Fig. 1 · Structure
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Lipoxin A4-d5
Stable Isotope
Lipoxin A4-d5 is the deuterium-labeled form of Lipoxin A4, a naturally occurring eicosanoid derived from lipoxygenase. This compound exhibits significant pro-resolving and anti-inflammatory properties, effectively inhibiting the proliferation of human epidermal keratinocytes and the production of inflammatory cytokines and chemokines through the ERK1/2 and NF-kB pathways. Lipoxin A4 also reduces IL-8 release mediated by serum amyloid A (SAA), demonstrating an IC50 value of 25.74 nM. Lipoxin A4-d5 serves as a valuable tool in research aimed at understanding inflammation resolution and related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1622429-53-1 |
| Applications | Stable Isotope |
| Formula | C20H27D5O5 |
| Molecular Weight | 357.50 |
| Synonyms | LXA4-d5 |
| SMILES | O[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(O)=O)O)O)CCCC([2H])(C([2H])([2H])[2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.