmacological research to trace the metabolism and pharmacokinetics of phenylephrine in biological systems, enhancing the understanding of adrenergic signaling pathways. -
Stable Isotope
Yohimbine-13C,d3 is a deuterium and carbon-13 labeled version of Yohimbine, a potent and nonselective antagonist of alpha-2 adrenergic receptors. With an IC50 value of 0.6 μM, Yohimbine exhibits significant biological activity in modulating adrenergic signaling pathways. This stable isotope compound is valuable for research applications in pharmacokinetics, metabolic studies, and tracing within biological systems. -
Stable Isotope
Prazosin-d8 hydrochloride is a deuterium-labeled derivative of Prazosin hydrochloride, an alpha-adrenergic blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research, enabling precise tracking of drug metabolism and distribution. Its labeling with deuterium enhances the accuracy of analytical methods, facilitating investigations into the physiological effects of alpha-adrenergic antagonism. -
Stable Isotope
Bambuterol-d9 hydrochloride is a deuterated form of Bambuterol, a long-acting beta-adrenoceptor agonist (LABA) primarily utilized in asthma management. As a prodrug of terbutaline, it demonstrates significant bronchodilatory effects. This stable isotope compound is valuable for pharmacokinetic studies, enabling researchers to trace metabolic pathways and characterize drug behavior in biological systems. -
Stable Isotope
Terazosin-d8 is a deuterated form of Terazosin, functioning as a competitive and orally active antagonist of the α1-adrenoceptor. This compound plays a crucial role in biological research involving the modulation of vascular tone and bladder relaxation. Terazosin-d8 is particularly valuable for studies related to benign prostatic hyperplasia (BPH) and hypertension, facilitating deeper insights into mechanisms of action and pharmacokinetics through stable isotope labeling. -
Stable Isotope
Tulobuterol-d9 hydrochloride is a deuterated derivative of Tulobuterol, a long-acting β2-adrenoceptor agonist. This compound is primarily utilized as a stable isotope in pharmacokinetic studies, providing insights into the metabolic pathways and kinetics of Tulobuterol. It has demonstrated efficacy in reducing the frequency of exacerbations in chronic obstructive pulmonary disease and bronchial asthma while also enhancing diaphragm muscle strength as a sympathomimetic agent. Researchers can leverage Tulobuterol-d9 for elucidating the pharmacological properties and physiological effects of β2-adrenoceptor activation. -
Stable Isotope
Alfuzosin-d3 is a deuterium-labeled analog of Alfuzosin, primarily used as a stable isotope. This compound is significant in pharmacokinetic studies, aiding in the analysis of drug metabolism and pharmacodynamics. Its incorporation in research allows for precise tracking of Alfuzosin's biological pathways and interactions in various biological systems. -
Stable Isotope
Formoterol-d3 is a deuterium-labeled form of Arformoterol, which is the (R,R)-enantiomer of Formoterol, acting as a long-acting β2-adrenergic receptor (β2-AR) agonist with a Kd of 2.9 nM. This stable isotope allows for enhanced tracking and analysis in pharmacokinetic studies. Formoterol-d3 is primarily utilized in research relating to chronic obstructive pulmonary disease (COPD) and can aid in understanding the pharmacodynamics and metabolism of β2-AR agonists. -
Stable Isotope
Metoprolol-d7 is a deuterium-labeled form of Metoprolol, a selective β1 adrenergic receptor antagonist. It primarily targets β1 receptors to effectively manage conditions such as hypertension and heart failure. This stable isotope is useful in pharmacokinetic studies and metabolic research to trace the metabolic pathways and behavior of Metoprolol in biological systems. -
Stable Isotope
Doxazosin-d8 hydrochloride is a deuterium-labeled derivative of Doxazosin hydrochloride, primarily utilized as a stable isotope in biochemical research. This compound retains the pharmacological activity of the parent molecule, targeting alpha-1 adrenergic receptors and providing insights into receptor dynamics and drug metabolism. Its application is particularly relevant in studies involving pharmacokinetics, enabling more accurate tracking and quantification in biological systems. -
Stable Isotope
Lofexidine-d4 hydrochloride is a deuterium-labeled analog of Lofexidine hydrochloride, which selectively targets the α2-adrenergic receptor. This compound is primarily utilized in research to investigate the mechanisms underlying opioid withdrawal and the pharmacological properties of α2-agonists. Its stable isotope labeling allows for enhanced sensitivity in analytical techniques, facilitating studies in drug metabolism and receptor dynamics. -
Stable Isotope
Fenoterol-d6 hydrobromide is a deuterium-labeled analog of Fenoterol hydrobromide, a selective β2-adrenoceptor agonist. As a stable isotope, it serves as a valuable tool in pharmacokinetic studies and metabolic research. Fenoterol hydrobromide is known for its bronchodilator activity, making it relevant in investigations related to asthma, bronchitis, and other obstructive airway diseases. This isotopically labeled compound can enhance the understanding of β2-adrenergic signaling and drug metabolism in various biological assays. -
Stable Isotope
(Rac)-Timolol-d5 maleate is a labeled stable isotope of racemic (S)-Timolol maleate, a non-cardioselective β-adrenoceptor antagonist. This compound effectively reduces intraocular pressure and is commonly employed in the management of glaucoma by inhibiting aqueous humor production. Additionally, it finds applications in the treatment of hypertension, angina pectoris, and myocardial infarction, making it a valuable tool for cardiovascular research and ophthalmic studies. -
