Desmethyl cariprazine-d8 is a deuterium-labeled analog of desmethyl cariprazine, a prominent active metabolite of cariprazine. This compound demonstrates significant affinity for human dopamine D2 and D3 receptors, with pEC50 values of 8.90 and 8.09, respectively, as well as a pEC50 of 6.28 at serotonin 5-HT1A receptors. Desmethyl cariprazine-d8 effectively inhibits forskolin-induced cAMP production and suppresses serotonin-induced Ca2+ release at the 5-HT2B receptor. Its utility is particularly relevant in research focused on mental health disorders such as schizophrenia and bipolar disorder type I.
Desmethyl cariprazine-d8 is a deuterium-labeled analog of desmethyl cariprazine, a prominent active metabolite of cariprazine. This compound demonstrates significant affinity for human dopamine D2 and D3 receptors, with pEC50 values of 8.90 and 8.09, respectively, as well as a pEC50 of 6.28 at serotonin 5-HT1A receptors. Desmethyl cariprazine-d8 effectively inhibits forskolin-induced cAMP production and suppresses serotonin-induced Ca2+ release at the 5-HT2B receptor. Its utility is particularly relevant in research focused on mental health disorders such as schizophrenia and bipolar disorder type I.
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