Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Pregnenolone monosulfate-d4 sodium is a deuterated form of pregnenolone monosulfate sodium, a neurosteroid and precursor for steroid hormone synthesis. It selectively inhibits cannabinoid CB1 receptors, thereby attenuating the psychoactive effects of tetrahydrocannabinol (THC) and offering neuroprotective properties against cannabis intoxication. Additionally, this compound activates the TRPM3 channel while displaying weak activation of TRPM1 channels, making it a valuable tool for research in neurobiology and cannabinoid signaling pathways. -
Stable Isotope
Amiodarone-d10 hydrochloride is a deuterium-labeled derivative of Amiodarone. This compound acts primarily as an antiarrhythmic agent, exerting its effects through the inhibition of ATP-sensitive potassium channels, with an IC50 value of 19.1 μM. It is utilized in pharmacokinetic studies and research focused on cardiovascular diseases, providing insights into drug metabolism and action mechanisms. -
Stable Isotope
Sulfabenzamide-d4 is a deuterated analog of Sulfabenzamide, a sulfonamide antimicrobial agent that demonstrates efficacy against both Gram-positive and Gram-negative bacterial strains. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace the compound's behavior in biological systems. Sulfabenzamide-d4 serves as a valuable tool for researchers investigating the pharmacodynamics and pharmacokinetics of sulfonamide antibiotics. -
Stable Isotope
Indomethacin-d4 is a deuterium-labeled form of Indomethacin, known as a potent, nonselective inhibitor of cyclooxygenase isoforms COX-1 and COX-2. It exhibits blood-brain barrier permeability, with reported IC50 values of 18 nM for human COX-1 and 26 nM for COX-2 in CHO cells. This compound is utilized in research to study anti-inflammatory pathways and examine the effects on autophagic flux through lysosomal disruption. -
Stable Isotope
Homovanillic acid-d2 is a deuterium-labeled derivative of Homovanillic acid, serving as a stable isotope. This compound is a critical dopamine metabolite linked to various metabolic disorders, including aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. It is utilized in metabolic studies and biomarker research to trace dopamine metabolism and related biochemical pathways. -
Stable Isotope
Ivacaftor-d19 is a stable isotope variant of the established CFTR modulator, Ivacaftor. It demonstrates effective potentiation of the CFTR protein, exhibiting an EC50 value of 255 nM in G551D/F508del human bronchial epithelial cells. This deuterated analog serves as a valuable tool for cystic fibrosis research, enabling detailed studies of CFTR function and pharmacological modulation. -
Stable Isotope
Homovanillic acid-13C6,18O is a stable isotope-labeled form of Homovanillic acid, a key dopamine metabolite. This compound is crucial for studying various metabolic disorders, including aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. Its isotopic labeling enables precise tracking in metabolic studies, enhancing research applications in neurobiology and related fields. -
Stable Isotope
Rosuvastatin-d6 sodium is a deuterated form of Rosuvastatin sodium, a competitive inhibitor of HMG-CoA reductase (HMGCR) with an IC50 of 11 nM. This reagent not only inhibits cholesterol synthesis but also significantly reduces low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. In addition, Rosuvastatin-d6 sodium affects hERG current conductance and diminishes the interaction between heat shock protein 70 (Hsp70) and hERG protein, making it valuable for studies focused on lipid metabolism and cardiac ion channel function. -
Stable Isotope
Pentoxifylline-d5 is a deuterated form of Pentoxifylline, a non-selective phosphodiesterase (PDE) inhibitor known for its haemorheological properties. It exhibits various biological activities, including immune modulation, anti-inflammatory, anti-fibrinolytic, and anti-proliferation effects. This stable isotope is useful for metabolic studies and research involving peripheral vascular disease, cerebrovascular disease, and conditions associated with impaired regional microcirculation. -
Stable Isotope
ZLN005-d4 is a deuterium-labeled derivative of ZLN005, designed for advanced chemical research applications. This compound functions as a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), influencing metabolic processes and energy homeostasis. It is primarily utilized in studies investigating metabolic disorders and cellular energy regulation. -
Stable Isotope
Telmisartan-d7 is a stable isotope-labeled derivative of Telmisartan, a potent and long-acting antagonist of the angiotensin II type 1 receptor (AT1). By selectively inhibiting the binding of 125I-AngII to AT1 receptors with an IC50 of 9.2 nM, Telmisartan-d7 serves as a valuable tool for pharmacokinetic studies and the investigation of receptor interactions in biological systems. Its use in research may further elucidate the role of AT1 receptor modulation in cardiovascular and renal pathologies. -
