Fig. 1 · Structure
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Palbociclib-d8
Stable Isotope
Palbociclib-d8 is a deuterated form of Palbociclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), showing IC50 values of 11 nM and 16 nM, respectively. This isotopically labeled compound allows for detailed pharmacokinetic studies and metabolic profiling. Palbociclib-d8 is particularly relevant in research on ER-positive and HER2-negative breast cancer, facilitating investigations into its mechanisms of action and therapeutic efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1628752-83-9 |
| Applications | Stable Isotope |
| Formula | C24H21D8N7O2 |
| Molecular Weight | 455.58 |
| Synonyms | PD 0332991-d8 |
| SMILES | O=C1N(C2=NC(NC3=NC=C(C=C3)N4C([2H])(C([2H])(NC([2H])(C4([2H])[2H])[2H])[2H])[2H])=NC=C2C(C)=C1C(C)=O)C5CCCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.