Fig. 1 · Structure
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Methotrexate metabolite-d3
Stable Isotope
Methotrexate metabolite-d3 is a deuterium-labeled form of the active Methotrexate metabolite known as DAMPA. This compound serves as a folic acid antagonist, playing a crucial role in inhibiting dihydrofolate reductase, which is critical for nucleotide synthesis. Methotrexate metabolite-d3 is utilized in various research applications, including pharmacokinetic studies and metabolic profiling, to better understand the dynamics of Methotrexate metabolism and its therapeutic effects.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1794780-00-9 |
| Applications | Stable Isotope |
| Formula | C15H12D3N7O2 |
| Molecular Weight | 328.34 |
| Synonyms | DAMPA-d3 |
| SMILES | NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(O)=O)C([2H])([2H])[2H])C=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.