Fig. 1 · Structure
Documents & Downloads
Ribociclib-d8
Stable Isotope
Ribociclib-d8 is a deuterated form of Ribociclib, a selective inhibitor of CDK4 and CDK6. It demonstrates potent inhibitory activity with IC50 values of 10 nM for CDK4 and 39 nM for CDK6, while exhibiting over a 1,000-fold reduced potency against the cyclin B/CDK1 complex. This stable isotope-labeled compound is ideal for applications in pharmacokinetic studies, drug metabolism research, and metabolic profiling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2167898-24-8 |
| Applications | Stable Isotope |
| Formula | C23H22D8N8O |
| Molecular Weight | 442.59 |
| Synonyms | LEE011-d8 |
| SMILES | CN(C)C(C(N(C1CCCC1)C2=N3)=CC2=CN=C3NC4=CC=C(N5C([2H])([2H])C([2H])([2H])NC([2H])([2H])C5([2H])[2H])C=N4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.