N-Desmethylclozapine-d8 is a deuterium-labeled analogue of N-Desmethylclozapine, a significant active metabolite of the atypical antipsychotic clozapine. This compound serves as a potent partial agonist at M1 receptors (EC50 = 115 nM), effectively enhancing hippocampal NMDA receptor currents through M1 receptor activation. Additionally, it functions as a δ-opioid agonist, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychiatric disorders.
N-Desmethylclozapine-d8 is a deuterium-labeled analogue of N-Desmethylclozapine, a significant active metabolite of the atypical antipsychotic clozapine. This compound serves as a potent partial agonist at M1 receptors (EC50 = 115 nM), effectively enhancing hippocampal NMDA receptor currents through M1 receptor activation. Additionally, it functions as a δ-opioid agonist, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychiatric disorders.
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