Siponimod-d11 is a deuterium-labeled derivative of Siponimod, a selective modulator of sphingosine-1-phosphate (S1P) receptors. This compound exhibits preferential binding to the S1P1 and S1P5 receptors with EC50 values of 0.4 and 0.98 nM, respectively, while showing significantly lower affinity for S1P2, S1P3, and S1P4. Siponimod-d11 is a valuable tool in the research of multiple sclerosis, aiding in the understanding of S1P receptor signaling and its therapeutic implications.
Siponimod-d11 is a deuterium-labeled derivative of Siponimod, a selective modulator of sphingosine-1-phosphate (S1P) receptors. This compound exhibits preferential binding to the S1P1 and S1P5 receptors with EC50 values of 0.4 and 0.98 nM, respectively, while showing significantly lower affinity for S1P2, S1P3, and S1P4. Siponimod-d11 is a valuable tool in the research of multiple sclerosis, aiding in the understanding of S1P receptor signaling and its therapeutic implications.
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