Stable Isotope
Bufuralol-d9 hydrochloride is a deuterated form of Bufuralol hydrochloride, serving as a stable isotope. Its primary mechanism involves selective beta-adrenergic receptor antagonism, which is crucial for research involving pharmacokinetics and metabolic studies. This reagent is particularly useful in tracing and quantifying drug metabolism and interactions in biological systems, facilitating advanced studies in cardiovascular and pharmacological research. -
Stable Isotope
(S)-Metoprolol-d7 is a deuterated form of Metoprolol, a selective β1-adrenergic receptor antagonist. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and drug metabolism research, providing insights into the pharmacological properties of Metoprolol in cardiovascular applications, particularly in hypertension treatment. Its incorporation of deuterium allows for enhanced tracking and analysis in various analytical techniques. -
Stable Isotope
(S)-Atenolol-d7 is a deuterium-labeled analog of (S)-Atenolol, primarily utilized as a stable isotope. This compound serves as a valuable tool in pharmacokinetic studies and metabolic profiling, allowing for precise tracking of drug metabolism and distribution in biological systems. (S)-Atenolol-d7 is particularly advantageous for researchers investigating cardiovascular pharmacology and drug interactions involving beta-adrenergic blockers. -
Stable Isotope
Phenoxybenzamine-d5 hydrochloride is the deuterated analog of Phenoxybenzamine hydrochloride, a nonselective, irreversible α-adrenoceptor antagonist. This reagent is primarily utilized in research related to hypertension, particularly in cases caused by pheochromocytoma. Additionally, Phenoxybenzamine hydrochloride exhibits antitumor activity, making it relevant for studies in cancer biology and therapeutic development. -
Stable Isotope
Atomoxetine-d3 hydrochloride is a deuterium-labeled derivative of Atomoxetine hydrochloride, a potent and selective norepinephrine reuptake inhibitor. It exhibits binding affinities with Ki values of 5 nM for the human norepinephrine transporter, 77 nM for the serotonin transporter, and 1451 nM for the dopamine transporter. This stable isotope is invaluable for pharmacokinetic studies, tracer experiments, and understanding the metabolic pathways of noradrenergic agents in chemical research. -
Stable Isotope
Alfuzosin-d3 hydrochloride is a deuterated form of Alfuzosin hydrochloride, targeting α1 adrenergic receptors. This stable isotope is utilized primarily in pharmacokinetic studies and drug metabolism research, enabling precise tracking of drug behavior in biological systems. It is particularly relevant in studies involving benign prostatic hyperplasia (BPH) therapies. -
Stable Isotope
(R)-Metoprolol-d7 is a deuterium-labeled analog of Metoprolol, a selective β1 adrenergic receptor antagonist. This stable isotope is essential for pharmacokinetic studies and metabolic research, allowing for precise tracking and quantification of Metoprolol in biological systems. It is particularly valuable in investigations related to cardiovascular diseases, including hypertension and heart failure. -
Stable Isotope
Nomifensine-d3 maleate is a deuterium-labeled derivative of Nomifensine maleate, a potent inhibitor of norepinephrine (NE) and dopamine (DA) reuptake. It effectively blocks the reuptake of NE, DA, and serotonin (5-HT) in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM, and 830 nM, respectively. This compound displays antidepressant and analgesic properties, and is applicable in research related to neurodegenerative diseases, substance addiction, and pain mechanisms. -
Stable Isotope
Prazobind-d8 is a deuterium-labeled analog of Prazobind, functioning as an irreversible antagonist of the α1-adrenoceptor. With an IC50 value of 1 nM, Prazobind-d8 exhibits potent competitive binding to α1-adrenoceptor subtypes, specifically in the hippocampus and liver. This compound partially inhibits contractions in smooth, circular, and longitudinal muscle tissues, making it a valuable tool for investigating mechanisms related to blood pressure regulation and related cardiovascular research. -
Stable Isotope
Clonidine-d4 hydrochloride is a deuterium-labeled analog of Clonidine, an alpha-2 adrenergic agonist. This stable isotope is valuable for pharmacokinetic studies and metabolic research, providing enhanced sensitivity and specificity in mass spectrometry analyses. Its applications include elucidating drug metabolism, developing analytical methods, and studying adrenergic signaling pathways. -
Stable Isotope
Medetomidine-d3 hydrochloride is a deuterated form of Medetomidine hydrochloride, targeting adrenergic alpha-2 receptors as an agonist. This stable isotope is useful for pharmacokinetic studies, enabling researchers to trace metabolic pathways and evaluate the efficacy of alpha-2 adrenergic receptor modulation in various biological systems. Its application is particularly valuable in drug discovery and development involving sedative and analgesic compounds. -
Stable Isotope
(Rac)-Tamsulosin-d3 hydrochloride is a deuterium-labeled variant of (Rac)-Tamsulosin hydrochloride, functioning as a stable isotope. This compound is designed for use in pharmacokinetic studies, allowing researchers to trace and quantify the metabolism and distribution of Tamsulosin in biological systems. Its stable isotope labeling facilitates accurate detection and analysis in various biological assays, making it an essential tool for drug metabolism research.
