Raclopride-d5 hydrochloride is a deuterium-labeled derivative of Raclopride, a selective antagonist for dopamine D2 and D3 receptors. It exhibits high affinity, with dissociation constants (Kis) of 1.8 nM for D2 and 3.5 nM for D3 receptors, while demonstrating minimal interaction with D1 and D4 receptors (Kis of 18000 nM and 2400 nM, respectively). This compound is valuable in neuropharmacology research for studying dopamine signaling pathways and receptor mechanisms in various models.
Raclopride-d5 hydrochloride is a deuterium-labeled derivative of Raclopride, a selective antagonist for dopamine D2 and D3 receptors. It exhibits high affinity, with dissociation constants (Kis) of 1.8 nM for D2 and 3.5 nM for D3 receptors, while demonstrating minimal interaction with D1 and D4 receptors (Kis of 18000 nM and 2400 nM, respectively). This compound is valuable in neuropharmacology research for studying dopamine signaling pathways and receptor mechanisms in various models.
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