CAP 3 is a cholic acid-peptide conjugate that acts as an effective antibacterial agent targeting Gram-negative bacteria. It demonstrates potent antibacterial activity with minimum inhibitory concentration (MIC99) values of 8 μM, 16 μM, and 16 μM against E. coli, Klebsiella pneumoniae, and Acinetobacter baumannii, respectively. CAP 3 functions by disrupting the structural integrity of bacterial lipopolysaccharide (LPS) outer membranes, leading to rapid bacterial cell death. Additionally, it inhibits biofilm formation and shows efficacy against drug-resistant strains, making it valuable for addressing persistent bacterial infections in research settings.
CAP 3 is a cholic acid-peptide conjugate that acts as an effective antibacterial agent targeting Gram-negative bacteria. It demonstrates potent antibacterial activity with minimum inhibitory concentration (MIC99) values of 8 μM, 16 μM, and 16 μM against E. coli, Klebsiella pneumoniae, and Acinetobacter baumannii, respectively. CAP 3 functions by disrupting the structural integrity of bacterial lipopolysaccharide (LPS) outer membranes, leading to rapid bacterial cell death. Additionally, it inhibits biofilm formation and shows efficacy against drug-resistant strains, making it valuable for addressing persistent bacterial infections in research settings.
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