Catalog No.
Product Name
Application
Product Information
Citations
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HIV Protease Inhibitor
R-87366 is a water-soluble inhibitor of HIV protease, demonstrating potent inhibition with a Ki value of 11 nM. This compound is instrumental in the study of human immunodeficiency virus (HIV) mechanisms and provides valuable insights for the development of antiviral therapies. R-87366 serves as a key reagent for research focused on combating HIV infections. -
HIV-1 Protease Substrate
Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate specifically designed for assessing the activity of HIV-1 protease. This compound exhibits a strong interaction with the enzyme, facilitating the measurement of protease activity in research applications related to HIV-1 pathogenesis and antiviral drug development. Its utility in protease assays makes it a valuable tool for studying HIV-1 enzymatic function and evaluating potential therapeutic interventions. -
HIV Protease Inhibitor
Lopinavir Metabolite M-1 is a potent HIV protease inhibitor with a Ki of 0.7 pM. This active metabolite exhibits significant antiviral activity in vitro, making it valuable for research on HIV treatment and drug resistance mechanisms. Its efficacy in inhibiting HIV replication underlines its relevance in antiviral studies and therapeutic development. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-2 is a highly potent inhibitor of HIV-1 protease, exhibiting an IC50 of 2.53 nM. This compound demonstrates significant antiviral activity against both DRV-sensitive and DRV-resistant strains of HIV-1. It is a valuable tool for researching antiretroviral therapies and understanding HIV resistance mechanisms. -
HIV Protease
A76889 is an inhibitor of HIV-1 protease, crucial for viral replication and maturation. This compound effectively impedes the proteolytic activity of the enzyme, leading to the accumulation of non-infectious viral particles. A76889 is utilized in research focused on developing antiretroviral therapies and studying the mechanisms of HIV resistance. -
HIV-1 Protease Inhibitor
8-Prenylluteone is an HIV-1 protease inhibitor that demonstrates significant antiviral activity with an IC50 value of 4 μM. This compound is utilized in research focused on HIV-1 replication and its inhibition, making it a valuable tool for studying the effects of protease inhibition on viral pathogenesis and potential therapeutic strategies. -
HIV Protease Inhibitor
HIV protease-IN-1 is a potent non-peptidic inhibitor of HIV protease, designed to interfere with the viral life cycle. Its primary mechanism involves the inhibition of HIV protease, which is essential for the processing of viral polyproteins into functional proteins. This compound holds significant potential for research applications in the development of therapeutic strategies against AIDS and HIV-related pathologies. -
Renin/HIV-1 Protease Inhibitor
PD 134922 is a potent inhibitor of renin and HIV-1 protease, exhibiting an IC50 of 15 nM against HIV-1 protease. This compound is valuable in studies focused on the modulation of blood pressure regulation through renin inhibition and provides insights into HIV-1 protease activity. Its application extends to research in antiviral therapies and blood pressure-related disorders, making it a useful tool for scientists in pharmacological studies. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-12 is a potent inhibitor of HIV-1 protease, exhibiting an IC50 of 0.51 nM. This compound effectively targets both wild-type and drug-resistant variants of the enzyme, making it a valuable tool in HIV research. Its primary applications include the study of HIV-1 protease function and the development of antiviral therapies. -
HIV Protease
Elunonavir is a potent HIV protease inhibitor that exhibits a high barrier to resistance and remarkable metabolic stability. This compound effectively circumvents rapid CYP-mediated metabolism, leading to an extended half-life and the potential for reduced dosing frequency. Its unique properties make Elunonavir a valuable tool in HIV research and therapeutic development. -
HIV-1 PR/RT Inhibitor
HIV-1 inhibitor-53 is a dual inhibitor targeting HIV-1 protease (PR) and reverse transcriptase (RT). It demonstrates potent inhibitory activity with IC50 values of 1.93 nM for PR and 2.35 μM for RT, making it an important tool for studying HIV replication. This compound is suitable for research applications related to acquired immune deficiency syndrome (AIDS) and the development of antiretroviral therapies. -
Anti-HIV-1 Protease Drug
Ganoderic acid GS-1 is a highly oxygenated lanostane-type triterpenoid that exhibits significant anti-HIV-1 protease activity, with an IC50 value of 58 μM. This compound serves as a valuable tool in research aimed at elucidating the mechanisms of HIV-1 replication and protease function. Its potential role in therapeutic applications makes it a relevant candidate for further investigation in the development of antiviral strategies. -
HIV-1 Protease Substrato Peptídico
Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a peptide substrate specific for HIV-1 protease. This compound is utilized in peptidolytic assays to quantify the enzymatic inhibition of HIV-1 protease, providing valuable insights into protease activity and inhibitor efficacy. Its role as a variable substrate enhances the understanding of the protease's function, making it an essential tool in HIV research and drug development. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-8 is a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 0.32 nM. This compound effectively inhibits wild-type HIV-1 (HIV-1NL4-3) with an IC50 of 0.29 μM and a drug-resistant variant (HIV-1MDR) with an IC50 of 1.90 μM. Its strong antiviral activity against both strains makes HIV-1 protease-IN-8 a valuable tool for research in HIV treatment and drug resistance studies. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-5 is a potent inhibitor of HIV-1 protease, exhibiting an IC50 of 1.64 nM. This compound demonstrates significant efficacy against both wild-type and darunavir-resistant variants of HIV-1, making it a valuable tool for antiviral research. Its mechanism of action is crucial for developing therapeutic strategies to combat HIV-1 infections and resistance. -
HIV-1 Protease Inhibitor
Longipedunin A is a potent inhibitor of HIV-1 protease, exhibiting an IC50 value of 50 µg/mL. This compound effectively interferes with the proteolytic processing of viral polyproteins, thereby limiting HIV-1 replication. Longipedunin A is suitable for research applications in virology and studies focused on developing antiviral therapies. -
HIV-1 Inhibitor
U-75875 is an HIV-1 protease inhibitor that effectively impedes the processing of Gag-Pol proteins, thereby disrupting viral maturation and replication. This compound is primarily utilized in research focused on HIV-1 infection, providing valuable insights into viral life cycle mechanisms and potential therapeutic interventions. -
HIV-1 Protease Inhibitor
HIV-1 protease-IN-11 is a potent HIV-1 protease inhibitor with an IC50 value of 0.41 nM. This compound demonstrates significant efficacy against drug-resistant variants of the virus, offering opportunities for HIV research and therapeutic development. Its selective targeting of the HIV-1 protease positions it as a valuable tool in the study of HIV replication and infection mechanisms. -
HIV Protease
JG-365 is a potent inhibitor of HIV-1 protease that targets the enzyme's active site, effectively blocking its activity. This compound exhibits significant antiviral activity, making it a valuable tool for research in HIV infection and therapeutic development. Its ability to disrupt the replication cycle of HIV-1 provides insights into potential treatment strategies against HIV-related diseases. -
HIV Proteinase Inhibitor
AG-1284 is an effective HIV proteinase inhibitor, demonstrating an EC50 of 0.5 mg/mL. This compound is utilized in research focused on HIV infection mechanisms and therapeutic strategies aimed at viral suppression. AG-1284's inhibition of HIV proteinase makes it a valuable tool for studying the virus's replication cycle and potential drug development. -
HIV Protease Inhibitor
A-77003 is a potent HIV protease inhibitor, demonstrating an IC50 range of 0.1 to 0.2 μg/ml against both HIV-1 and HIV-2 proteases. This compound exhibits significant antiretroviral activity while maintaining low cytotoxicity in vitro, making it suitable for research applications focused on HIV treatment and therapeutic development. -
HIV-1 Protease Inhibitor
A 74704 is a pseudo C2-symmetric inhibitor targeting HIV-1 protease. This compound effectively disrupts the enzymatic activity of the protease, thereby inhibiting viral replication. It serves as a valuable reagent for studying HIV pathogenesis and developing antiviral therapies. -
HIV-1 Protease Inhibitor
A-80987 is a selective inhibitor of human immunodeficiency virus type 1 (HIV-1) protease. This compound effectively disrupts the proteolytic processing of viral polyproteins, thereby hindering viral replication. A-80987 is valuable for research focused on HIV pathogenesis and therapeutic interventions targeting viral enzyme activity. -
HIV-1 Reverse Transcriptase Inhibitor
Opaviraline is a potent HIV-1 reverse transcriptase inhibitor. It effectively disrupts the viral replication process by targeting the reverse transcriptase enzyme, which is crucial for converting viral RNA into DNA. This compound is utilized in research focused on developing antiviral therapies and understanding HIV-1 resistance mechanisms. -
HIV Protease Inhibitor
Ro 31-8588 is a potent HIV protease inhibitor, exhibiting a Ki of 0.3 nM. This compound is essential for studying the role of HIV protease in viral replication and can be utilized in research focused on AIDS treatment and potential therapeutic strategies. Its high affinity makes it a valuable tool for investigating the mechanistic aspects of HIV inhibition. -
HIV Protease Control
Hydroxy darunavir is a metabolite of the HIV-1 protease inhibitor darunavir, targeting the HIV protease to inhibit viral replication. It plays a significant role in understanding the pharmacokinetics and metabolism of darunavir and can be utilized in research applications aimed at studying HIV resistance mechanisms and therapeutic efficacy. This compound is essential for investigations into antiviral drug development and optimization strategies. -
