7α,25-Dihydroxycholesterol-d6

Catalog No.: A60235
Stable Isotope
7α,25-Dihydroxycholesterol-d6 is a deuterated form of 7α,25-Dihydroxycholesterol, functioning as a selective agonist and endogenous ligand for the orphan G protein-coupled receptor EBI2 (GPR183). This stable isotope is crucial for studies involving lipid metabolism and immune response, particularly in relation to the modulation of B cell trafficking. Researchers utilize 7α,25-Dihydroxycholesterol-d6 in various biochemical assays to elucidate signaling pathways mediated by EBI2.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description7α,25-Dihydroxycholesterol-d6 is a deuterated form of 7α,25-Dihydroxycholesterol, functioning as a selective agonist and endogenous ligand for the orphan G protein-coupled receptor EBI2 (GPR183). This stable isotope is crucial for studies involving lipid metabolism and immune response, particularly in relation to the modulation of B cell trafficking. Researchers utilize 7α,25-Dihydroxycholesterol-d6 in various biochemical assays to elucidate signaling pathways mediated by EBI2.
Product Information
Catalog NumA60235
FormulaC27H40D6O3
Molecular Weight424.69
CAS Number2260669-11-0
SMILESC[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@H]3O)C
Synonyms7α,25-OHC-d6
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