Stable Isotope
6-Mercaptopurine-13C2,15N is a stable isotope-labeled derivative of 6-Mercaptopurine, specifically incorporating two carbon-13 and one nitrogen-15 atoms. This purine analogue functions as an antagonist to endogenous purines, making it valuable in the treatment of leukemia and as an immunosuppressive agent. Its isotopic labeling allows for enhanced tracking and metabolic studies in biological research, contributing to insights into purine metabolism and drug interactions. -
Stable Isotope
Pravastatin-d3 sodium is a deuterated form of pravastatin sodium salt, serving as a stable isotope for research applications. This compound acts as a competitive inhibitor of HMG-CoA reductase, playing a crucial role in the regulation of sterol synthesis, with an IC50 value of 5.6 μM. Pravastatin-d3 sodium is utilized in metabolic studies, pharmacokinetics, and to trace the metabolic pathways of cholesterol-lowering agents. -
Stable Isotope
Ammonium chloride-d4 is a deuterated form of ammonium chloride, serving as a stable isotope for biochemical studies. This compound functions as a heteropolar agent, regulating pH levels while inducing intracellular alkalization and metabolic acidosis, thus impacting enzymatic activity and biological processes. Ammonium chloride-d4 is recognized for its role as an autophagy and lysosome inhibitor, making it a valuable tool in various research applications related to cellular metabolism and autophagy pathways. -
Stable Isotope
Methylprednisolone-d3-1 is a deuterium-labeled derivative of Methylprednisolone, a synthetic corticosteroid known for its anti-inflammatory and immunomodulatory activities. This compound plays a pivotal role in biological research by serving as a stable isotope for tracing studies. Its applications extend to investigating the therapeutic effects on severe or critical COVID-19, where it helps activate ACE2 and decrease IL-6 levels, thus contributing to respiratory health research and cytokine regulation studies. -
Stable Isotope
Ixazomib-d7 is a deuterium-labeled derivative of Ixazomib, a selective and potent reversible proteasome inhibitor. It primarily targets the chymotrypsin-like (β5) site of the 20S proteasome, demonstrating an IC50 of 3.4 nM and a Ki of 0.93 nM. This stable isotope is valuable for tracking metabolic processes and investigating proteasome inhibition in various biological contexts, making it an essential tool in cancer research and drug development. -
Stable Isotope
Efavirenz-13C6 is a stable isotope-labeled variant of Efavirenz, a strong inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki of 2.93 nM. This compound demonstrates an IC95 of 1.5 nM, effectively inhibiting the replication of HIV-1 in cultured cells. Efavirenz-13C6 is valuable for studies in pharmacokinetics, metabolism, and HIV research applications requiring precise tracking of drug distribution and activity. -
Stable Isotope
Pentoxifylline-d6 is a deuterium-labeled analog of Pentoxifylline, a non-selective phosphodiesterase (PDE) inhibitor. This compound exhibits haemorheological properties along with immune modulation, anti-inflammatory, anti-fibrinolytic, and anti-proliferative activities. Pentoxifylline-d6 serves as a valuable tool in research focused on peripheral vascular disease, cerebrovascular disease, and various conditions characterized by impaired regional microcirculation. Its stable isotope labeling allows for advanced studies using mass spectrometry and other analytical techniques. -
Stable Isotope
Rimantadine-d4 hydrochloride is a stable isotope-labeled derivative of Rimantadine hydrochloride. It specifically targets the M2 protein of influenza viruses, functioning as an inhibitor that blocks hydrogen ion channel activity. This compound effectively prevents viral entry and replication, showcasing broad-spectrum antiviral activity. Rimantadine-d4 hydrochloride can be utilized in virology research to study influenza virus mechanisms and antiviral drug development. -
Stable Isotope
Cilostazol-d11 is a deuterated form of Cilostazol, a potent and selective inhibitor of phosphodiesterase 3A (PDE 3A). This compound exhibits an IC50 of 0.2 μM, making it a valuable tool for cardiovascular research. Cilostazol-d11 can be utilized in studies investigating PDE 3A inhibition, its implications in vasodilation, and various cardiovascular disorders. -
Stable Isotope
Amoxapine-d8 is a deuterium-labeled derivative of Amoxapine, a compound known for its role as a norepinephrine reuptake inhibitor and 5-HT2/5-HT3 receptor antagonist. This stable isotope is valuable for pharmacokinetic studies and metabolic research involving depression and other neuropsychiatric disorders. Additionally, Amoxapine has demonstrated antibacterial activity and can enhance macrophage-mediated killing of mycobacterium through autophagy induction while providing cytoprotection. -