HIV-1 Protease Inhibitor
LY-289612 is a potent HIV-1 protease inhibitor, exhibiting an IC50 value of 1.5 nM. This compound effectively disrupts the proteolytic processing of viral polyproteins, thereby inhibiting the replication of HIV-1. It is utilized in research focused on developing antiviral therapies and understanding HIV resistance mechanisms. -
HIV-1 Protease Inhibitor
PL-100 is a powerful inhibitor of HIV-1 protease, exhibiting a Ki of 36 pM and an EC50 of 16 nM. This compound effectively inhibits viral replication by targeting HIV-1 protease activity, showing significant antiviral efficacy against drug-resistant strains of the virus. PL-100 is suitable for research applications focused on understanding and combating drug-resistant HIV infections. -
Anti-Bacterial Agent
Pacidamycin 7 is an anti-bacterial agent primarily targeting Pseudomonas aeruginosa. This compound exhibits inhibitory effects on various bacterial strains, including suppurative Staphylococcus and Escherichia coli. Notably, serum and pH levels can modulate its antibacterial effectiveness, making it relevant for studies focused on resistance mechanisms and antibiotic development. -
Anti-Bacterial Agent
Kibdelin C1 is a potent anti-bacterial agent that exhibits activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It demonstrates similar efficacy to Vancomycin, making it a valuable compound for research aimed at combating resistant bacterial strains. Its unique mechanism offers potential applications in the development of new therapeutic strategies against resistant infections. -
Anti-Bacterial Agent
4"-Demethylgentamicin C1a acts as an anti-bacterial agent with significant efficacy against both Gram-positive and Gram-negative bacteria. Its mechanism involves inhibition of bacterial protein synthesis, making it a valuable tool in studies related to bacterial infections. This compound is relevant for research applications in microbiology and drug development, particularly for understanding antibiotic resistance and enhancing therapeutic strategies. -
Anti-Bacterial Agent
Oganomycin B is an antibacterial agent exhibiting pronounced stability compared to cephalosporin and demonstrating resistance to both Gram-positive and Gram-negative bacteria. Its efficacy is particularly notable in combating Gram-negative bacterial strains, making it a valuable tool for research into antibacterial treatments and mechanisms of resistance. -
Antibacterial Agent
KP 736 sodium is a broad-spectrum antibacterial agent that targets bacterial cell integrity. It demonstrates significant in vitro activity against Gram-negative bacteria, particularly Pseudomonas aeruginosa and other multidrug-resistant strains. This compound is valuable for research focused on bacterial infections and the development of novel antibacterial therapies. -
Anti-Bacterial Agent
Formadicin C is an anti-bacterial agent with notable effectiveness against various strains of Pseudomonas, Proteus, and alkali-producing bacilli. Its potent activity makes it a valuable compound for research focused on combating bacterial infections and understanding microbial resistance mechanisms. Researchers may utilize Formadicin C in studies pertaining to antibiotic efficacy and the development of new antimicrobial therapies. -
Anti-Bacterial Agent
Enaminomycin B is an anti-bacterial agent that exhibits activity against both Gram-positive and Gram-negative bacteria. This compound acts by disrupting bacterial cell wall synthesis, contributing to its potential as a therapeutic agent in combating bacterial infections. Enaminomycin B may be utilized in research applications focused on antibiotic resistance mechanisms and the development of new antibacterial strategies. -
Anti-Bacterial Agent
Kinamycin A is an antibacterial agent primarily targeting mycobacterial infections. It exhibits notable effects against various bacteria, while demonstrating limited efficacy against Gram-negative strains. This compound is valuable for research applications focused on the development of treatments for bacterial infections, particularly those caused by mycobacteria. -
Anti-Bacterial Agent
Quinomycin B is an anti-bacterial agent that exhibits potent activity against Gram-positive bacteria and is also effective against certain Gram-negative strains. Additionally, Quinomycin B demonstrates cytotoxic effects on HeLa cells, making it valuable in cancer research. This compound has also shown protective effects in mouse models inoculated with poliovirus, indicating potential applications in virology studies. -
Anti-Bacterial Agent
Kirrothricin is an antibacterial agent that primarily exhibits efficacy against a range of Gram-positive bacteria. It is particularly valuable in research focused on combating bacterial infections, providing insights into its use as a potential therapeutic candidate. However, it shows no activity against Bacillus subtilis, Escherichia coli, or fungal species. This specificity makes Kirrothricin a useful tool for studying antibacterial mechanisms and developing targeted treatments. -
