Fig. 1 · Structure
Documents & Downloads
Palbociclib-d4
Stable Isotope
Palbociclib-d4 is a stable isotope-labeled form of Palbociclib, a selective inhibitor of CDK4 and CDK6, demonstrating IC50 values of 11 and 16 nM respectively. This compound exhibits strong anti-proliferative effects and effectively induces cell cycle arrest in cancer cells. Palbociclib-d4 is primarily utilized in research related to hormone receptor-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1628752-63-5 |
| Applications | Stable Isotope |
| Formula | C24H25D4N7O2 |
| Molecular Weight | 451.56 |
| Synonyms | PD 0332991-d4 |
| SMILES | O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CC([2H])(NC([2H])(C5)[2H])[2H])C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.