Stable Isotope
Carvedilol-d3 is a deuterium-labeled analogue of Carvedilol, functioning primarily as a non-selective β/α-1 adrenergic receptor blocker. It exhibits significant biological activity by inhibiting lipid peroxidation in a dose-dependent manner with an IC50 value of 5 μM. This compound serves as a versatile antihypertensive agent and has potential applications in the treatment of angina and congestive heart failure. Furthermore, Carvedilol-d3 promotes autophagy and is known to inhibit the NLRP3 inflammasome, making it valuable for research involving inflammatory processes. -
Stable Isotope
(R)-(-)-Felodipine-d5 is a deuterium-labeled analogue of the S enantiomer of Felodipine, a potent vasoselective calcium channel antagonist. This compound effectively lowers blood pressure through its selective action on vascular smooth muscle, particularly in resistance vessels. In addition to its antihypertensive properties, Felodipine has been shown to induce autophagy and is capable of crossing the blood-brain barrier. It is suitable for research applications involving pharmacokinetics and metabolic studies of calcium channel blockers. -
Stable Isotope
Indomethacin-d4 Methyl Ester is a deuterium-labeled analog of indomethacin, a potent and nonselective inhibitor of cyclooxygenase (COX) enzymes. It exhibits significant inhibitory activity with IC50 values of 18 nM for human COX-1 and 26 nM for COX-2 in CHO cells. This compound disrupts autophagic flux by impairing lysosomal function, making it a valuable tool for studying inflammation and autophagy in various biological contexts. Its stable isotope labeling enables precise tracking and quantification in metabolic and pharmacokinetic studies. -
Stable Isotope
Nimodipine-d7 is a deuterium-labeled form of Nimodipine, a dihydropyridine calcium channel blocker known for its oral bioavailability and tolerability. This stable isotope is particularly useful in pharmacokinetic studies and tracer applications, facilitating the investigation of cerebrovascular disorders. Researchers can employ Nimodipine-d7 to enhance the understanding of calcium modulation within neuronal contexts, contributing significant insights into therapeutic strategies for cerebrovascular conditions. -
Stable Isotope
Megestrol acetate-d3 is a deuterium-labeled derivative of the synthetic progesterone analog, Megestrol acetate. This compound primarily acts as an appetite stimulant, making it valuable in the study of wasting syndromes, including cachexia. Additionally, Megestrol acetate has been shown to inhibit androgen receptor signaling in human benign prostatic hyperplasia (BPH) tissue and may be applicable in HIV research, as it downregulates the autophagic catabolic pathway. This stable isotope can provide insights into pharmacokinetics and metabolism of Megestrol acetate in various biological systems. -
Stable Isotope
Bicalutamide-d4 is a deuterium-labeled derivative of Bicalutamide, a potent non-steroidal androgen receptor (AR) antagonist. This stable isotope serves as a valuable tool for studying the pharmacokinetics and metabolism of Bicalutamide in prostate cancer research. Its unique labeling assists in tracing and quantifying drug interactions and biological activity in various experimental settings. -
Stable Isotope
Topotecan-d5 is a deuterium-labeled derivative of Topotecan, a potent inhibitor of Topoisomerase I. It exhibits notable inhibitory activity with IC50 values of 2.73±0.25 μM in U251 cells, 2.95±0.23 μM in U87 cells, and 5.46±0.41 μM and 5.95±0.24 μM in glioblastoma stem cells GSCs-U251 and GSCs-U87, respectively. This stable isotope-labeled reagent is valuable for drug metabolism studies and pharmacokinetic research, enhancing the understanding of Topotecan’s mechanism of action in cancer therapy. -
Stable Isotope
6-Mercaptopurine-d2 is a deuterium-labeled derivative of 6-Mercaptopurine, a purine analog that functions as an antagonist to endogenous purines. This compound exhibits significant antileukemic and immunosuppressive properties. It is particularly useful in research applications involving drug metabolism and pharmacokinetics, allowing for precise tracking of 6-Mercaptopurine in biological systems. -
Stable Isotope
Obeticholic acid-d5 is a deuterated derivative of Obeticholic acid, a selective and orally active agonist of the farnesoid X receptor (FXR) with an EC50 of 99 nM. This compound exhibits significant anticholeretic and anti-inflammatory effects, making it valuable in studies related to liver diseases. Additionally, Obeticholic acid is known to induce autophagy, highlighting its potential for research into metabolic regulation and cellular homeostasis. -