Anti-Bacterial Agent
Cladospolide B is a natural compound derived from the fungal strain Cladosporium sp. FT-0012. It exhibits limited antibacterial activity, making it a potential candidate for further research into its mechanisms and applications in antimicrobial studies. This compound can be of interest for investigations focused on exploring novel antibacterial agents and their modes of action. -
Bacterial Inhibitor
2-C-Methyl-D-erythritol 4-phosphate is an intermediate in the methylerythritol phosphate (MEP) pathway, primarily present in prokaryotes. This compound plays a crucial role as a precursor in the biosynthesis of isoprenoids and non-isoprenoids, including essential vitamins. Its unique presence in bacteria, coupled with its absence in humans, positions it as a promising target for the development of bacterium-specific therapeutic agents for infectious disease treatment. -
Antibacterial Agent
Florfenicol-propanoate-piperidin serves as a potent antibacterial agent targeting various Gram-positive and Gram-negative bacteria. This compound demonstrates significant antibacterial activity, effectively inhibiting the growth of pathogens such as E. coli, Salmonella, S. aureus, B. subtilis, E. faecalis, S. suis, and Haemophilus parasuis, with minimum inhibitory concentrations (MIC) ranging from 2 to 8 μM. It is particularly useful in microbiological research focusing on bacterial resistance and infection control. -
Anti-Bacterial Agent
Ferensimycin B is a polyether antibiotic primarily targeting Gram-positive bacteria. It exhibits significant antibacterial activity while demonstrating weaker effects against Gram-negative bacteria, fungi, and coccidia. This compound is valuable for research applications involving the study of bacterial resistance mechanisms and the development of new antimicrobial agents. -
Anti-Bacterial Agent
Julimycin B2 is an anti-bacterial agent primarily targeting Gram-positive bacteria. This compound demonstrates significant activities against various bacterial strains and exhibits antiviral properties. Additionally, it has been shown to affect Ehrlich ascites carcinoma in murine models, making it a valuable reagent for studies in microbial infections and cancer research. -
Anti-Bacterial Agent
Chloropolysporin B is an anti-bacterial agent that exhibits potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus species. This compound is valuable for research focused on developing treatments for antibiotic-resistant infections and understanding bacterial resistance mechanisms. Its effectiveness against challenging strains makes it a crucial tool in the study of anti-bacterial therapies. -
Anti-Bacterial Agent
Cerexin B1 is an anti-bacterial agent that specifically targets Gram-positive bacteria. It exhibits potent activity against various strains, making it valuable for research in antibiotic efficacy and resistance mechanisms. This compound is suitable for studies focused on developing new antimicrobial therapies and understanding bacterial pathogenesis. -
Anti-Bacterial Agent
Saquayamycin B1 is an anti-bacterial agent primarily known for its antimicrobial properties. It exhibits significant activity against various bacterial strains, with a comparatively weaker effect on Gram-negative bacteria. Additionally, Saquayamycin B1 demonstrates inhibitory effects on leukemia P388 cells, including those resistant to Adriamycin, making it a potential candidate for cancer research and antimicrobial studies. -
Anti-Bacterial Agent
Pacidamycin 3 is an anti-bacterial agent that exhibits inhibitory activity against Pseudomonas aeruginosa and additional bacterial strains, including Staphylococcus aureus and Escherichia coli. This compound is utilized in research focused on understanding bacterial resistance mechanisms and developing new antimicrobial therapies. Its efficacy against a range of pathogenic bacteria makes it a valuable tool for microbiological studies and antibiotic development. -
Anti-Bacterial Agent
Megovalicin A is an anti-bacterial agent that demonstrates potent activity against Bacillus subtilis and Escherichia coli. It is primarily utilized in microbiological research to explore bacterial resistance mechanisms and to develop novel therapeutic strategies targeting bacterial infections. Its efficacy in inhibiting bacterial growth makes it a valuable tool for studies in infectious disease and antibiotic resistance. -
Antibacterial Agent
MBX-1066 is a potent antibacterial agent targeting Mycobacterium tuberculosis. This compound demonstrates significant antibacterial activity in preclinical models, including in vivo efficacy in mice. It is an important tool for research focused on tuberculosis treatment and drug discovery. -
Anti-Bacterial Agent
Curromycin B is an antibacterial agent primarily targeting Gram-positive bacteria, including Bacillus subtilis. It exhibits notable activity against human immunodeficiency virus (HIV) replication and displays cytotoxic effects on mouse melanoma B16 and leukemia P388 cells. This compound is valuable for research applications in microbiology and oncology, offering insights into antibacterial mechanisms and potential therapeutic strategies.
