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Sulindac sulfide-d3

Stable Isotope

Sulindac sulfide-d3 is a deuterium-labeled derivative of Sulindac sulfide, primarily known for its role as a noncompetitive inhibitor of γ-secretase. This compound exhibits an IC50 of 20.2 μM for inhibiting γ42-secretase activity, making it a valuable tool in the study of Alzheimer’s disease and related pathologies. Applications include investigations into the biochemical pathways involved in amyloid precursor protein processing and the modulation of signaling pathways associated with γ-secretase activity.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	250608-66-3
Applications	Stable Isotope
Formula	C₂₀H₁₄D₃FO₂S
Molecular Weight	343.43
Synonyms	cis-Sulindac sulfide-d3
SMILES	OC(CC1=C(C)/C(C2=CC=C(F)C=C21)=C/C3=CC=C(C=C3)SC([2H])([2H])[2H])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.