Stable Isotope
Carbamazepine-d2 is a deuterium-labeled derivative of Carbamazepine, a sodium channel blocker commonly used as an anticonvulsant agent. This stable isotope facilitates tracking and quantification studies of Carbamazepine in biological systems. Its application in research includes pharmacokinetic studies, metabolite profiling, and drug interaction assessments. -
Stable Isotope
Cabergoline-d5 is a deuterium-labeled derivative of Cabergoline, which functions as a selective agonist for dopamine D2-like receptors. It exhibits high affinity for D2, D3, and 5-HT2B receptors, with Ki values of 0.7, 1.5, and 1.2 nM, respectively. This stable isotope is utilized in research focused on neuropharmacology and the study of dopaminergic signaling pathways. -
Stable Isotope
AICAR-13C2,15N is a stable isotope-labeled form of AICAR (also known as Acadesine or AICA Riboside), which acts as an adenosine analog and a powerful AMPK activator. This compound plays a critical role in regulating glucose and lipid metabolism, while also inhibiting pro-inflammatory cytokine production and inducible nitric oxide synthase (iNOS). Additionally, AICAR-13C2,15N serves as an inhibitor of autophagy, YAP, and mitophagy, making it a valuable reagent for studying metabolic pathways and cellular responses in various research applications. -
Stable Isotope
Cilostazol-d4 is a deuterium-labeled derivative of Cilostazol, a selective inhibitor of phosphodiesterase 3A (PDE3A) with an IC50 of 0.2 μM. This stable isotope-labeled compound is widely used in pharmacokinetic studies and metabolic research to trace biological pathways and evaluate the pharmacological effects of Cilostazol. Its specificity for PDE3A makes it a valuable tool for investigating cardiovascular functions and related disease mechanisms. -
Stable Isotope
Fenofibrate-d4 is a deuterium-labeled form of Fenofibrate, a selective agonist of the peroxisome proliferator-activated receptor alpha (PPARα) with an EC50 value of 30 μM. This compound also demonstrates inhibitory effects on various human cytochrome P450 isoforms, with IC50 values of 0.2 μM for CYP2C19, 0.7 μM for CYP2B6, 9.7 μM for CYP2C9, 4.8 μM for CYP2C8, and 142.1 μM for CYP3A4. Fenofibrate-d4 is useful in pharmacokinetic studies, metabolic research, and in experiments requiring isotopically labeled compounds for tracer studies. -
Stable Isotope
Pregnenolone-13C2,d2 is a stable isotope-labeled form of Pregnenolone, which serves as a critical precursor for various steroid hormones. This neurosteroid functions as a selective inhibitor of the cannabinoid CB1 receptor, mitigating the effects of tetrahydrocannabinol (THC) associated with CB1 receptor activation. Additionally, Pregnenolone-13C2,d2 is recognized for its ability to activate the TRPM3 channel and demonstrates weak activity on TRPM1 channels. Its unique isotopic labeling makes it a valuable tool for research applications in neuropharmacology and steroid biochemistry. -
Stable Isotope
Rosuvastatin-d3 is a stable isotope-labeled form of Rosuvastatin, a potent competitive inhibitor of HMG-CoA reductase, demonstrating an IC50 of 11 nM. This compound also significantly inhibits the human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Research applications include studying cholesterol biosynthesis, cardiac repolarization, and the effects of statins on action potential durations and corrected QT intervals in cardiac tissues. -
Stable Isotope
Ulipristal acetate-d6 is a deuterated form of Ulipristal acetate, a selective progesterone receptor modulator (SPRM). It is known to selectively stimulate the autophagic response in leiomyoma cells. This compound is significant in research related to benign gynecological conditions, particularly for its potential therapeutic applications in treating uterine myoma. -
Stable Isotope
Carprofen-13C,d3 is a stable isotope-labeled form of Carprofen, a non-steroidal anti-inflammatory drug. This compound functions primarily as a multi-target inhibitor of fatty acid amide hydrolase (FAAH) and cyclooxygenases (COX), demonstrating IC50 values of 3.9 μM for COX-2, 22.3 μM for COX-1, and 78.6 μM for FAAH. Carprofen-13C,d3 is valuable for research applications requiring isotopic labeling, enabling precise studies of drug metabolism and pharmacokinetics. -
Stable Isotope
Pemetrexed-d5 is a deuterium-labeled analog of Pemetrexed, an antifolate agent. This compound effectively inhibits key enzymes involved in nucleotide synthesis, demonstrating Ki values of 1.3 nM, 7.2 nM, and 65 nM for thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. Pemetrexed-d5 is valuable for metabolic studies and tracer applications in cancer research, providing insights into drug mechanisms and pharmacokinetics. -
Stable Isotope
Trifluoperazine-d3 dihydrochloride is a deuterated derivative of Trifluoperazine, primarily targeting dopamine receptors to exert its antipsychotic effects. This compound is a potent α1-adrenergic receptor antagonist and an effective inhibitor of NUPR1, showcasing anticancer properties. Additionally, it functions as a calmodulin inhibitor and can interfere with P-glycoprotein activity. Trifluoperazine-d3 dihydrochloride is valuable for research applications related to schizophrenia and serves as a reversible inhibitor of influenza virus morphogenesis. -
Stable Isotope
Mifepristone-d6 is a deuterated form of Mifepristone, a potent antagonist of the progesterone receptor (PR) and the glucocorticoid receptor (GR), exhibiting IC50 values of 0.2 nM and 2.6 nM, respectively, in in vitro assays. This stable isotope-labeled compound serves as a valuable tool for metabolic studies, pharmacokinetic investigations, and research on receptor interactions. Its unique isotopic signature allows for precise tracking and analysis in biological systems, facilitating advanced research in endocrinology and reproductive health. -
Stable Isotope
Niacin-15N,13C3 is a stable isotope-labeled form of Niacin (Vitamin B3), containing both 13C and 15N isotopes. Niacin is an essential water-soluble vitamin that plays a crucial role in energy metabolism and regulates cellular signaling pathways that influence gene expression and apoptosis. This reagent is particularly useful in research focusing on metabolic processes and cardiovascular diseases, providing insights into the biochemical pathways associated with these areas. -
Stable Isotope
Vemurafenib-d7 is a deuterium-labeled derivative of Vemurafenib, a selective and potent inhibitor of B-RAF kinase, demonstrating IC50 values of 31 nM for RAFV600E and 48 nM for c-RAF-1. This compound is instrumental in studying the pharmacokinetics and metabolism of Vemurafenib in biological systems. Additionally, it is useful in research applications involving cell autophagy and targeted cancer therapies. -
Stable Isotope
Yangonin-d3 is a deuterium-labeled derivative of Yangonin, acting as a stable isotope. This compound demonstrates binding affinity for the human recombinant cannabinoid CB1 receptor, with an IC50 of 1.79 μM and a Ki of 0.72 μM. Yangonin-d3 is valuable for research applications in cannabinoid receptor studies, enabling the exploration of receptor mechanisms and the development of cannabinoid-based therapeutics. -
Stable Isotope
Carvedilol-d5 is a deuterium-labeled analogue of Carvedilol, a non-selective β/α-1 adrenergic receptor blocker. It exhibits lipid peroxidation inhibition with an IC50 of 5 μM and serves as a versatile antihypertensive agent, showing potential in the treatment of angina and congestive heart failure. Additionally, Carvedilol functions as an autophagy inducer and inhibits the NLRP3 inflammasome, making it relevant for research in inflammatory pathways and cardiovascular health. -
Stable Isotope
Rel-Paroxetine-d4 hydrochloride is a stable isotope-labeled derivative of rel-Paroxetine hydrochloride. This compound serves as a valuable tool for pharmacokinetic and metabolic studies, helping to elucidate the mechanism of action and biological pathways of selective serotonin reuptake inhibitors (SSRIs). It facilitates the development of analytical methods to track the fate of rel-Paroxetine in biological systems, enhancing research in fields such as psychiatry and neuropharmacology. -
Stable Isotope
Homovanillic acid-d3-1 is a deuterated form of Homovanillic acid, serving as a stable isotope for research applications. It acts as a metabolite of dopamine and is implicated in various clinical conditions, including aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. This isotopic labeling is valuable for studies involving metabolic pathways and neurochemical analysis. -
Stable Isotope
Bexarotene-13C4 is a stable isotope-labeled analog of Bexarotene, a high-affinity selective agonist of retinoid X receptors (RXR). It demonstrates potent activity with EC50 values of 33, 24, and 25 nM for RXRα, RXRβ, and RXRγ, respectively, while exhibiting minimal affinity for RAR receptors (EC50 >10000 nM). This compound is primarily utilized in research related to cutaneous T-cell lymphoma, enhancing studies involving RXR-mediated signaling pathways. -
Stable Isotope
Omeprazole-d3-1 is a deuterium-labeled form of Omeprazole, a proton pump inhibitor (PPI) primarily targeting acid-related gastrointestinal disorders. This compound exhibits competitive inhibition of CYP2C19, with a Ki ranging from 2 to 6 μM, and has demonstrated antimicrobial effects against both Gram-positive and Gram-negative bacteria. Additionally, Omeprazole acts as a potent inhibitor of neutral sphingomyelinase (N-SMase), impacting exosome production in cell studies. This stable isotope is a valuable tool for pharmacokinetic and metabolic research applications.
